Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13

• Published in: Critical care medicine Vol. 40; no. 9; p. 2647
• Main Authors: Wohlauer, Max, Moore, Ernest E, Silliman, Christopher C, Fragoso, Miguel, Gamboni, Fabia, Harr, Jeffrey, Accurso, Frank, Wright, Frank, Haenel, James, Fullerton, David, Banerjee, Anirban
• Format: Journal Article
• Language: English
• Published: United States 01.09.2012
• Subjects: Acute Lung Injury - drug therapy; Acute Lung Injury - etiology; Acute Lung Injury - pathology; Administration, Inhalation; Animals; Biopsy, Needle; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Immunohistochemistry; Male; Matrix Metalloproteinase 13 - drug effects; Matrix Metalloproteinase 13 - metabolism; Nebulizers and Vaporizers; Neutrophil Infiltration - physiology; Random Allocation; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome, Adult - drug therapy; Respiratory Distress Syndrome, Adult - etiology; Respiratory Distress Syndrome, Adult - pathology; Saline Solution, Hypertonic - pharmacology; Sensitivity and Specificity; Shock, Hemorrhagic - complications; Wounds and Injuries - complications

We hypothesized that aerosolized inhaled hypertonic saline given at the onset of resuscitation will decrease acute lung injury following hemorrhagic shock, by inhibiting the release of epithelial derived proinflammatory mediators. Animal study. Animal-care facility procedure room in a medical center...