Diffusion imaging of nigral alterations in early Parkinson's disease with dopaminergic deficits
ABSTRACT Background This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects from the Parkinson's Progression Markers Initiative. The main goals were to replicate previous findings of abnormal diffusi...
Saved in:
| Published in | Movement disorders Vol. 30; no. 14; pp. 1885 - 1892 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Blackwell Publishing Ltd
01.12.2015
Wiley Subscription Services, Inc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0885-3185 1531-8257 1531-8257 |
| DOI | 10.1002/mds.26325 |
Cover
| Abstract | ABSTRACT
Background
This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects from the Parkinson's Progression Markers Initiative. The main goals were to replicate previous findings of abnormal diffusion imaging values from the substantia nigra. in a large multicenter cohort and determine whether nigral diffusion alterations are associated with dopamine deficits.
Methods
Two hundred twenty subjects (PD = 153; control = 67) from 10 imaging sites were included. All subjects had a full neurological exam, a (123I)ioflupane dopamine transporter (DAT) single‐photon emission computer tomography scan, and diffusion tensor imaging. Fractional anisotropy as well as radial and axial diffusivity was computed within multiple regions across the substantia nigra.
Results
A repeated‐measures analysis of variance found a marginally nonsignificant interaction between regional fractional anisotropy of the substantia nigra and disease status (P = 0.08), conflicting with an earlier study. However, a linear mixed model that included control regions in addition to the nigral regions revealed a significant interaction between regions and disease status (P = 0.002), implying a characteristic distribution of reduced fractional anisotropy across the substantia nigra in PD. Reduced fractional anisotropy in PD was also associated with diminished DAT binding ratios. Both axial and radial diffusivity were also abnormal in PD.
Conclusions
Although routine nigral measurements of fractional anisotropy are clinically not helpful, the findings in this study suggest that more‐sophisticated diffusion imaging protocols should be used when exploring the clinical utility of this imaging modality. © 2015 International Parkinson and Movement Disorder Society |
|---|---|
| AbstractList | This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects from the Parkinson's Progression Markers Initiative. The main goals were to replicate previous findings of abnormal diffusion imaging values from the substantia nigra. in a large multicenter cohort and determine whether nigral diffusion alterations are associated with dopamine deficits.BACKGROUNDThis study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects from the Parkinson's Progression Markers Initiative. The main goals were to replicate previous findings of abnormal diffusion imaging values from the substantia nigra. in a large multicenter cohort and determine whether nigral diffusion alterations are associated with dopamine deficits.Two hundred twenty subjects (PD = 153; control = 67) from 10 imaging sites were included. All subjects had a full neurological exam, a ((123) I)ioflupane dopamine transporter (DAT) single-photon emission computer tomography scan, and diffusion tensor imaging. Fractional anisotropy as well as radial and axial diffusivity was computed within multiple regions across the substantia nigra.METHODSTwo hundred twenty subjects (PD = 153; control = 67) from 10 imaging sites were included. All subjects had a full neurological exam, a ((123) I)ioflupane dopamine transporter (DAT) single-photon emission computer tomography scan, and diffusion tensor imaging. Fractional anisotropy as well as radial and axial diffusivity was computed within multiple regions across the substantia nigra.A repeated-measures analysis of variance found a marginally nonsignificant interaction between regional fractional anisotropy of the substantia nigra and disease status (P = 0.08), conflicting with an earlier study. However, a linear mixed model that included control regions in addition to the nigral regions revealed a significant interaction between regions and disease status (P = 0.002), implying a characteristic distribution of reduced fractional anisotropy across the substantia nigra in PD. Reduced fractional anisotropy in PD was also associated with diminished DAT binding ratios. Both axial and radial diffusivity were also abnormal in PD.RESULTSA repeated-measures analysis of variance found a marginally nonsignificant interaction between regional fractional anisotropy of the substantia nigra and disease status (P = 0.08), conflicting with an earlier study. However, a linear mixed model that included control regions in addition to the nigral regions revealed a significant interaction between regions and disease status (P = 0.002), implying a characteristic distribution of reduced fractional anisotropy across the substantia nigra in PD. Reduced fractional anisotropy in PD was also associated with diminished DAT binding ratios. Both axial and radial diffusivity were also abnormal in PD.Although routine nigral measurements of fractional anisotropy are clinically not helpful, the findings in this study suggest that more-sophisticated diffusion imaging protocols should be used when exploring the clinical utility of this imaging modality.CONCLUSIONSAlthough routine nigral measurements of fractional anisotropy are clinically not helpful, the findings in this study suggest that more-sophisticated diffusion imaging protocols should be used when exploring the clinical utility of this imaging modality. This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects from the Parkinson's Progression Markers Initiative. The main goals were to replicate previous findings of abnormal diffusion imaging values from the substantia nigra. in a large multicenter cohort and determine whether nigral diffusion alterations are associated with dopamine deficits. Two hundred twenty subjects (PD = 153; control = 67) from 10 imaging sites were included. All subjects had a full neurological exam, a ((123) I)ioflupane dopamine transporter (DAT) single-photon emission computer tomography scan, and diffusion tensor imaging. Fractional anisotropy as well as radial and axial diffusivity was computed within multiple regions across the substantia nigra. A repeated-measures analysis of variance found a marginally nonsignificant interaction between regional fractional anisotropy of the substantia nigra and disease status (P = 0.08), conflicting with an earlier study. However, a linear mixed model that included control regions in addition to the nigral regions revealed a significant interaction between regions and disease status (P = 0.002), implying a characteristic distribution of reduced fractional anisotropy across the substantia nigra in PD. Reduced fractional anisotropy in PD was also associated with diminished DAT binding ratios. Both axial and radial diffusivity were also abnormal in PD. Although routine nigral measurements of fractional anisotropy are clinically not helpful, the findings in this study suggest that more-sophisticated diffusion imaging protocols should be used when exploring the clinical utility of this imaging modality. Background This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects from the Parkinson's Progression Markers Initiative. The main goals were to replicate previous findings of abnormal diffusion imaging values from the substantia nigra. in a large multicenter cohort and determine whether nigral diffusion alterations are associated with dopamine deficits. Methods Two hundred twenty subjects (PD=153; control=67) from 10 imaging sites were included. All subjects had a full neurological exam, a ( super(123)I)ioflupane dopamine transporter (DAT) single-photon emission computer tomography scan, and diffusion tensor imaging. Fractional anisotropy as well as radial and axial diffusivity was computed within multiple regions across the substantia nigra. Results A repeated-measures analysis of variance found a marginally nonsignificant interaction between regional fractional anisotropy of the substantia nigra and disease status (P=0.08), conflicting with an earlier study. However, a linear mixed model that included control regions in addition to the nigral regions revealed a significant interaction between regions and disease status (P=0.002), implying a characteristic distribution of reduced fractional anisotropy across the substantia nigra in PD. Reduced fractional anisotropy in PD was also associated with diminished DAT binding ratios. Both axial and radial diffusivity were also abnormal in PD. Conclusions Although routine nigral measurements of fractional anisotropy are clinically not helpful, the findings in this study suggest that more-sophisticated diffusion imaging protocols should be used when exploring the clinical utility of this imaging modality. copyright 2015 International Parkinson and Movement Disorder Society Background This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects from the Parkinson's Progression Markers Initiative. The main goals were to replicate previous findings of abnormal diffusion imaging values from the substantia nigra. in a large multicenter cohort and determine whether nigral diffusion alterations are associated with dopamine deficits. Methods Two hundred twenty subjects (PD=153; control=67) from 10 imaging sites were included. All subjects had a full neurological exam, a (123I)ioflupane dopamine transporter (DAT) single-photon emission computer tomography scan, and diffusion tensor imaging. Fractional anisotropy as well as radial and axial diffusivity was computed within multiple regions across the substantia nigra. Results A repeated-measures analysis of variance found a marginally nonsignificant interaction between regional fractional anisotropy of the substantia nigra and disease status (P=0.08), conflicting with an earlier study. However, a linear mixed model that included control regions in addition to the nigral regions revealed a significant interaction between regions and disease status (P=0.002), implying a characteristic distribution of reduced fractional anisotropy across the substantia nigra in PD. Reduced fractional anisotropy in PD was also associated with diminished DAT binding ratios. Both axial and radial diffusivity were also abnormal in PD. Conclusions Although routine nigral measurements of fractional anisotropy are clinically not helpful, the findings in this study suggest that more-sophisticated diffusion imaging protocols should be used when exploring the clinical utility of this imaging modality. © 2015 International Parkinson and Movement Disorder Society ABSTRACT Background This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects from the Parkinson's Progression Markers Initiative. The main goals were to replicate previous findings of abnormal diffusion imaging values from the substantia nigra. in a large multicenter cohort and determine whether nigral diffusion alterations are associated with dopamine deficits. Methods Two hundred twenty subjects (PD = 153; control = 67) from 10 imaging sites were included. All subjects had a full neurological exam, a (123I)ioflupane dopamine transporter (DAT) single‐photon emission computer tomography scan, and diffusion tensor imaging. Fractional anisotropy as well as radial and axial diffusivity was computed within multiple regions across the substantia nigra. Results A repeated‐measures analysis of variance found a marginally nonsignificant interaction between regional fractional anisotropy of the substantia nigra and disease status (P = 0.08), conflicting with an earlier study. However, a linear mixed model that included control regions in addition to the nigral regions revealed a significant interaction between regions and disease status (P = 0.002), implying a characteristic distribution of reduced fractional anisotropy across the substantia nigra in PD. Reduced fractional anisotropy in PD was also associated with diminished DAT binding ratios. Both axial and radial diffusivity were also abnormal in PD. Conclusions Although routine nigral measurements of fractional anisotropy are clinically not helpful, the findings in this study suggest that more‐sophisticated diffusion imaging protocols should be used when exploring the clinical utility of this imaging modality. © 2015 International Parkinson and Movement Disorder Society |
| Author | Jankovic, Joseph Schuff, Norbert Zhang, Yu Sprenger, Fabienne Seibyl, John Seppi, Klaus Mari, Zoltan Coffey, Christopher S. Knake, Susanne Tanner, Caroline M. Simuni, Tanya Factor, Stewart Mollenhauer, Brit Mendick, Susan Marek, Kenneth Ranola, Madelaine Foster, Eric D. Berg, Daniela Gitelman, Darren R. Gauss, Katharina Buckley, Shannon Hunter, Christine Poewe, Werner McCoy, Arita Rees, Linda Wu, I-Wei Wurster, Isabel |
| Author_xml | – sequence: 1 givenname: Norbert surname: Schuff fullname: Schuff, Norbert email: norbert.schuff@ucsf.edu organization: Department of Veteran Affairs Medical Center, San Francisco, California, USA – sequence: 2 givenname: I-Wei surname: Wu fullname: Wu, I-Wei organization: Department of Veteran Affairs Medical Center, San Francisco, California, USA – sequence: 3 givenname: Shannon surname: Buckley fullname: Buckley, Shannon organization: Department of Veteran Affairs Medical Center, San Francisco, California, USA – sequence: 4 givenname: Eric D. surname: Foster fullname: Foster, Eric D. organization: Department of Biostatistics, College of Public Health, University of Iowa, Iowa, Iowa City, USA – sequence: 5 givenname: Christopher S. surname: Coffey fullname: Coffey, Christopher S. organization: Department of Biostatistics, College of Public Health, University of Iowa, Iowa, Iowa City, USA – sequence: 6 givenname: Darren R. surname: Gitelman fullname: Gitelman, Darren R. organization: Department of Neurology, Feinberg School of Medicine, Northwestern University, Illinois, Chicago, USA – sequence: 7 givenname: Susan surname: Mendick fullname: Mendick, Susan organization: Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), Connecticut, New Haven, USA – sequence: 8 givenname: John surname: Seibyl fullname: Seibyl, John organization: Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), Connecticut, New Haven, USA – sequence: 9 givenname: Tanya surname: Simuni fullname: Simuni, Tanya organization: Department of Neurology, Feinberg School of Medicine, Northwestern University, Illinois, Chicago, USA – sequence: 10 givenname: Yu surname: Zhang fullname: Zhang, Yu organization: Department of Veteran Affairs Medical Center, San Francisco, California, USA – sequence: 11 givenname: Joseph surname: Jankovic fullname: Jankovic, Joseph organization: Baylor College of Medicine, Texas, Houston, USA – sequence: 12 givenname: Christine surname: Hunter fullname: Hunter, Christine organization: Baylor College of Medicine, Texas, Houston, USA – sequence: 13 givenname: Caroline M. surname: Tanner fullname: Tanner, Caroline M. organization: Department of Veteran Affairs Medical Center, San Francisco, California, USA – sequence: 14 givenname: Linda surname: Rees fullname: Rees, Linda organization: Department of Neurology, University of California, CA, San Francisco, USA – sequence: 15 givenname: Stewart surname: Factor fullname: Factor, Stewart organization: Emory University, Georgia, Atlanta, USA – sequence: 16 givenname: Daniela surname: Berg fullname: Berg, Daniela organization: University of Tuebingen, Tuebingen, Germany – sequence: 17 givenname: Isabel surname: Wurster fullname: Wurster, Isabel organization: University of Tuebingen, Tuebingen, Germany – sequence: 18 givenname: Katharina surname: Gauss fullname: Gauss, Katharina organization: University of Tuebingen, Tuebingen, Germany – sequence: 19 givenname: Fabienne surname: Sprenger fullname: Sprenger, Fabienne organization: Innsbruck Medical University, Innsbruck, Austria – sequence: 20 givenname: Klaus surname: Seppi fullname: Seppi, Klaus organization: Innsbruck Medical University, Innsbruck, Austria – sequence: 21 givenname: Werner surname: Poewe fullname: Poewe, Werner organization: Innsbruck Medical University, Innsbruck, Austria – sequence: 22 givenname: Brit surname: Mollenhauer fullname: Mollenhauer, Brit organization: Paracelsus-Elena Klinik, Kassel, Germany – sequence: 23 givenname: Susanne surname: Knake fullname: Knake, Susanne organization: Paracelsus-Elena Klinik, Kassel, Germany – sequence: 24 givenname: Zoltan surname: Mari fullname: Mari, Zoltan organization: Johns Hopkins University, Maryland, Baltimore, USA – sequence: 25 givenname: Arita surname: McCoy fullname: McCoy, Arita organization: Johns Hopkins University, Maryland, Baltimore, USA – sequence: 26 givenname: Madelaine surname: Ranola fullname: Ranola, Madelaine organization: Macquarie University, Sydney, Australia – sequence: 27 givenname: Kenneth surname: Marek fullname: Marek, Kenneth organization: Institute for Neurodegenerative Disorders (IND) and Molecular Neuroimaging, LLC (MNI), Connecticut, New Haven, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26260437$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkc1u1DAYRS1URKeFBS-ALLEAFmn9E9vJsurQGaTyIwFC6sZynM-DS-IMdqIyb4-nM8OiAomVF985V_K9J-goDAEQek7JGSWEnfdtOmOSM_EIzajgtKiYUEdoRqpKFJxW4hidpHRLCKWCyifomEkmScnVDOm5d25KfgjY92blwwoPDge_iqbDphshmjEfE_YBg4ndBn8y8YcPaQivEm59ApMA3_nxO26Htel9gLjyFrfgvPVjeooeO9MleLZ_T9HXq7dfLpfF9cfFu8uL68KWdSmKkllHJQVuS2DMtYxY6iyxpQIioWbONA2vGyWEaKUjvCVUiFqBbYhjStT8FL3e5a7j8HOCNOreJwtdZwIMU9JUVURQJavyP1BJqloJtU19-QC9HaYY8kcyJbZIJVSmXuypqemh1euYq4wbfWg5A-c7wMYhpQhO52ruex2j8Z2mRG931HlHfb9jNt48MA6hf2P36Xe-g82_Qf1-_vlgFDvDpxF-_THysFoqroT-9mGhl8ub-eKGX-kl_w2BXLrH |
| CODEN | MOVDEA |
| CitedBy_id | crossref_primary_10_1016_j_artmed_2022_102251 crossref_primary_10_1016_j_bbi_2016_11_027 crossref_primary_10_3389_fnsys_2021_777706 crossref_primary_10_1371_journal_pone_0163774 crossref_primary_10_1007_s00415_022_11259_9 crossref_primary_10_1038_srep35601 crossref_primary_10_1371_journal_pone_0217922 crossref_primary_10_1038_s42003_021_02705_x crossref_primary_10_1186_s40478_017_0439_3 crossref_primary_10_1186_s43055_024_01340_w crossref_primary_10_1016_j_nicl_2023_103315 crossref_primary_10_1016_j_parkreldis_2020_08_010 crossref_primary_10_1016_j_parkreldis_2019_01_007 crossref_primary_10_3233_JPD_161011 crossref_primary_10_7717_peerj_1381 crossref_primary_10_1148_radiol_2019181042 crossref_primary_10_1002_mds_27100 crossref_primary_10_1038_s41531_024_00854_4 crossref_primary_10_1097_WCO_0000000000000521 crossref_primary_10_1212_WNL_0000000000006646 crossref_primary_10_1371_journal_pone_0165540 crossref_primary_10_1016_j_trsl_2015_12_006 crossref_primary_10_1093_braincomms_fcab251 crossref_primary_10_3389_fnagi_2019_00134 crossref_primary_10_1002_hbm_24878 crossref_primary_10_1002_mds_27201 crossref_primary_10_1002_acn3_644 crossref_primary_10_2967_jnumed_120_248500 crossref_primary_10_1016_j_jns_2021_120032 crossref_primary_10_3389_fnana_2016_00017 crossref_primary_10_1007_s00702_017_1717_8 crossref_primary_10_1371_journal_pone_0175674 crossref_primary_10_3389_fnagi_2020_563595 crossref_primary_10_3389_fneur_2020_531993 crossref_primary_10_1093_brain_awv361 crossref_primary_10_1371_journal_pone_0282684 crossref_primary_10_3174_ajnr_A5545 crossref_primary_10_1007_s00330_016_4611_0 crossref_primary_10_1007_s00415_024_12773_8 crossref_primary_10_3389_fneur_2020_00314 crossref_primary_10_1002_hbm_26009 crossref_primary_10_1038_srep38070 crossref_primary_10_1007_s00701_024_06096_w crossref_primary_10_1016_j_clineuro_2025_108817 |
| Cites_doi | 10.1016/j.parkreldis.2012.05.021 10.1136/jnnp.2007.121525 10.1016/j.pneurobio.2011.09.005 10.1016/j.ejrad.2009.07.032 10.1212/WNL.0b013e318284070c 10.1002/mds.22340 10.1016/j.nicl.2013.10.006 10.1002/mrm.20642 10.1109/TAC.1974.1100705 10.1212/01.wnl.0000340982.01727.6e 10.1002/nbm.782 10.1136/jnnp.2006.110122 10.1016/S0896-6273(03)00758-X 10.1212/WNL.17.5.427 10.1212/WNL.43.4.829 10.1016/j.neuroimage.2009.05.017 10.1148/radiol.14131448 10.1148/radiology.201.3.8939209 10.1002/hbm.22217 10.1016/j.nbd.2007.02.010 10.1097/00005072-199111000-00006 10.1002/mds.25182 10.1002/mds.25383 |
| ContentType | Journal Article |
| Copyright | 2015 International Parkinson and Movement Disorder Society 2015 International Parkinson and Movement Disorder Society. |
| Copyright_xml | – notice: 2015 International Parkinson and Movement Disorder Society – notice: 2015 International Parkinson and Movement Disorder Society. |
| DBID | BSCLL AAYXX CITATION CGR CUY CVF ECM EIF NPM 7TK 8FD FR3 K9. NAPCQ P64 RC3 7X8 |
| DOI | 10.1002/mds.26325 |
| DatabaseName | Istex CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Neurosciences Abstracts Technology Research Database Engineering Research Database ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Nursing & Allied Health Premium Genetics Abstracts Technology Research Database ProQuest Health & Medical Complete (Alumni) Engineering Research Database Neurosciences Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Neurosciences Abstracts Nursing & Allied Health Premium |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1531-8257 |
| EndPage | 1892 |
| ExternalDocumentID | 3923659681 26260437 10_1002_mds_26325 MDS26325 ark_67375_WNG_HHZDGZ3F_H |
| Genre | article Journal Article |
| GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 123 1CY 1L6 1OB 1OC 1ZS 31~ 33P 3PY 3SF 3WU 4.4 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5VS 66C 6PF 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHQN AAIPD AAMMB AAMNL AANHP AANLZ AAONW AASGY AAWTL AAXRX AAYCA AAZKR ABCQN ABCUV ABEML ABIJN ABJNI ABLJU ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN AEFGJ AEIGN AEIMD AENEX AEUYR AEYWJ AFBPY AFFPM AFGKR AFWVQ AFZJQ AGHNM AGQPQ AGXDD AGYGG AHBTC AHMBA AIACR AIDQK AIDYY AITYG AIURR ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BSCLL BY8 C45 CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR1 DR2 DRFUL DRMAN DRSTM DU5 EBD EBS EJD EMOBN F00 F01 F04 F5P FEDTE FUBAC FYBCS G-S G.N GNP GODZA H.X HBH HF~ HGLYW HHY HHZ HVGLF HZ~ IX1 J0M JPC KBYEO KQQ LATKE LAW LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M6M MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NNB O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K RIWAO RJQFR ROL RX1 RYL SAMSI SUPJJ SV3 TEORI TWZ UB1 V2E V9Y W8V W99 WBKPD WHWMO WIB WIH WIJ WIK WJL WOHZO WQJ WVDHM WXI WXSBR XG1 XV2 ZGI ZZTAW ~IA ~WT AAHHS AAYXX ACCFJ AEEZP AEQDE AIWBW AJBDE CITATION CGR CUY CVF ECM EIF NPM YCJ 7TK 8FD FR3 K9. NAPCQ P64 RC3 7X8 |
| ID | FETCH-LOGICAL-c4945-42cf161e3c4e22fd20c1fc0c47e06e92fabb39b7555d6f03d015597ecb0f27593 |
| IEDL.DBID | DR2 |
| ISSN | 0885-3185 1531-8257 |
| IngestDate | Thu Jul 10 19:56:24 EDT 2025 Fri Jul 11 05:12:09 EDT 2025 Fri Jul 25 09:56:33 EDT 2025 Thu Apr 03 07:07:02 EDT 2025 Tue Jul 01 01:44:19 EDT 2025 Thu Apr 24 22:54:48 EDT 2025 Wed Aug 20 07:24:40 EDT 2025 Tue Sep 09 05:29:46 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 14 |
| Keywords | fractional anisotropy substantia nigra dopamine neuroimaging |
| Language | English |
| License | http://onlinelibrary.wiley.com/termsAndConditions#vor 2015 International Parkinson and Movement Disorder Society. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4945-42cf161e3c4e22fd20c1fc0c47e06e92fabb39b7555d6f03d015597ecb0f27593 |
| Notes | istex:9A8502569709B75BB35DEA1E92D1E182CF17CDD3 ark:/67375/WNG-HHZDGZ3F-H ArticleID:MDS26325 Relevant conflicts of interest/financial disclosures Full financial disclosures and author roles may be found in the online version of this article. Nothing to report. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 26260437 |
| PQID | 1757579857 |
| PQPubID | 1016421 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1780517684 proquest_miscellaneous_1760897579 proquest_journals_1757579857 pubmed_primary_26260437 crossref_citationtrail_10_1002_mds_26325 crossref_primary_10_1002_mds_26325 wiley_primary_10_1002_mds_26325_MDS26325 istex_primary_ark_67375_WNG_HHZDGZ3F_H |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | December 2015 |
| PublicationDateYYYYMMDD | 2015-12-01 |
| PublicationDate_xml | – month: 12 year: 2015 text: December 2015 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Hoboken |
| PublicationTitle | Movement disorders |
| PublicationTitleAlternate | Mov Disord |
| PublicationYear | 2015 |
| Publisher | Blackwell Publishing Ltd Wiley Subscription Services, Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Wiley Subscription Services, Inc |
| References | Menke RA, Scholz J, Miller KL, et al. MRI characteristics of the substantia nigra in Parkinson's disease: a combined quantitative T1 and DTI study. Neuroimage 2009;47:435-441. Tuch DS, Reese TG, Wiegell MR, Wedeen VJ. Diffusion MRI of complex neural architecture. Neuron 2003;40:885-895. Schwarz ST, Abaei M, Gontu V, Morgan PS, Bajaj N, Auer DP. Diffusion tensor imaging of nigral degeneration in Parkinson's disease: a region-of-interest and voxel-based study at 3 T and systematic review with meta-analysis. Neuroimage Clin 2013;3:481-488. Akaike H. A new look at the statistical model identification. IEEE Trans Automat Contr 1974;19:716-723. Wedeen VJ, Hagmann P, Tseng WY, Reese TG, Weisskoff RM. Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging. Magn Reson Med 2005;54:1377-1386. Stebbins GT, Goetz CG, Burn DJ, Jankovic J, Khoo TK, Tilley BC. How to identify tremor dominant and postural instability/gait difficulty groups with the Movement Disorder Society Unified Parkinson's Disease Rating Scale: comparison with the Unified Parkinson's Disease Rating Scale. Mov Disord 2013;28:668-670. Vaillancourt DE, Spraker MB, Prodoehl J, et al. High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease. Neurology 2009;72:1378-1384. Cosottini M, Frosini D, Pesaresi I, et al. MR imaging of the substantia nigra at 7 T enables diagnosis of Parkinson disease. Radiology 2014;271:831-838. Zhang K, Yu C, Zhang Y, et al. Voxel-based analysis of diffusion tensor indices in the brain in patients with Parkinson's disease. Eur J Radiol 2011;77:269-273. Goetz CG, Tilley BC, Shaftman SR, et al. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord 2008;23:2129-2170. Naylor MG, Cardenas VA, Tosun D, Schuff N, Weiner M, Schwartzman A. Voxelwise multivariate analysis of multimodality magnetic resonance imaging. Hum Brain Mapp 2014;35:831-846. Boska MD, Hasan KM, Kibuule D, et al. Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease. Neurobiol Dis 2007;26:590-596. Marek K. The Parkinson Progression Marker Initiative (PPMI). Prog Neurobiol 2011;95:629-635. Chan LL, Rumpel H, Yap K, et al. Case control study of diffusion tensor imaging in Parkinson's disease. J Neurol Neurosurg Psychiatry 2007;78:1383-1386. Paulus W, Jellinger K. The neuropathologic basis of different clinical subgroups of Parkinson's disease. J Neuropathol Exp Neurol 1991;50:743-755. Beaulieu C. The basis of anisotropic water diffusion in the nervous system-a technical review. NMR Biomed 2002;15:435-455. Walker Z, Jaros E, Walker RW, et al. Dementia with Lewy bodies: a comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy. J Neurol Neurosurg Psychiatry 2007;78:1176-1181. Simuni T, Caspell-Garcia C, Coffey C, et al. Can we reliably establish Parkinson disease subtypes in de novo patients: follow-up results from the PPMI study [abstract]. 18th International Congress of Parkinson's Disease and Movement Disorders; 2014;29(Suppl 1):1064. Pierpaoli C, Jezzard P, Basser PJ, Barnett A, Di Chiro G. Diffusion tensor MR imaging of the human brain. Radiology 1996;201:637-648. Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967;17:427-442. Rajput AH, Pahwa R, Pahwa P, Rajput A. Prognostic significance of the onset mode in parkinsonism. Neurology 1993;43:829-830. Cochrane CJ, Ebmeier KP. Diffusion tensor imaging in parkinsonian syndromes: a systematic review and meta-analysis. Neurology 2013;80:857-864. Prakash BD, Sitoh YY, Tan LC, Au WL. Asymmetrical diffusion tensor imaging indices of the rostral substantia nigra in Parkinson's disease. Parkinsonism Relat Disord 2012;18:1029-1033. Du G, Lewis MM, Sen S, et al. Imaging nigral pathology and clinical progression in Parkinson's disease. Mov Disord 2012;27:1636-1643. 2009; 47 2002; 15 2013; 3 2013; 28 2009; 72 1993; 43 2011; 95 1991; 50 2013; 80 1967; 17 2008; 23 2011; 77 2014; 35 2005; 54 2012; 18 2014; 271 2012; 27 2014; 29 1996; 201 2003; 40 2007; 78 1974; 19 2007; 26 e_1_2_8_17_1 e_1_2_8_18_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_24_1 e_1_2_8_14_1 e_1_2_8_25_1 e_1_2_8_15_1 e_1_2_8_16_1 Simuni T (e_1_2_8_23_1) 2014; 29 e_1_2_8_3_1 e_1_2_8_2_1 e_1_2_8_5_1 e_1_2_8_4_1 e_1_2_8_7_1 e_1_2_8_6_1 e_1_2_8_9_1 e_1_2_8_8_1 e_1_2_8_20_1 e_1_2_8_10_1 e_1_2_8_21_1 e_1_2_8_11_1 e_1_2_8_22_1 e_1_2_8_12_1 |
| References_xml | – reference: Akaike H. A new look at the statistical model identification. IEEE Trans Automat Contr 1974;19:716-723. – reference: Du G, Lewis MM, Sen S, et al. Imaging nigral pathology and clinical progression in Parkinson's disease. Mov Disord 2012;27:1636-1643. – reference: Cochrane CJ, Ebmeier KP. Diffusion tensor imaging in parkinsonian syndromes: a systematic review and meta-analysis. Neurology 2013;80:857-864. – reference: Menke RA, Scholz J, Miller KL, et al. MRI characteristics of the substantia nigra in Parkinson's disease: a combined quantitative T1 and DTI study. Neuroimage 2009;47:435-441. – reference: Stebbins GT, Goetz CG, Burn DJ, Jankovic J, Khoo TK, Tilley BC. How to identify tremor dominant and postural instability/gait difficulty groups with the Movement Disorder Society Unified Parkinson's Disease Rating Scale: comparison with the Unified Parkinson's Disease Rating Scale. Mov Disord 2013;28:668-670. – reference: Prakash BD, Sitoh YY, Tan LC, Au WL. Asymmetrical diffusion tensor imaging indices of the rostral substantia nigra in Parkinson's disease. Parkinsonism Relat Disord 2012;18:1029-1033. – reference: Simuni T, Caspell-Garcia C, Coffey C, et al. Can we reliably establish Parkinson disease subtypes in de novo patients: follow-up results from the PPMI study [abstract]. 18th International Congress of Parkinson's Disease and Movement Disorders; 2014;29(Suppl 1):1064. – reference: Marek K. The Parkinson Progression Marker Initiative (PPMI). Prog Neurobiol 2011;95:629-635. – reference: Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967;17:427-442. – reference: Cosottini M, Frosini D, Pesaresi I, et al. MR imaging of the substantia nigra at 7 T enables diagnosis of Parkinson disease. Radiology 2014;271:831-838. – reference: Pierpaoli C, Jezzard P, Basser PJ, Barnett A, Di Chiro G. Diffusion tensor MR imaging of the human brain. Radiology 1996;201:637-648. – reference: Naylor MG, Cardenas VA, Tosun D, Schuff N, Weiner M, Schwartzman A. Voxelwise multivariate analysis of multimodality magnetic resonance imaging. Hum Brain Mapp 2014;35:831-846. – reference: Vaillancourt DE, Spraker MB, Prodoehl J, et al. High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease. Neurology 2009;72:1378-1384. – reference: Goetz CG, Tilley BC, Shaftman SR, et al. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord 2008;23:2129-2170. – reference: Rajput AH, Pahwa R, Pahwa P, Rajput A. Prognostic significance of the onset mode in parkinsonism. Neurology 1993;43:829-830. – reference: Tuch DS, Reese TG, Wiegell MR, Wedeen VJ. Diffusion MRI of complex neural architecture. Neuron 2003;40:885-895. – reference: Schwarz ST, Abaei M, Gontu V, Morgan PS, Bajaj N, Auer DP. Diffusion tensor imaging of nigral degeneration in Parkinson's disease: a region-of-interest and voxel-based study at 3 T and systematic review with meta-analysis. Neuroimage Clin 2013;3:481-488. – reference: Walker Z, Jaros E, Walker RW, et al. Dementia with Lewy bodies: a comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy. J Neurol Neurosurg Psychiatry 2007;78:1176-1181. – reference: Boska MD, Hasan KM, Kibuule D, et al. Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease. Neurobiol Dis 2007;26:590-596. – reference: Zhang K, Yu C, Zhang Y, et al. Voxel-based analysis of diffusion tensor indices in the brain in patients with Parkinson's disease. Eur J Radiol 2011;77:269-273. – reference: Wedeen VJ, Hagmann P, Tseng WY, Reese TG, Weisskoff RM. Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging. Magn Reson Med 2005;54:1377-1386. – reference: Chan LL, Rumpel H, Yap K, et al. Case control study of diffusion tensor imaging in Parkinson's disease. J Neurol Neurosurg Psychiatry 2007;78:1383-1386. – reference: Paulus W, Jellinger K. The neuropathologic basis of different clinical subgroups of Parkinson's disease. J Neuropathol Exp Neurol 1991;50:743-755. – reference: Beaulieu C. The basis of anisotropic water diffusion in the nervous system-a technical review. NMR Biomed 2002;15:435-455. – volume: 77 start-page: 269 year: 2011 end-page: 273 article-title: Voxel‐based analysis of diffusion tensor indices in the brain in patients with Parkinson's disease publication-title: Eur J Radiol – volume: 78 start-page: 1176 year: 2007 end-page: 1181 article-title: Dementia with Lewy bodies: a comparison of clinical diagnosis, FP‐CIT single photon emission computed tomography imaging and autopsy publication-title: J Neurol Neurosurg Psychiatry – volume: 15 start-page: 435 year: 2002 end-page: 455 article-title: The basis of anisotropic water diffusion in the nervous system—a technical review publication-title: NMR Biomed – volume: 28 start-page: 668 year: 2013 end-page: 670 article-title: How to identify tremor dominant and postural instability/gait difficulty groups with the Movement Disorder Society Unified Parkinson's Disease Rating Scale: comparison with the Unified Parkinson's Disease Rating Scale publication-title: Mov Disord – volume: 201 start-page: 637 year: 1996 end-page: 648 article-title: Diffusion tensor MR imaging of the human brain publication-title: Radiology – volume: 19 start-page: 716 year: 1974 end-page: 723 article-title: A new look at the statistical model identification publication-title: IEEE Trans Automat Contr – volume: 29 start-page: 1064 issue: Suppl 1 year: 2014 article-title: Can we reliably establish Parkinson disease subtypes in de novo patients: follow‐up results from the PPMI study [abstract] publication-title: 18th International Congress of Parkinson's Disease and Movement Disorders – volume: 72 start-page: 1378 year: 2009 end-page: 1384 article-title: High‐resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease publication-title: Neurology – volume: 78 start-page: 1383 year: 2007 end-page: 1386 article-title: Case control study of diffusion tensor imaging in Parkinson's disease publication-title: J Neurol Neurosurg Psychiatry – volume: 43 start-page: 829 year: 1993 end-page: 830 article-title: Prognostic significance of the onset mode in parkinsonism publication-title: Neurology – volume: 50 start-page: 743 year: 1991 end-page: 755 article-title: The neuropathologic basis of different clinical subgroups of Parkinson's disease publication-title: J Neuropathol Exp Neurol – volume: 80 start-page: 857 year: 2013 end-page: 864 article-title: Diffusion tensor imaging in parkinsonian syndromes: a systematic review and meta‐analysis publication-title: Neurology – volume: 40 start-page: 885 year: 2003 end-page: 895 article-title: Diffusion MRI of complex neural architecture publication-title: Neuron – volume: 35 start-page: 831 year: 2014 end-page: 846 article-title: Voxelwise multivariate analysis of multimodality magnetic resonance imaging publication-title: Hum Brain Mapp – volume: 271 start-page: 831 year: 2014 end-page: 838 article-title: MR imaging of the substantia nigra at 7 T enables diagnosis of Parkinson disease publication-title: Radiology – volume: 95 start-page: 629 year: 2011 end-page: 635 article-title: The Parkinson Progression Marker Initiative (PPMI) publication-title: Prog Neurobiol – volume: 17 start-page: 427 year: 1967 end-page: 442 article-title: Parkinsonism: onset, progression and mortality publication-title: Neurology – volume: 47 start-page: 435 year: 2009 end-page: 441 article-title: MRI characteristics of the substantia nigra in Parkinson's disease: a combined quantitative T1 and DTI study publication-title: Neuroimage – volume: 3 start-page: 481 year: 2013 end-page: 488 article-title: Diffusion tensor imaging of nigral degeneration in Parkinson's disease: a region‐of‐interest and voxel‐based study at 3 T and systematic review with meta‐analysis publication-title: Neuroimage Clin – volume: 18 start-page: 1029 year: 2012 end-page: 1033 article-title: Asymmetrical diffusion tensor imaging indices of the rostral substantia nigra in Parkinson's disease publication-title: Parkinsonism Relat Disord – volume: 27 start-page: 1636 year: 2012 end-page: 1643 article-title: Imaging nigral pathology and clinical progression in Parkinson's disease publication-title: Mov Disord – volume: 26 start-page: 590 year: 2007 end-page: 596 article-title: Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease publication-title: Neurobiol Dis – volume: 54 start-page: 1377 year: 2005 end-page: 1386 article-title: Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging publication-title: Magn Reson Med – volume: 23 start-page: 2129 year: 2008 end-page: 2170 article-title: Movement Disorder Society‐sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS‐UPDRS): scale presentation and clinimetric testing results publication-title: Mov Disord – ident: e_1_2_8_15_1 doi: 10.1016/j.parkreldis.2012.05.021 – ident: e_1_2_8_19_1 doi: 10.1136/jnnp.2007.121525 – volume: 29 start-page: 1064 issue: 1 year: 2014 ident: e_1_2_8_23_1 article-title: Can we reliably establish Parkinson disease subtypes in de novo patients: follow‐up results from the PPMI study [abstract] publication-title: 18th International Congress of Parkinson's Disease and Movement Disorders – ident: e_1_2_8_2_1 doi: 10.1016/j.pneurobio.2011.09.005 – ident: e_1_2_8_20_1 doi: 10.1016/j.ejrad.2009.07.032 – ident: e_1_2_8_5_1 doi: 10.1212/WNL.0b013e318284070c – ident: e_1_2_8_13_1 doi: 10.1002/mds.22340 – ident: e_1_2_8_7_1 doi: 10.1016/j.nicl.2013.10.006 – ident: e_1_2_8_24_1 doi: 10.1002/mrm.20642 – ident: e_1_2_8_12_1 doi: 10.1109/TAC.1974.1100705 – ident: e_1_2_8_4_1 doi: 10.1212/01.wnl.0000340982.01727.6e – ident: e_1_2_8_14_1 doi: 10.1002/nbm.782 – ident: e_1_2_8_8_1 doi: 10.1136/jnnp.2006.110122 – ident: e_1_2_8_25_1 doi: 10.1016/S0896-6273(03)00758-X – ident: e_1_2_8_9_1 doi: 10.1212/WNL.17.5.427 – ident: e_1_2_8_21_1 doi: 10.1212/WNL.43.4.829 – ident: e_1_2_8_6_1 doi: 10.1016/j.neuroimage.2009.05.017 – ident: e_1_2_8_17_1 doi: 10.1148/radiol.14131448 – ident: e_1_2_8_3_1 doi: 10.1148/radiology.201.3.8939209 – ident: e_1_2_8_11_1 doi: 10.1002/hbm.22217 – ident: e_1_2_8_18_1 doi: 10.1016/j.nbd.2007.02.010 – ident: e_1_2_8_22_1 doi: 10.1097/00005072-199111000-00006 – ident: e_1_2_8_16_1 doi: 10.1002/mds.25182 – ident: e_1_2_8_10_1 doi: 10.1002/mds.25383 |
| SSID | ssj0011516 |
| Score | 2.3871596 |
| Snippet | ABSTRACT
Background
This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control... This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects from the... Background This study reports the baseline characteristics of diffusion tensor imaging data in Parkinson's disease (PD) patients and healthy control subjects... |
| SourceID | proquest pubmed crossref wiley istex |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1885 |
| SubjectTerms | Aged Diffusion Tensor Imaging Disease Progression dopamine Dopamine - metabolism Female fractional anisotropy Humans Image Processing, Computer-Assisted Male Middle Aged Movement disorders neuroimaging Neurologic Examination Parkinson Disease - metabolism Parkinson Disease - physiopathology substantia nigra Substantia Nigra - metabolism Substantia Nigra - physiopathology |
| Title | Diffusion imaging of nigral alterations in early Parkinson's disease with dopaminergic deficits |
| URI | https://api.istex.fr/ark:/67375/WNG-HHZDGZ3F-H/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmds.26325 https://www.ncbi.nlm.nih.gov/pubmed/26260437 https://www.proquest.com/docview/1757579857 https://www.proquest.com/docview/1760897579 https://www.proquest.com/docview/1780517684 |
| Volume | 30 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9RAEF9KBfFF62fTVllFtC-5pvuRZPFJPK9BuD6oxVKEJbvZlaCXK80dSP_6zmw-pFJFJC-BzCb7NZnf7uz8hpCXqvKq5KmJwRZVsEAp07ishIkV2OIMPXFlhtHI8-O0OBEfTuXpBnkzxMJ0_BDjhhtqRvhfo4KXpj34RRq6qNoJko1jgPkhT5E3f_pxpI4CoBPSnoISyRAhPLAKJexgLHnNFt3Cbv15E9C8jluD4ZndI1-HKnfnTb5P1iszsZe_sTn-Z5u2yN0ekNK33Qy6TzZc84Dcnvcu94dET2vv17inRutFSGlEl5429bcLKBV87d2eH60b6pAtmWIgdYgpe93S3v9DcbuXVrBAX4Rgw9rSyiF3xap9RE5m7z-_K-I-K0NshRIyFsx6gImOW-EY8xVL7KG3iRWZS1KnmC-N4cpkUsoq9QmvEJWpzFmTeJZJxR-TzWbZuG1CWaZggZk7I4QXxgJUFbLkljt4oTKqjMj-MD7a9pTlmDnjh-7IlpmGDtOhwyLyYhQ973g6bhJ6FQZ5lID-wINtmdRfjo90UZxNj874TBcR2Rtmge51utUAtOBSucwi8nx8DNqILpayccs1yqRJrlDsbzI5EqOluYjIk26GjRViuL4UHL6wH-bJn9ui59NP4Wbn30V3yR3Ae7I7jbNHNlcXa_cUMNXKPAvKcwX8Uhv6 |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VVgIuvB-BAgYh6CXbkNhJLHFBLNsA3T1Aq1aVkBU7Nopgs6i7KyF-PTPOAxUVhFAukTJO_Jr4mxnPZ4CnsnKyTFId4lpUoYFSpmFZcR1KXIszisSVGWUjT2dpccjfHYvjDXjZ58K0_BCDw400w_-vScHJIb37izV0Xi1HxDYuLsAWR6BBptf4w0AehVDHH3yKaiR8jnDPKxTFu0PRM6vRFnXs9_Og5lnk6peeyVX41Fe63XHyZbRe6ZH58Ruf4_-26hpc6TApe9VOouuwYZsbcHHaRd1vghrXzq3JrcbquT_ViC0ca-rPp1jKh9tbtx-rG2aJMJlRLrVPK3u-ZF0IiJHHl1Voo899vmFtWGWJvmK1vAWHkzcHr4uwO5ghNFxyEfLYOESKNjHcxrGr4si8cCYyPLNRamXsSq0TqTMhRJW6KKkImMnMGh25OBMyuQ2bzaKxd4HFmUQbM7eac8e1QbTKRZmYxOILpZZlADv9ACnTsZbT4RlfVcu3HCvsMOU7LIAng-i3lqrjPKFnfpQHCewP2tuWCXU021NFcTLeO0kmqghgu58GqlPrpUKshZfMRRbA4-ExKiRFWcrGLtYkk0a5JLG_yeTEjZbmPIA77RQbKhSTickT_MKOnyh_bouajj_6m3v_LvoILhUH0321_3b2_j5cRvgn2s0527C5Ol3bBwixVvqh16SfswggGQ |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3di9QwEB_OOzh88fujemoU0XvpXk2TdoNP4rpXP3YR9bjjEEKTJlJ0u8ftLoh_vTNpt3JyikhfCp20yWSm-SWT-QXgsaq8KtPMxDgWVThBKbO4rISJFY7FOUXiypyykSfTrDgQb47k0QY8X-fCtPwQ_YIbeUb4X5ODn1R-7xdp6KxaDIhsXF6ALZEhkiBE9KHnjkKkE849RS-SIUV4TSuU8L2-6JnBaIv0-v08pHkWuIaRZ3wZPq_r3G44-TpYLc3A_viNzvE_G3UFLnWIlL1oTegqbLjmGmxPupj7ddCj2vsVLaqxehbONGJzz5r6yymWCsH2dtGP1Q1zRJfMKJM6JJU9XbAuAMRovZdVOEOfhWzD2rLKEXnFcnEDDsavPr0s4u5YhtgKJWQsuPWIE11qhePcVzyxz7xNrMhdkjnFfWlMqkwupawyn6QVwTKVO2sSz3Op0puw2cwbdxsYzxXOMIfOCOGFsYhVhSxTmzp8oTKqjGB33T_adpzldHTGN92yLXONCtNBYRE86kVPWqKO84SehE7uJVAftLMtl_pwuq-L4ni0f5yOdRHBztoKdOfUC41ICy81lHkED_vH6I4UYykbN1-RDJqiIrG_yQyJGS0bighutRbWV4jTBFOk-IXdYCd_bouejD6Gmzv_LvoAtt-Pxvrd6-nbu3ARsZ9sd-bswObydOXuIb5amvvBj34CPBQeyA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Diffusion+imaging+of+nigral+alterations+in+early+Parkinson%27s+disease+with+dopaminergic+deficits&rft.jtitle=Movement+disorders&rft.au=Schuff%2C+Norbert&rft.au=Wu%2C+I-Wei&rft.au=Buckley%2C+Shannon&rft.au=Foster%2C+Eric+D&rft.date=2015-12-01&rft.eissn=1531-8257&rft.volume=30&rft.issue=14&rft.spage=1885&rft_id=info:doi/10.1002%2Fmds.26325&rft_id=info%3Apmid%2F26260437&rft.externalDocID=26260437 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0885-3185&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0885-3185&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0885-3185&client=summon |