Social isolation-induced increase in NMDA receptors in the hippocampus exacerbates emotional dysregulation in mice

• Published in: Hippocampus Vol. 25; no. 4; pp. 474 - 485
• Main Authors: Chang, Chih-Hua, Hsiao, Ya-Hsin, Chen, Yu-Wen, Yu, Yang-Jung, Gean, Po-Wu
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.04.2015; Wiley Subscription Services, Inc
• Subjects: acute stress; Affective Symptoms - etiology; Affective Symptoms - pathology; aggression; Aggression - physiology; Animals; Animals, Newborn; depression; Dizocilpine Maleate - pharmacology; Excitatory Amino Acid Antagonists - pharmacology; Excitatory Postsynaptic Potentials - drug effects; Exploratory Behavior - physiology; Gene Expression Regulation - physiology; Hippocampus - cytology; Hippocampus - metabolism; Male; Membrane Potentials - drug effects; Membrane Potentials - physiology; Mice; Mice, Inbred C57BL; Neurons - drug effects; Neurons - physiology; NMDA receptor; Piperidines - pharmacology; Prepulse Inhibition - drug effects; Prepulse Inhibition - physiology; Random Allocation; Receptors, N-Methyl-D-Aspartate - metabolism; Reflex, Startle - physiology; social isolation; Social Isolation - psychology; Swimming - psychology; Synaptosomes - drug effects; Synaptosomes - metabolism; social isolation; aggression; depression; NMDA receptor; acute stress

ABSTRACT Epidemiological studies have shown that early life adverse events have long‐term effects on the susceptibility to subsequent stress exposure in adolescence, but the precise mechanism is unclear. In the present study, mice on postnatal day 21–28 were randomly assigned to either a group or is...