Pre-diagnostic genotyping identifies T1D subjects with impaired Treg IL-2 signaling and an elevated proportion of FOXP3+IL-17+ cells

• Published in: Genes and immunity Vol. 18; no. 1; pp. 15 - 21
• Main Authors: Marwaha, A K, Panagiotopoulos, C, Biggs, C M, Staiger, S, Del Bel, K L, Hirschfeld, A F, Priatel, J J, Turvey, S E, Tan, R
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2017; Nature Publishing Group
• Subjects: 13/31; 38; 631/208/728; 631/250/2152; Biomarkers - metabolism; Biomedical and Life Sciences; Biomedicine; Cancer Research; Comparative analysis; Cytokines; Diabetes; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - diagnosis; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Diagnosis; Flow Cytometry; Forkhead Transcription Factors - genetics; Foxp3 protein; Gene Expression; Genes; Genetic aspects; Genotype; Genotype & phenotype; Genotyping; Health aspects; Helper cells; Human Genetics; Humans; Immune Tolerance; Immunological tolerance; Immunology; Immunoregulation; Inflammation; Interleukin 17; Interleukin 2; Interleukin 2 receptors; Interleukin-17 - genetics; Interleukin-2 - genetics; Interleukins; Lymphocytes; Lymphocytes T; original-article; Pathogenesis; Pathology; Pediatrics; Phenotypes; Phosphorylation; Physiological aspects; Prognosis; Signal Transduction; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Suppressor cells; T-Lymphocytes, Regulatory - immunology; Th17 Cells; Type 1 diabetes; Variance analysis; Canada; Qatar; British Columbia Canada

T-regulatory cells (Tregs) are essential for immune tolerance, and animal studies implicate their dysfunction in type 1 diabetes (T1D) pathogenesis. Tregs require interleukin-2 (IL-2) for their suppressive function, and variants in IL-2/IL-2R pathway genes have been associated with T1D. We previousl...