L503F variant of carnitine/organic cation transporter 1 efficiently transports metformin and other biguanides - Futatsugi, Azusa; Masuo, Yusuke; Kawabata, Shiori; Nakamichi, Noritaka; Kato, Yukio (Journal of pharmacy and pharmacology, 2016)
Keywords: Amines - metabolism; Amines - pharmacokinetics; Asian Continental Ancestry Group; Biguanides - metabolism; Biguanides - pharmacokinetics; Biological Transport, Active; Buformin - metabolism; Buformin - pharmacokinetics; Carnitine - metabolism; Cyclohexanecarboxylic Acids - metabolism; Cyclohexanecarboxylic Acids - pharmacokinetics; Ergothioneine - metabolism; Ergothioneine - pharmacokinetics; European Continental Ancestry Group; gamma-Aminobutyric Acid - metabolism; gamma-Aminobutyric Acid - pharmacokinetics; HEK293 Cells; Humans; Intestinal Absorption; Metformin - metabolism; Metformin - pharmacokinetics; Organic Cation Transporter 1 - genetics; Organic Cation Transporter 1 - metabolism; Polymorphism, Single Nucleotide; biguanide; metformin; single nucleotide polymorphism; cytotoxicity; organic cation transporter