Anti‐CD40L therapy prevents the formation of precursor lesions to gastric B‐cell MALT lymphoma in a mouse model

• Published in: The Journal of pathology Vol. 259; no. 4; pp. 402 - 414
• Main Authors: Ying, Le, Liu, Phoebe, Ding, Zhoujie, Wray‐McCann, Georgie, Emery, Jack, Colon, Nina, Le, Lena HM, Tran, Le Son, Xu, Ping, Yu, Liang, Philpott, Dana J, Tu, Yugang, Cheah, Daryl MZ, Cheng, Chee L, Lim, Soon T, Ong, Choon K, Ferrero, Richard L
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.04.2023; Wiley Subscription Services, Inc
• Subjects: Animal models; Animals; Antibodies; Apoptosis; APRIL; B-Lymphocytes; BAFF; B‐cell; CD4 antigen; CD40 Ligand; CD40L protein; CD8 antigen; Cell culture; Chronic infection; Dendritic cells; Forkhead Transcription Factors - metabolism; Foxp3 protein; Helicobacter; Helicobacter Infections - complications; Helicobacter Infections - drug therapy; Helicobacter pylori - genetics; Immune checkpoint; Infections; Intracellular Signaling Peptides and Proteins - metabolism; Lesions; Lymphoid tissue; Lymphoma; Lymphoma, B-Cell, Marginal Zone - drug therapy; Lymphoma, B-Cell, Marginal Zone - genetics; Lymphoma, B-Cell, Marginal Zone - prevention & control; Macrophages; Malignancy; MALT lymphoma; Medicin och hälsovetenskap; Mice; Microenvironments; Mucosal-associated lymphoid tissue; multiplex immunohistochemistry; NLRC5; Original; PD-L1 protein; PD‐L1; Stomach Neoplasms - pathology; Therapeutic targets; Tumor Microenvironment; Tumors; BAFF; multiplex immunohistochemistry; MALT lymphoma; B-cell; Helicobacter; CD40 ligand; NLRC5; PD-L1; APRIL

Mucosa‐associated lymphoid tissue (MALT) lymphoma is a B‐cell tumour that develops over many decades in the stomachs of individuals with chronic Helicobacter pylori infection. We developed a new mouse model of human gastric MALT lymphoma in which mice with a myeloid‐specific deletion of the innate i...