Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles

• Published in: Journal of pharmaceutical sciences Vol. 90; no. 12; pp. 1927 - 1936
• Main Authors: Hillyer, Julián F., Albrecht, Ralph M.
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.12.2001; John Wiley & Sons, Inc; Wiley; American Pharmaceutical Association
• Subjects: absorption; Administration, Oral; Animals; Biological and medical sciences; colloidal gold; Digestive System - metabolism; Digestive System - ultrastructure; electron microscopy; General pharmacology; Gold Colloid - administration & dosage; Gold Colloid - pharmacokinetics; Ileum - metabolism; Ileum - ultrastructure; Intestinal Absorption; Intestinal Mucosa - metabolism; Intestinal Mucosa - ultrastructure; Medical sciences; Mice; Mice, Inbred BALB C; Microspheres; nanoparticle; Nanotechnology; neutron activation; Particle Size; persorption; Pharmaceutical technology. Pharmaceutical industry; Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions; Pharmacology. Drug treatments; Tissue Distribution; neutron activation; electron microscopy; nanoparticle; colloidal gold; absorption; persorption; Neutron activation analysis; Particle size; Pharmaceutical technology; Digestive system; Nanoparticle; Persorption; Rodentia; Gut; Oral administration; Drug carrier; Vertebrata; Mammalia; Absorption; Mouse; Animal; Distribution; Dosage form

The gastrointestinal uptake of micro‐ and nanoparticles has been the subject of recent efforts to develop effective carriers that enhance the oral uptake of drugs and vaccines. Here, we used correlative instrumental neutron activation analysis and electron microscopy to quantitatively and qualitativ...