Development of an acute model of inhalational melioidosis in the common marmoset (Callithrix jacchus)

• Published in: International journal of experimental pathology Vol. 92; no. 6; pp. 428 - 435
• Main Authors: Nelson, Michelle, Dean, Rachel E., Salguero, Francisco J., Taylor, Christopher, Pearce, Peter C., Simpson, Andrew J. H., Lever, Mark S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2011
• Subjects: Acute Disease; Administration, Inhalation; animal model; Animal models; Animals; Bacteremia; Body temperature; Body Temperature - physiology; Burkholderia pseudomallei; Burkholderia pseudomallei - isolation & purification; Callithrix; Callithrix jacchus; Culling; Disease Models, Animal; Disease Progression; Female; Infection; Lethality; Liver; Liver - microbiology; Liver - pathology; Lung; Lung - microbiology; Lung - pathology; Male; marmoset; Melioidosis; Melioidosis - microbiology; Melioidosis - pathology; Melioidosis - physiopathology; non-human primate; Original; pathology; Spleen; Spleen - microbiology; Spleen - pathology; Time Factors

Summary Studies of inhalational melioidosis were undertaken in the common marmoset (Callithrix jacchus). Following exposure to an inhaled challenge with aerosolized Burkholderia pseudomallei, lethal infection was observed in marmosets challenged with doses below 10 cfu; a precise LD50 determination...