Bile salt export pump: a sensitive and specific immunohistochemical marker of hepatocellular carcinoma

• Published in: Histopathology Vol. 66; no. 4; pp. 598 - 602
• Main Authors: Lagana, Stephen M, Salomao, Marcela, Remotti, Helen E, Knisely, A.S., Moreira, Roger K
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.03.2015; Wiley Subscription Services, Inc
• Subjects: Aged; Antigens; ATP Binding Cassette Subfamily B Member 11; ATP-Binding Cassette Transporters - metabolism; Bile; Bile Duct Neoplasms - diagnosis; Bile Duct Neoplasms - metabolism; Bile Duct Neoplasms - pathology; Bile Ducts, Intrahepatic - metabolism; Bile Ducts, Intrahepatic - pathology; bile salt export pump; Biomarkers, Tumor - metabolism; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cholangiocarcinoma - diagnosis; Cholangiocarcinoma - metabolism; Cholangiocarcinoma - pathology; Diagnosis, Differential; Female; hepatocellular carcinoma; Humans; Immunohistochemistry; Liver cancer; Liver Neoplasms - diagnosis; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Middle Aged; Sensitivity and Specificity; Tumors; bile salt export pump; hepatocellular carcinoma; immunohistochemistry

Aims Bile salt export pump (BSEP) is a transporter expressed exclusively at hepatic canaliculi and drives bile‐salt efflux. Minimal data exist about BSEP expression in tumours. We hypothesized that BSEP immunohistochemistry would be specific for hepatocellular carcinoma (HCC). Methods and results Ti...