Bile salt export pump: a sensitive and specific immunohistochemical marker of hepatocellular carcinoma
Aims Bile salt export pump (BSEP) is a transporter expressed exclusively at hepatic canaliculi and drives bile‐salt efflux. Minimal data exist about BSEP expression in tumours. We hypothesized that BSEP immunohistochemistry would be specific for hepatocellular carcinoma (HCC). Methods and results Ti...
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Published in | Histopathology Vol. 66; no. 4; pp. 598 - 602 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.03.2015
Wiley Subscription Services, Inc |
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Abstract | Aims
Bile salt export pump (BSEP) is a transporter expressed exclusively at hepatic canaliculi and drives bile‐salt efflux. Minimal data exist about BSEP expression in tumours. We hypothesized that BSEP immunohistochemistry would be specific for hepatocellular carcinoma (HCC).
Methods and results
Tissue microarrays, including 48 HCC, 41 cholangiocarcinomas and 24 metastatic tumours in liver, were immunostained for BSEP. Expression was compared with common markers of hepatocytic differentiation including CD10, hepatocyte paraffin‐1 antigen (HepPar‐1), carcinoembryonic antigen, arginase‐1 (ARG) and glypican‐3 (GPC‐3). BSEP expression was assessed in normal tissues. Special attention was given to adrenal gland (normal and neoplasia). BSEP was easy to interpret and showed no background staining. Canalicular expression was seen in all normal livers, but not in other normal tissue. BSEP was 90% sensitive and 100% specific for HCC (canalicular in 33 of 43 positive cases). The sensitivity of ARG was slightly higher, but specificity was slightly lower (94% for both). HepPar‐1 was 90% sensitive and 97% specific. CD10, polyclonal carcinoembryonic antigen (pCEA) and GPC‐3 all had lower sensitivity (74, 81 and 54%, respectively).
Conclusions
In malignant tumours in the liver, BSEP marking was 100% specific and 90% sensitive for HCC. The specificity of BSEP for HCC obviates the need to identify a ‘canalicular’ pattern, which can limit the utility of other canalicular markers. |
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AbstractList | Bile salt export pump (BSEP) is a transporter expressed exclusively at hepatic canaliculi and drives bile-salt efflux. Minimal data exist about BSEP expression in tumours. We hypothesized that BSEP immunohistochemistry would be specific for hepatocellular carcinoma (HCC).
Tissue microarrays, including 48 HCC, 41 cholangiocarcinomas and 24 metastatic tumours in liver, were immunostained for BSEP. Expression was compared with common markers of hepatocytic differentiation including CD10, hepatocyte paraffin-1 antigen (HepPar-1), carcinoembryonic antigen, arginase-1 (ARG) and glypican-3 (GPC-3). BSEP expression was assessed in normal tissues. Special attention was given to adrenal gland (normal and neoplasia). BSEP was easy to interpret and showed no background staining. Canalicular expression was seen in all normal livers, but not in other normal tissue. BSEP was 90% sensitive and 100% specific for HCC (canalicular in 33 of 43 positive cases). The sensitivity of ARG was slightly higher, but specificity was slightly lower (94% for both). HepPar-1 was 90% sensitive and 97% specific. CD10, polyclonal carcinoembryonic antigen (pCEA) and GPC-3 all had lower sensitivity (74, 81 and 54%, respectively).
In malignant tumours in the liver, BSEP marking was 100% specific and 90% sensitive for HCC. The specificity of BSEP for HCC obviates the need to identify a 'canalicular' pattern, which can limit the utility of other canalicular markers. Aims Bile salt export pump (BSEP) is a transporter expressed exclusively at hepatic canaliculi and drives bile‐salt efflux. Minimal data exist about BSEP expression in tumours. We hypothesized that BSEP immunohistochemistry would be specific for hepatocellular carcinoma (HCC). Methods and results Tissue microarrays, including 48 HCC, 41 cholangiocarcinomas and 24 metastatic tumours in liver, were immunostained for BSEP. Expression was compared with common markers of hepatocytic differentiation including CD10, hepatocyte paraffin‐1 antigen (HepPar‐1), carcinoembryonic antigen, arginase‐1 (ARG) and glypican‐3 (GPC‐3). BSEP expression was assessed in normal tissues. Special attention was given to adrenal gland (normal and neoplasia). BSEP was easy to interpret and showed no background staining. Canalicular expression was seen in all normal livers, but not in other normal tissue. BSEP was 90% sensitive and 100% specific for HCC (canalicular in 33 of 43 positive cases). The sensitivity of ARG was slightly higher, but specificity was slightly lower (94% for both). HepPar‐1 was 90% sensitive and 97% specific. CD10, polyclonal carcinoembryonic antigen (pCEA) and GPC‐3 all had lower sensitivity (74, 81 and 54%, respectively). Conclusions In malignant tumours in the liver, BSEP marking was 100% specific and 90% sensitive for HCC. The specificity of BSEP for HCC obviates the need to identify a ‘canalicular’ pattern, which can limit the utility of other canalicular markers. Aims Bile salt export pump (BSEP) is a transporter expressed exclusively at hepatic canaliculi and drives bile-salt efflux. Minimal data exist about BSEP expression in tumours. We hypothesized that BSEP immunohistochemistry would be specific for hepatocellular carcinoma (HCC). Methods and results Tissue microarrays, including 48 HCC, 41 cholangiocarcinomas and 24 metastatic tumours in liver, were immunostained for BSEP. Expression was compared with common markers of hepatocytic differentiation including CD10, hepatocyte paraffin-1 antigen (HepPar-1), carcinoembryonic antigen, arginase-1 (ARG) and glypican-3 (GPC-3). BSEP expression was assessed in normal tissues. Special attention was given to adrenal gland (normal and neoplasia). BSEP was easy to interpret and showed no background staining. Canalicular expression was seen in all normal livers, but not in other normal tissue. BSEP was 90% sensitive and 100% specific for HCC (canalicular in 33 of 43 positive cases). The sensitivity of ARG was slightly higher, but specificity was slightly lower (94% for both). HepPar-1 was 90% sensitive and 97% specific. CD10, polyclonal carcinoembryonic antigen (pCEA) and GPC-3 all had lower sensitivity (74, 81 and 54%, respectively). Conclusions In malignant tumours in the liver, BSEP marking was 100% specific and 90% sensitive for HCC. The specificity of BSEP for HCC obviates the need to identify a 'canalicular' pattern, which can limit the utility of other canalicular markers. |
Author | Remotti, Helen E Salomao, Marcela Knisely, A.S. Moreira, Roger K Lagana, Stephen M |
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Cites_doi | 10.1080/00313020701716391 10.1016/S0002-9440(10)62528-X 10.1158/1078-0432.CCR-05-0278 10.1016/S0016-5085(03)00689-9 10.1097/PAI.0b013e3182642c9c 10.1309/KC09YTF2M4DLUYQ6 10.1097/PAS.0b013e3181e5dffa 10.1002/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO;2-E 10.1309/AJCPUD0P5NQBOYPK 10.1016/j.acthis.2011.10.003 10.1038/3034 10.1097/00000658-199909000-00004 10.1038/labinvest.3700699 10.1001/archsurg.141.10.1000 10.1186/1746-1596-7-149 |
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Invest. contributor: fullname: Knisely A – ident: e_1_2_6_14_1 doi: 10.1158/1078-0432.CCR-05-0278 – ident: e_1_2_6_5_1 doi: 10.1016/S0016-5085(03)00689-9 – volume: 21 start-page: 254 year: 2013 ident: e_1_2_6_7_1 article-title: Glutamine synthetase, heat shock protein‐70, and glypican‐3 in intrahepatic cholangiocarcinoma and tumors metastatic to liver publication-title: Appl. Immunohistochem. Mol. Morphol. doi: 10.1097/PAI.0b013e3182642c9c contributor: fullname: Lagana SM – ident: e_1_2_6_16_1 doi: 10.1309/KC09YTF2M4DLUYQ6 – ident: e_1_2_6_4_1 doi: 10.1097/PAS.0b013e3181e5dffa – ident: e_1_2_6_11_1 doi: 10.1002/1097-0142(195405)7:3<462::AID-CNCR2820070308>3.0.CO;2-E – volume: 143 start-page: 1050 year: 1993 ident: e_1_2_6_2_1 article-title: Hepatocyte paraffin 1: a monoclonal antibody that reacts with hepatocytes and can be used for differential diagnosis of hepatic tumors publication-title: Am. J. Pathol. contributor: fullname: Wennerberg AE – volume: 463 start-page: 148 year: 2013 ident: e_1_2_6_20_1 article-title: HepPar‐1 and arginase‐1 in small intestinal and ampullary adenocarcinoma publication-title: Virchows Arch. contributor: fullname: Lagana SM – ident: e_1_2_6_8_1 – ident: e_1_2_6_15_1 doi: 10.1309/AJCPUD0P5NQBOYPK – ident: e_1_2_6_6_1 doi: 10.1016/j.acthis.2011.10.003 – ident: e_1_2_6_9_1 doi: 10.1038/3034 – ident: e_1_2_6_18_1 doi: 10.1097/00000658-199909000-00004 – ident: e_1_2_6_12_1 doi: 10.1038/labinvest.3700699 – ident: e_1_2_6_19_1 doi: 10.1001/archsurg.141.10.1000 – ident: e_1_2_6_17_1 doi: 10.1186/1746-1596-7-149 |
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Bile salt export pump (BSEP) is a transporter expressed exclusively at hepatic canaliculi and drives bile‐salt efflux. Minimal data exist about BSEP... Bile salt export pump (BSEP) is a transporter expressed exclusively at hepatic canaliculi and drives bile-salt efflux. Minimal data exist about BSEP expression... Aims Bile salt export pump (BSEP) is a transporter expressed exclusively at hepatic canaliculi and drives bile-salt efflux. Minimal data exist about BSEP... |
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SubjectTerms | Aged Antigens ATP Binding Cassette Subfamily B Member 11 ATP-Binding Cassette Transporters - metabolism Bile Bile Duct Neoplasms - diagnosis Bile Duct Neoplasms - metabolism Bile Duct Neoplasms - pathology Bile Ducts, Intrahepatic - metabolism Bile Ducts, Intrahepatic - pathology bile salt export pump Biomarkers, Tumor - metabolism Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cholangiocarcinoma - diagnosis Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology Diagnosis, Differential Female hepatocellular carcinoma Humans Immunohistochemistry Liver cancer Liver Neoplasms - diagnosis Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Middle Aged Sensitivity and Specificity Tumors |
Title | Bile salt export pump: a sensitive and specific immunohistochemical marker of hepatocellular carcinoma |
URI | https://api.istex.fr/ark:/67375/WNG-NSZD7HXB-B/fulltext.pdf https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fhis.12601 https://www.ncbi.nlm.nih.gov/pubmed/25378077 https://www.proquest.com/docview/1652314533 |
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