Effect of Low- and High-Fat Meals on the Pharmacokinetics of Venetoclax, a Selective First-in-Class BCL-2 Inhibitor

• Published in: Journal of clinical pharmacology Vol. 56; no. 11; p. 1355
• Main Authors: Salem, Ahmed Hamed, Agarwal, Suresh K, Dunbar, Martin, Nuthalapati, Silpa, Chien, David, Freise, Kevin J, Wong, Shekman L
• Format: Journal Article
• Language: English
• Published: England 01.11.2016
• Subjects: Adult; Antineoplastic Agents - blood; Antineoplastic Agents - pharmacokinetics; Bridged Bicyclo Compounds, Heterocyclic - blood; Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics; Cross-Over Studies; Diet, Fat-Restricted - methods; Diet, High-Fat - methods; Dietary Fats - blood; Female; Food-Drug Interactions - physiology; Humans; Male; Middle Aged; Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors; Sulfonamides - blood; Sulfonamides - pharmacokinetics; BCL-2; CLL; NHL; food effect; bioavailability; fat; pharmacokinetics; venetoclax

Venetoclax is a selective, first-in-class, B-cell lymphoma-2 inhibitor that has demonstrated clinical efficacy in several hematological malignancies. Two studies evaluated the relative bioavailability of venetoclax in healthy subjects: (1) a bioequivalence study to compare the bioavailability of the...