Effect of Low- and High-Fat Meals on the Pharmacokinetics of Venetoclax, a Selective First-in-Class BCL-2 Inhibitor - Salem, Ahmed Hamed; Agarwal, Suresh K; Dunbar, Martin; Nuthalapati, Silpa; Chien, David; Freise, Kevin J; Wong, Shekman L (Journal of clinical pharmacology, 2016)
Keywords: Adult; Antineoplastic Agents - blood; Antineoplastic Agents - pharmacokinetics; Bridged Bicyclo Compounds, Heterocyclic - blood; Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics; Cross-Over Studies; Diet, Fat-Restricted - methods; Diet, High-Fat - methods; Dietary Fats - blood; Female; Food-Drug Interactions - physiology; Humans; Male; Middle Aged; Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors; Sulfonamides - blood; Sulfonamides - pharmacokinetics; BCL-2; CLL; NHL; food effect; bioavailability; fat; pharmacokinetics; venetoclax