Increased miR-195 aggravates neuropathic pain by inhibiting autophagy following peripheral nerve injury

• Published in: Glia Vol. 61; no. 4; pp. 504 - 512
• Main Authors: Shi, Guodong, Shi, Jiangang, Liu, Kun, Liu, Ning, Wang, Yuan, Fu, Zhiyi, Ding, Jiandong, Jia, Lianshun, Yuan, Wen
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.04.2013; Wiley Subscription Services, Inc
• Subjects: Animals; Autophagy; Autophagy - genetics; Cells, Cultured; Down-Regulation - genetics; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; Male; Medical research; Microglia - metabolism; Microglia - pathology; MicroRNAs - antagonists & inhibitors; MicroRNAs - biosynthesis; MicroRNAs - physiology; miR-195; Neuralgia - genetics; Neuralgia - metabolism; Neuralgia - pathology; neuroinflammation; neuropathic pain; Pain management; Peripheral Nerve Injuries - genetics; Peripheral Nerve Injuries - metabolism; Peripheral Nerve Injuries - pathology; peripheral nerve injury; Rats; Rats, Wistar; Up-Regulation - genetics

Following peripheral nerve injury (PNI) microglia proliferates and adopts inflammation that contributes to development and maintenance of neuropathic pain. miRNAs and autophagy are two important factors in the regulation of inflammation. However, little is known about whether miRNAs regulate neuroin...