Mechanisms underlying transient receptor potential ankyrin 1 (TRPA1)-mediated hyperalgesia and edema

• Published in: Journal of the peripheral nervous system Vol. 18; no. 1; pp. 62 - 74
• Main Authors: Perin-Martins, Andressa, Teixeira, Juliana Maia, Tambeli, Claudia H., Parada, Carlos Amílcar, Fischer, Luana
• Format: Journal Article
• Language: English
• Published: Malden, USA Wiley Periodicals, Inc 01.03.2013; Wiley Subscription Services, Inc
• Subjects: Acetanilides - toxicity; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide - pharmacology; Disease Models, Animal; Dose-Response Relationship, Drug; edema; Edema - chemically induced; Edema - complications; Edema - drug therapy; Extremities - pathology; Gene Expression Regulation - drug effects; hyperalgesia; Hyperalgesia - chemically induced; Hyperalgesia - drug therapy; Hyperalgesia - metabolism; Male; nociceptor sensitization; Oligodeoxyribonucleotides, Antisense - therapeutic use; Peptide Fragments - pharmacology; Peroxidase - metabolism; Piperazines - pharmacology; Purines - toxicity; Quinuclidines - pharmacology; Rats; Rats, Wistar; Serotonin Antagonists - pharmacology; TRPA1; TRPA1 Cation Channel; TRPC Cation Channels - antagonists & inhibitors; TRPC Cation Channels - metabolism

The aim of this study was to investigate the mechanisms that contribute to hyperalgesia and edema induced by TRPA1 activation. The injection of allyl isothiocyanate (AITC, 50, 100, or 300 µg/paw) into the rat's hind paw induced dose and time‐dependent hyperalgesia and edema, which were blocked...