Subgroups of multiple sclerosis patients with larger treatment benefits: a meta-analysis of randomized trials
Background and purpose No subgroups of patients with higher treatment effects have been clearly detected in multiple sclerosis (MS). The aim of the present work was to evaluate whether there are subgroups of relapsing−remitting MS (RRMS) patients who are more responsive to treatments. Methods All pu...
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Published in | European journal of neurology Vol. 22; no. 6; pp. 960 - 966 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.06.2015
John Wiley & Sons, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Background and purpose
No subgroups of patients with higher treatment effects have been clearly detected in multiple sclerosis (MS). The aim of the present work was to evaluate whether there are subgroups of relapsing−remitting MS (RRMS) patients who are more responsive to treatments.
Methods
All published randomized clinical trials in RRMS reporting a subgroup analysis of treatment effect were collected. Two main outcomes, the annualized relapse rate (ARR) and the disability progression, were studied. The treatment effect in each subgroup was reported as a relative effect (RE), defined as the treatment effect in the subgroup relative to the overall effect. A meta‐analysis was run to compare the RE between subgroups.
Results
Six trials (6693 RRMS patients) were included. Treatment effects on ARR were significantly higher in younger than in older subjects (RE = 0.83 vs. RE = 1.30, P < 0.001), in patients with than those without gadolinium activity (RE = 0.86 vs. RE = 1.15, P = 0.005) and in patients with lower than in those with higher Expanded Disability Status Scale (RE = 0.96 vs. RE = 1.23, P = 0.02), and on disability progression in younger than in older subjects (RE = 0.82 vs. RE = 1.28, P = 0.017).
Conclusions
This study formally shows that in RRMS higher treatment effects are associated with characteristics of earlier (lower age and Expanded Disability Status Scale) and more active (higher gadolinium activity) disease. |
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Bibliography: | ArticleID:ENE12690 Data S1. Simulation to calculate the standard error (SE) of the relative effect (RE) in each subgroup. Table S1. Effect of treatment on relapse rate according to demographic, clinical and MRI characteristics. Table S2. Effect of treatment on disability according to demographic, clinical and MRI characteristics. istex:797ADC999CDC123BFA57432C7D121C4AFA522D39 ark:/67375/WNG-7584SH8M-C ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 1351-5101 1468-1331 |
DOI: | 10.1111/ene.12690 |