AM251, a selective antagonist of the CB1 receptor, inhibits the induction of long-term potentiation and induces retrograde amnesia in rats

• Published in: Brain research Vol. 1075; no. 1; pp. 60 - 67
• Main Authors: de Oliveira Alvares, Lucas, Pasqualini Genro, Bruna, Vaz Breda, Ricardo, Pedroso, Michele Franzen, Costa Da Costa, Jaderson, Quillfeldt, Jorge Alberto
• Format: Journal Article
• Language: English
• Published: London Elsevier B.V 23.02.2006; Amsterdam Elsevier; New York, NY
• Subjects: AM251; Amnesia, Retrograde - chemically induced; Amnesia, Retrograde - physiopathology; Animals; Biological and medical sciences; CB1 cannabinoid receptor; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Excitatory Postsynaptic Potentials - drug effects; Excitatory Postsynaptic Potentials - physiology; Hippocampus; Hippocampus - drug effects; Hippocampus - physiology; Hippocampus - physiopathology; Long-Term Potentiation - drug effects; LTP; Male; Medical sciences; Memory; Nervous system (semeiology, syndromes); Neurology; Piperidines - pharmacology; Pyrazoles - pharmacology; Rats; Rats, Wistar; Reaction Time - drug effects; Receptor, Cannabinoid, CB1 - antagonists & inhibitors; CB1 cannabinoid receptor; LTP; AM251; Memory; Hippocampus; Potentiation; Memory disorder; Nervous system diseases; Rat; Rodentia; Central nervous system; Long term; Cerebral disorder; Encephalon; Vertebrata; Mammalia; Animal; Central nervous system disease; Synaptic plasticity; Amnesia; Antagonist; Neurological disorder; Memory LTP AM251 CB1 cannabinoid receptor Hippocampus

Long-term potentiation (LTP) has a long history as putative mechanism of memory formation, specially in the hippocampus, a structure essential for memory formation. Endocannabinoids are one of the endogenous systems that modulate this plasticity event: the activation of hippocampal CB1 receptors may...