The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 23; p. 5591
• Main Authors: Shen, Chieh-Yu, Lu, Cheng-Hsun, Wu, Cheng-Han, Li, Ko-Jen, Kuo, Yu-Min, Hsieh, Song-Chou, Yu, Chia-Li
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.11.2020; MDPI
• Subjects: advanced glycation end products; Age; Aging; Animals; Arthritis; Chronic illnesses; Diabetes; Diabetes Mellitus - drug therapy; Diabetes Mellitus - metabolism; Diabetes Mellitus - pathology; Disease; Gastrointestinal surgery; Glycation End Products, Advanced - antagonists & inhibitors; glyoxalase; Humans; Hyperglycemia; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - pathology; Inflammatory diseases; Insulin resistance; Maillard Reaction; Metabolic syndrome; Neurodegenerative Diseases - drug therapy; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Nε(carboxyethyl)-lysine; Nε-(carboxymethyl)-lysine; Obesity; Overweight; Oxidative stress; Physiology; Phytochemicals - pharmacology; Plasma; Proteins; Reactive oxygen species; Receptor for Advanced Glycation End Products - antagonists & inhibitors; receptor for AGEs; Review; Signal Transduction; Weight control; receptor for AGEs; AGE-related diseases; Nε-(carboxymethyl)-lysine; glyoxalase; Maillard reaction; Nε(carboxyethyl)-lysine; metabolic memory; advanced glycation end products; Maillard reaction inhibitor; AGE–RAGE axis signaling
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25235591

Advanced glycation end products (AGEs) are generated by nonenzymatic modifications of macromolecules (proteins, lipids, and nucleic acids) by saccharides (glucose, fructose, and pentose) via Maillard reaction. The formed AGE molecules can be catabolized and cleared by glyoxalase I and II in renal pr...