Biology and clinical relevance of EpCAM

• Published in: Cell Stress Vol. 3; no. 6; pp. 165 - 180
• Main Authors: Keller, Laura, Werner, Stefan, Pantel, Klaus
• Format: Journal Article
• Language: English
• Published: Austria Shared Science Publishers OG 21.05.2019
• Subjects: circulating tumor cells; EMT; EpCAM; Life Sciences; liquid biopsy; Review; Tumor biomarker; tumor cell dissemination; Tumor biomarker; EpCAM; circulating tumor cells; EMT; liquid biopsy; tumor cell dissemination

Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein primarily known to mediate homotypic cell contacts in epithelia tissues. Because EpCAM expression is limited to normal and malignant epithelia, it has been used as diagnostic marker for the detection of carcinoma cells in mese...