Infectious Diarrhea Due to Clostridium perfringens

In Clostridium perfringens food poisoning, an association between diarrhea and fecal enterotoxin is well established. Enterotoxin is found only in feces from symptomatic or infected persons and is absent from those of convalescent or healthy subjects. A rise in titer of antibody to the enterotoxin h...

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Published inThe Journal of infectious diseases Vol. 157; no. 2; pp. 390 - 391
Main Authors Larson, H. Elliott, Borriello, S. Peter
Format Journal Article
LanguageEnglish
Published United States The University of Chicago Press 01.02.1988
University of Chicago Press
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Abstract In Clostridium perfringens food poisoning, an association between diarrhea and fecal enterotoxin is well established. Enterotoxin is found only in feces from symptomatic or infected persons and is absent from those of convalescent or healthy subjects. A rise in titer of antibody to the enterotoxin has been documented, and administration of greater than or equal to 10 mg of purified enterotoxin to human volunteers produced diarrhea and abdominal pain. The authors have examined fecal specimens from cases of presumed infections diarrhea for the presence of bacterial exotoxins; earlier, they described the discovery of C. perfringens enterotoxin in 11 patients with presumed infectious diarrhea. This series has now been extended to 50 patients and confirms C. perfringens as a cause of infectious diarrhea unassociated with poisoning from food.
AbstractList In Clostridium perfringens food poisoning, an association between diarrhea and fecal enterotoxin is well established. Enterotoxin is found only in feces from symptomatic or infected persons and is absent from those of convalescent or healthy subjects. A rise in titer of antibody to the enterotoxin has been documented, and administration of greater than or equal to 10 mg of purified enterotoxin to human volunteers produced diarrhea and abdominal pain. The authors have examined fecal specimens from cases of presumed infections diarrhea for the presence of bacterial exotoxins; earlier, they described the discovery of C. perfringens enterotoxin in 11 patients with presumed infectious diarrhea. This series has now been extended to 50 patients and confirms C. perfringens as a cause of infectious diarrhea unassociated with poisoning from food.
Author Borriello, S. Peter
Larson, H. Elliott
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  givenname: S. Peter
  surname: Borriello
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  organization: Microbial Pathogenicity Research Group, Division of Communicable Diseases, Clinical Research Centre, Harrow, Middlesex, England
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Notes Please address requests for reprints to Dr. H. Elliott Larson, Microbial Pathogenicity Research Group, Division of Communicable Diseases, Clinical Research Centre, Watford Road, Harrow, Middlesex, England HA1 3UJ.
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SubjectTerms Adult
Aged
Aged, 80 and over
Antibodies
Clostridium Infections
Clostridium perfringens
Correspondence
Diarrhea
Diarrhea - etiology
Enterotoxins
Feces
Female
Food poisoning
Humans
Infectious diseases
Male
Middle Aged
Salmonella food poisoning
Specimens
Toxins
Title Infectious Diarrhea Due to Clostridium perfringens
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