Atherosclerosis and Matrix Metalloproteinases : Experimental Molecular MR Imaging in Vivo

• Published in: Radiology Vol. 251; no. 2; pp. 429 - 438
• Main Authors: AMIRBEKIAN, Vardan, AGUINALDO, Juan Gilberto S, FISHER, Edward A, GALIS, Zorina S, FAYAD, Zahi A, AMIRBEKIAN, Smbat, HYAFIL, Fabien, VUCIC, Esad, SIROL, Marc, WEINREB, David B, LE GRENEUR, Soizic, LANCELOT, Eric, COROT, Claire
• Format: Journal Article
• Language: English
• Published: Oak Brook, IL Radiological Society of North America 01.05.2009
• Subjects: Animals; Atherosclerosis (general aspects, experimental research); Atherosclerosis - diagnosis; Atherosclerosis - metabolism; Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Chelating Agents - pharmacokinetics; Gadolinium - pharmacokinetics; Image Interpretation, Computer-Assisted - methods; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Imaging - methods; Matrix Metalloproteinases - metabolism; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Imaging; Molecular Probe Techniques; Protein Interaction Mapping - methods; Reproducibility of Results; Sensitivity and Specificity; Vascular disease; Molecular imaging; In vivo; Nuclear medicine; Atherosclerosis; Radiology; Medical imagery; Cardiovascular disease; Metalloproteinase; Nuclear magnetic resonance imaging; Functional imaging

To evaluate the capability of P947, a magnetic resonance (MR) imaging contrast agent that molecularly targets matrix metalloproteinases (MMPs), to aid detection and imaging of MMPs in atherosclerotic lesions in vivo; its specificity compared with that of P1135; expression and distribution of MMPs in...