Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses

The inhibition of viral protease is an important target in antiviral drug discovery and development. To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. However, these drugs can have adverse side effec...

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Published inMolecules (Basel, Switzerland) Vol. 25; no. 8; p. 1800
Main Authors Suwannarach, Nakarin, Kumla, Jaturong, Sujarit, Kanaporn, Pattananandecha, Thanawat, Saenjum, Chalermpong, Lumyong, Saisamorn
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 14.04.2020
MDPI
Subjects
antiviral agents
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Antiviral drugs
Biological Products - chemistry
Biological Products - isolation & purification
Biological Products - pharmacology
Coronavirus - drug effects
Coronavirus - enzymology
Coronavirus Infections - drug therapy
Coronavirus Infections - virology
Coronaviruses
COVID-19
Disease transmission
drug discovery
Drugs
Epidemics
FDA approval
fungal metabolites
Fungi
Fungi - chemistry
HIV
Human immunodeficiency virus
Humans
Immunologic Factors - chemistry
Immunologic Factors - isolation & purification
Immunologic Factors - pharmacology
immunomodulatory agents
Infections
Middle East respiratory syndrome
Molecular Structure
Molecular weight
Mortality
natural products
Peptides
Pneumonia
Prevention
Protease Inhibitors - chemistry
Protease Inhibitors - isolation & purification
Protease Inhibitors - pharmacology
Proteins
Respiratory diseases
Review
RNA polymerase
Severe acute respiratory syndrome coronavirus 2
Structure-Activity Relationship
Viral infections
Viruses
China
natural products
coronaviruses
drug discovery
fungal metabolites
immunomodulatory agents
antiviral agents
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Abstract The inhibition of viral protease is an important target in antiviral drug discovery and development. To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. However, these drugs can have adverse side effects and they can become ineffective due to eventual drug resistance. Thus, the search for natural bioactive compounds that were obtained from bio-resources that exert inhibitory capabilities against HIV-1 protease activity is of great interest. Fungi are a source of natural bioactive compounds that offer therapeutic potential in the prevention of viral diseases and for the improvement of human immunomodulation. Here, we made a brief review of the current findings on fungi as producers of protease inhibitors and studies on the relevant candidate fungal bioactive compounds that can offer immunomodulatory activities as potential therapeutic agents of coronaviruses in the future.
AbstractList The inhibition of viral protease is an important target in antiviral drug discovery and development. To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. However, these drugs can have adverse side effects and they can become ineffective due to eventual drug resistance. Thus, the search for natural bioactive compounds that were obtained from bio-resources that exert inhibitory capabilities against HIV-1 protease activity is of great interest. Fungi are a source of natural bioactive compounds that offer therapeutic potential in the prevention of viral diseases and for the improvement of human immunomodulation. Here, we made a brief review of the current findings on fungi as producers of protease inhibitors and studies on the relevant candidate fungal bioactive compounds that can offer immunomodulatory activities as potential therapeutic agents of coronaviruses in the future.
The inhibition of viral protease is an important target in antiviral drug discovery and development. To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. However, these drugs can have adverse side effects and they can become ineffective due to eventual drug resistance. Thus, the search for natural bioactive compounds that were obtained from bio-resources that exert inhibitory capabilities against HIV-1 protease activity is of great interest. Fungi are a source of natural bioactive compounds that offer therapeutic potential in the prevention of viral diseases and for the improvement of human immunomodulation. Here, we made a brief review of the current findings on fungi as producers of protease inhibitors and studies on the relevant candidate fungal bioactive compounds that can offer immunomodulatory activities as potential therapeutic agents of coronaviruses in the future.The inhibition of viral protease is an important target in antiviral drug discovery and development. To date, protease inhibitor drugs, especially HIV-1 protease inhibitors, have been available for human clinical use in the treatment of coronaviruses. However, these drugs can have adverse side effects and they can become ineffective due to eventual drug resistance. Thus, the search for natural bioactive compounds that were obtained from bio-resources that exert inhibitory capabilities against HIV-1 protease activity is of great interest. Fungi are a source of natural bioactive compounds that offer therapeutic potential in the prevention of viral diseases and for the improvement of human immunomodulation. Here, we made a brief review of the current findings on fungi as producers of protease inhibitors and studies on the relevant candidate fungal bioactive compounds that can offer immunomodulatory activities as potential therapeutic agents of coronaviruses in the future.
Author Saenjum, Chalermpong
Suwannarach, Nakarin
Kumla, Jaturong
Sujarit, Kanaporn
Pattananandecha, Thanawat
Lumyong, Saisamorn
AuthorAffiliation 1 Research Center of Microbial Diversity and Sustainable Utilization, Chiang Mai University, Chiang Mai 50200, Thailand; jaturong_yai@hotmail.com (J.K.); kanaporn_s@rmutt.ac.th (K.S.); scboi009@gmail.com (S.L.)
3 Division of Biology, Faculty of Science and Technology, Rajamangala University of Technology Thanyaburi, Thanyaburi, Pathumthani 12110, Thailand
4 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand; thanawat.pdecha@gmail.com (T.P.); chalermpong.saenjum@gmail.com (C.S.)
2 Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
5 Academy of Science, The Royal Society of Thailand, Bangkok 10300, Thailand
AuthorAffiliation_xml – name: 1 Research Center of Microbial Diversity and Sustainable Utilization, Chiang Mai University, Chiang Mai 50200, Thailand; jaturong_yai@hotmail.com (J.K.); kanaporn_s@rmutt.ac.th (K.S.); scboi009@gmail.com (S.L.)
– name: 2 Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
– name: 3 Division of Biology, Faculty of Science and Technology, Rajamangala University of Technology Thanyaburi, Thanyaburi, Pathumthani 12110, Thailand
– name: 4 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand; thanawat.pdecha@gmail.com (T.P.); chalermpong.saenjum@gmail.com (C.S.)
– name: 5 Academy of Science, The Royal Society of Thailand, Bangkok 10300, Thailand
Author_xml – sequence: 1
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  surname: Suwannarach
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  surname: Sujarit
  fullname: Sujarit, Kanaporn
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  givenname: Thanawat
  surname: Pattananandecha
  fullname: Pattananandecha, Thanawat
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  surname: Lumyong
  fullname: Lumyong, Saisamorn
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32295300$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1007/s13225-013-0228-7
10.1248/cpb.57.1076
10.1021/mp500840z
10.1016/j.virol.2013.11.040
10.1016/j.phytochem.2019.112256
10.1039/C3MD00371J
10.1155/MI.2005.63
10.1002/jcb.20153
10.1016/j.phymed.2010.04.010
10.1371/journal.pmed.0030343
10.1016/j.peptides.2006.10.004
10.1007/s10295-003-0101-x
10.1080/14786419.2017.1338286
10.1126/science.8097061
10.1126/scitranslmed.aal3653
10.20944/preprints202002.0438.v1
10.1016/j.tibtech.2013.09.003
10.1016/j.phytol.2017.04.031
10.1007/s00281-017-0629-x
10.7164/antibiotics.50.395
10.1007/s00280-010-1509-4
10.1038/ja.2010.83
10.1038/nrd3053
10.4297/najms.2011.3495
10.1016/S0092-8674(00)81351-3
10.1021/np900279u
10.1039/b208248a
10.1016/S0960-894X(99)00321-2
10.1134/S0003683817010021
10.1001/jama.2020.3072
10.1016/j.antiviral.2007.03.011
10.1016/j.tet.2007.04.062
10.1128/JVI.02114-07
10.1021/ar8000519
10.1016/S0092-8674(00)81350-1
10.1002/elsc.200800019
10.1084/jem.20021890
10.1248/bpb.17.1554
10.1016/j.drudis.2018.09.014
10.1021/np8001139
10.4172/2155-9899.1000537
10.1517/14656560902980202
10.1016/S0378-8741(00)00263-4
10.1136/thorax.2003.012658
10.3389/fmicb.2018.02325
10.1016/j.ijbiomac.2012.09.029
10.1016/j.jmii.2011.09.030
10.1038/nrd2092
10.3390/ijms18071577
10.1016/j.fitote.2016.05.013
10.3109/07388551.2010.543967
10.1007/s00253-002-1076-7
10.1021/jf100914m
10.1006/bbrc.2000.3540
10.1016/j.foodchem.2011.06.029
10.3390/v12020244
10.1038/s41598-018-36411-2
10.1006/cimm.1993.1182
10.1038/s41422-020-0282-0
10.1016/j.tet.2014.10.056
10.1002/ptr.2657
10.1016/S0140-6736(03)13077-2
10.1111/j.1365-2567.2011.03500.x
10.1016/S0022-2836(03)00923-9
10.20944/preprints202002.0242.v1
10.1021/acs.orglett.5b02123
10.1074/jbc.272.14.9204
10.1056/NEJMoa2001316
10.1016/j.jgo.2016.07.008
10.1056/NEJMoa1910993
10.7150/jca.32071
10.2807/ese.18.24.20503-en
10.1089/jmf.2007.0588
10.3748/wjg.v21.i41.11493
10.1021/bi0621415
10.1002/(SICI)1097-0215(19970317)70:6<699::AID-IJC12>3.0.CO;2-5
10.1039/C9FO00733D
10.1016/j.fitote.2014.09.015
10.5772/intechopen.79683
10.1038/s41467-019-13940-6
10.1177/2040206617705500
10.1016/j.antiviral.2014.08.006
10.1021/np000381u
10.1615/IntJMedMushr.v7.i12.130
10.1056/NEJMoa2001017
10.1016/j.phytochem.2013.10.004
10.1186/2008-2231-21-5
10.5812/archcid.13823
10.1016/j.bbrc.2004.04.083
10.1016/j.intimp.2007.01.008
10.1126/science.1085658
10.26434/chemrxiv.11847381
10.1515/znc-2013-9-1003
10.1038/nrg1111
10.3390/v1031209
10.1371/journal.pone.0224740
10.1099/0022-1317-81-4-853
10.1038/nri3133
10.1248/cpb.46.1607
10.1016/j.fct.2015.01.013
10.1016/S0031-9422(98)00254-4
10.1016/j.chembiol.2004.08.011
10.1016/j.virol.2013.04.007
10.1001/jama.289.21.JOC30885
10.1186/s13568-019-0915-1
10.1016/0166-3542(93)90073-R
10.3389/fphar.2019.00115
10.1586/eri.12.11
10.1148/radiol.2020200274
10.20307/nps.2015.21.4.227
10.1186/s12906-019-2766-3
10.1002/ptr.2294
10.1007/s13596-018-0352-8
10.1016/S1567-5769(01)00212-0
10.1021/np300801x
10.1128/CMR.00102-15
10.1134/S0003683815050099
10.1002/mnfr.201900341
10.1111/j.1472-765X.2007.02153.x
10.1021/acs.jafc.6b00539
10.1016/j.mcna.2012.04.002
10.1101/2020.01.29.924100
10.1016/j.tmaid.2019.06.012
10.1007/s12275-008-0127-x
10.1038/s41579-018-0118-9
10.3346/jkms.2020.35.e79
10.3390/md14100190
10.1016/S0140-6736(20)30183-5
10.1042/bj3230557
10.1016/j.jtcme.2019.08.002
10.1080/09540105.2019.1686467
10.1186/1471-2180-13-71
10.3390/biom9090414
10.1002/jsfa.4436
10.1001/jama.290.24.3222
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Keywords natural products
coronaviruses
drug discovery
fungal metabolites
immunomodulatory agents
antiviral agents
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References Song (ref_24) 2020; 295
Ling (ref_80) 2019; 10
ref_93
ref_91
Wang (ref_92) 2014; 99
ref_11
ref_99
Ma (ref_82) 2009; 72
Zhao (ref_68) 2011; 51
Kim (ref_151) 2013; 76
Sonawane (ref_129) 2014; 8
ref_19
Sillapachaiyaporn (ref_85) 2019; 19
ref_16
Machala (ref_8) 2009; 1
Urbani (ref_49) 1997; 272
Su (ref_127) 2020; 173
Fang (ref_35) 2014; 5
Moradali (ref_120) 2007; 7
Chu (ref_95) 1999; 9
Cui (ref_147) 2011; 91
Goetz (ref_9) 2007; 46
Li (ref_138) 2015; 78
Schmutz (ref_90) 2019; 63
Tsantrizos (ref_52) 2008; 41
Wang (ref_18) 2020; 30
ref_23
Puente (ref_43) 2003; 4
Sheahan (ref_14) 2017; 9
ref_21
Meselhy (ref_78) 1998; 49
ref_20
Yang (ref_94) 2016; 14
ref_124
Cui (ref_2) 2018; 17
Yamamoto (ref_42) 2013; 52
Clercq (ref_53) 2016; 29
Ma (ref_126) 2011; 3
Hawas (ref_98) 2012; 11
Su (ref_148) 2013; 21
Zhu (ref_3) 2020; 382
Kumaran (ref_65) 2008; 8
Chu (ref_58) 2004; 59
Cauchemez (ref_1) 2013; 18
Kim (ref_28) 2000; 72
Gallego (ref_88) 2019; 10
Kumar (ref_110) 2012; 45
Ziebuhr (ref_12) 2000; 81
Sato (ref_83) 2009; 57
Guan (ref_25) 2003; 30
Caruso (ref_62) 2000; 50
Guggenheim (ref_115) 2014; 13
Adachi (ref_145) 1994; 17
Li (ref_136) 2014; 34
Chen (ref_63) 2003; 13
Xu (ref_135) 2016; 64
Hsu (ref_139) 1997; 323
Turk (ref_45) 2006; 5
Jia (ref_36) 2015; 21
Sze (ref_130) 2004; 92
Isaka (ref_26) 2007; 63
Anand (ref_51) 2003; 300
Phuong (ref_97) 2009; 23
Wasser (ref_123) 2002; 60
Channappanavar (ref_108) 2017; 39
Hawas (ref_104) 2013; 68
Loutfy (ref_57) 2003; 290
Linnakoski (ref_27) 2018; 9
ref_84
Mielech (ref_13) 2014; 450–451
Paaventhan (ref_134) 2003; 332
Wu (ref_101) 2018; 8
(ref_67) 2010; 63
Vetvicka (ref_122) 2008; 11
Faccin (ref_31) 2007; 45
Wang (ref_142) 1997; 70
Shao (ref_118) 2019; 30
Li (ref_116) 2011; 31
Hsin (ref_140) 2015; 12
Zhao (ref_39) 2017; 20
Hawas (ref_89) 2015; 51
Zhang (ref_32) 2015; 17
Kim (ref_47) 1996; 87
Zapater (ref_114) 2015; 21
Jiang (ref_87) 2011; 18
Tew (ref_73) 2016; 7
Fredenhagen (ref_77) 1997; 50
Dai (ref_96) 2001; 64
Lim (ref_17) 2020; 35
Brik (ref_46) 2003; 1
Xue (ref_50) 2008; 82
ref_59
Kino (ref_141) 1993; 150
Malemud (ref_152) 2018; 9
Ahmed (ref_103) 2017; 53
Murata (ref_149) 2002; 2
Barreiro (ref_7) 2009; 10
Wang (ref_34) 2014; 70
Li (ref_128) 2019; 24
ref_69
ref_64
Kumaran (ref_66) 2009; 47
Momattin (ref_60) 2019; 30
Li (ref_6) 2020; 382
Roy (ref_33) 2017; 25
Razumov (ref_41) 2010; 55
Lull (ref_119) 2005; 2005
Min (ref_79) 1998; 46
Brown (ref_121) 2003; 197
Gao (ref_137) 2019; 2019
Wang (ref_132) 1997; 17
Yeh (ref_143) 2010; 58
Harada (ref_102) 2002; 22
Halawany (ref_81) 2008; 71
ref_117
Priyadarshini (ref_72) 2012; 2
Xu (ref_100) 2019; 10
Enshasy (ref_109) 2013; 31
Gu (ref_30) 2007; 75
Chang (ref_133) 2014; 110
Hobbs (ref_150) 2005; 7
Wang (ref_29) 2000; 276
Wang (ref_86) 2007; 28
Anderson (ref_10) 2009; Vol. 189
Dayer (ref_15) 2017; 12
Kak (ref_112) 2012; 96
Labro (ref_113) 2012; 10
Ryang (ref_74) 2019; 9
Pang (ref_37) 2017; 32
Booth (ref_56) 2003; 289
Jeong (ref_125) 2008; 22
Zhang (ref_105) 2013; 442
Peiris (ref_107) 2003; 361
Mulangu (ref_22) 2019; 381
Yamamoto (ref_55) 2004; 318
Naik (ref_71) 2018; 19
Huang (ref_106) 2020; 395
Blanchard (ref_54) 2004; 11
Drag (ref_44) 2010; 9
Kozarski (ref_144) 2011; 129
Love (ref_48) 1996; 87
Casella (ref_76) 2013; 96
Pohleven (ref_131) 2011; 134
Sarkar (ref_40) 1993; 20
Strobel (ref_61) 1993; 260
Heinig (ref_70) 2013; 60
Seo (ref_146) 2019; 2019
Zhang (ref_38) 2016; 112
Lee (ref_111) 2012; 12
ref_5
ref_4
Mary (ref_75) 2011; 68
References_xml – volume: 60
  start-page: 161
  year: 2013
  ident: ref_70
  article-title: Getting to the bottom of Taxol biosynthesis by fungi
  publication-title: Fungal Divers.
  doi: 10.1007/s13225-013-0228-7
– volume: 57
  start-page: 1076
  year: 2009
  ident: ref_83
  article-title: Anti-human immunodeficiency virus-1 protease activity of new lanostane-type triterpenoids from Ganoderma sinense
  publication-title: Chem. Pharm. Bull.
  doi: 10.1248/cpb.57.1076
– volume: 12
  start-page: 1534
  year: 2015
  ident: ref_140
  article-title: GMI, an immunomodulatory protein from Ganoderma microsporum, potentiates cisplatin-induced apoptosis via autophagy in lung cancer cells
  publication-title: Mol. Pharm.
  doi: 10.1021/mp500840z
– volume: 450–451
  start-page: 64
  year: 2014
  ident: ref_13
  article-title: MERS-CoV papain-like protease has delSGylating and deubiquitinating activities
  publication-title: Virology
  doi: 10.1016/j.virol.2013.11.040
– volume: 173
  start-page: 112256
  year: 2020
  ident: ref_127
  article-title: Lanostane triterpenoids with anti-inflammatory activities from Ganoderma lucidum
  publication-title: Phytochemistry
  doi: 10.1016/j.phytochem.2019.112256
– volume: 5
  start-page: 701
  year: 2014
  ident: ref_35
  article-title: Cytotoxic and antiviral nitrobenzyl sesquiterpenoids from the marine-derived fungus Aspergillus ochraceus Jcma1F17
  publication-title: Med. Chem. Communn.
  doi: 10.1039/C3MD00371J
– volume: 50
  start-page: 3
  year: 2000
  ident: ref_62
  article-title: Isolation of endophytic fungi and actinomycetes taxane producers
  publication-title: Ann. Microbiol.
– volume: 2005
  start-page: 63
  year: 2005
  ident: ref_119
  article-title: Antiinflammatory and immunomodulating properties of fungal metabolites
  publication-title: Mediat. Inflamm.
  doi: 10.1155/MI.2005.63
– volume: 92
  start-page: 1193
  year: 2004
  ident: ref_130
  article-title: Volvariella volvacea lectin activates mouse T lymphocytes by a calcium dependent pathway
  publication-title: J. Cell. Biochem.
  doi: 10.1002/jcb.20153
– volume: 18
  start-page: 189
  year: 2011
  ident: ref_87
  article-title: Isolation of adenosine, iso-sinensetin and dimethylguanosine with antioxidant and HIV-1 protease inhibiting activities from fruiting bodies of Cordyceps militaris
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2010.04.010
– ident: ref_59
  doi: 10.1371/journal.pmed.0030343
– volume: 28
  start-page: 560
  year: 2007
  ident: ref_86
  article-title: A peptide with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Russula paludosa
  publication-title: Peptides
  doi: 10.1016/j.peptides.2006.10.004
– volume: 30
  start-page: 721
  year: 2003
  ident: ref_25
  article-title: Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites
  publication-title: J. Ind. Microbiol. Biotechnol.
  doi: 10.1007/s10295-003-0101-x
– volume: 32
  start-page: 105
  year: 2017
  ident: ref_37
  article-title: Three new polyketides from the marine sponge-derived fungus Trichoderma sp. SCSIO41004
  publication-title: Nat. Prod. Res.
  doi: 10.1080/14786419.2017.1338286
– volume: 260
  start-page: 214
  year: 1993
  ident: ref_61
  article-title: Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew
  publication-title: Science
  doi: 10.1126/science.8097061
– volume: 9
  start-page: 3653
  year: 2017
  ident: ref_14
  article-title: Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aal3653
– ident: ref_11
  doi: 10.20944/preprints202002.0438.v1
– volume: 31
  start-page: 668
  year: 2013
  ident: ref_109
  article-title: Mushroom immunomodulators: unique molecules with unlimited applications
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2013.09.003
– volume: 20
  start-page: 289
  year: 2017
  ident: ref_39
  article-title: Stachybotrysams A–E, prenylated isoindolinone derivatives with anti-HIV activity from the fungus Stachybotrys chartarum
  publication-title: Phytochem. Lett.
  doi: 10.1016/j.phytol.2017.04.031
– volume: 39
  start-page: 529
  year: 2017
  ident: ref_108
  article-title: Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology
  publication-title: Semin. Immunopathol.
  doi: 10.1007/s00281-017-0629-x
– volume: 50
  start-page: 395
  year: 1997
  ident: ref_77
  article-title: Semicochiodinol A and B: inhibitors of HIV-1 protease and EGF-R protein tyrosine kinase related to asterriquinones produced by the fungus Chrysosporium merdarium
  publication-title: J. Antibiot.
  doi: 10.7164/antibiotics.50.395
– volume: 68
  start-page: 827
  year: 2011
  ident: ref_75
  article-title: Pilot study evaluating the interaction between paclitaxel and protease inhibitors in patients with human immunodeficiency virus-associated kaposi’s sarcoma: An eastern cooperative oncology group (ECOG) and AIDS malignancy consortium (AMC) trial
  publication-title: Cancer Chemther. Pharmacol.
  doi: 10.1007/s00280-010-1509-4
– volume: 63
  start-page: 460
  year: 2010
  ident: ref_67
  article-title: Microbial paclitaxel: advances and perspectives
  publication-title: J. Antibiot.
  doi: 10.1038/ja.2010.83
– volume: 9
  start-page: 690
  year: 2010
  ident: ref_44
  article-title: Emerging principles in protease-based drug discovery
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd3053
– volume: 3
  start-page: 495
  year: 2011
  ident: ref_126
  article-title: Triterpenoids from the spores of Ganoderma lucidum
  publication-title: North. Am. J. Med. Sci.
  doi: 10.4297/najms.2011.3495
– volume: 87
  start-page: 343
  year: 1996
  ident: ref_47
  article-title: Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81351-3
– volume: 72
  start-page: 2019
  year: 2009
  ident: ref_82
  article-title: Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese Mushroom Ganoderma colossum
  publication-title: J. Nat. Prod.
  doi: 10.1021/np900279u
– volume: 1
  start-page: 5
  year: 2003
  ident: ref_46
  article-title: HIV-1 protease: Mechanism and drug discovery
  publication-title: Org. Biomol. Chem.
  doi: 10.1039/b208248a
– volume: 9
  start-page: 1949
  year: 1999
  ident: ref_95
  article-title: Isolation and structure (HCV) NS3 protease inhibitor from the fungus Penicillum griseofulvum
  publication-title: Bioorg. Med. Chem. Lett.
  doi: 10.1016/S0960-894X(99)00321-2
– volume: 53
  start-page: 101
  year: 2017
  ident: ref_103
  article-title: Anti-HCV protease of diketopiperazines produced by the red sea sponge-saaociated fungus Aspergillus versicolor
  publication-title: Appl. Biochem. Microbiol.
  doi: 10.1134/S0003683817010021
– ident: ref_21
  doi: 10.1001/jama.2020.3072
– volume: 75
  start-page: 250
  year: 2007
  ident: ref_30
  article-title: Isolation, identification and function of a novel anti-HSV-1 protein from Grifola frondosa
  publication-title: Antivir. Res.
  doi: 10.1016/j.antiviral.2007.03.011
– volume: 13
  start-page: 10
  year: 2003
  ident: ref_63
  article-title: Screening endophytic fungus to produce taxol from Taxus yunnanensis
  publication-title: Biotechnology
– volume: 63
  start-page: 6855
  year: 2007
  ident: ref_26
  article-title: Antiplasmodial and antiviral cyclohexadepsipeptides from the endophytic fungus Pullularia sp. BCC 8613
  publication-title: Tetrahedron
  doi: 10.1016/j.tet.2007.04.062
– volume: 82
  start-page: 2515
  year: 2008
  ident: ref_50
  article-title: Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design
  publication-title: J. Virol.
  doi: 10.1128/JVI.02114-07
– volume: 41
  start-page: 1252
  year: 2008
  ident: ref_52
  article-title: Peptidomimetic therapeutic agents targeting the protease enzyme of the human immunodeficiency virus and hepatitis C virus
  publication-title: Acc. Chem. Res.
  doi: 10.1021/ar8000519
– volume: 87
  start-page: 331
  year: 1996
  ident: ref_48
  article-title: The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81350-1
– volume: 8
  start-page: 438
  year: 2008
  ident: ref_65
  article-title: Production of Taxol from Phyllosticta spinarum, an endophytic fungus of Cupressus sp
  publication-title: Eng. Life Sci.
  doi: 10.1002/elsc.200800019
– volume: 197
  start-page: 1119
  year: 2003
  ident: ref_121
  article-title: Dectin-1 mediates the biological effects of β-glucans
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20021890
– volume: 8
  start-page: 969
  year: 2014
  ident: ref_129
  article-title: Pharmaceutical metabolites with potent bioactivity from mushrooms
  publication-title: J. Phar. Res.
– volume: 17
  start-page: 1554
  year: 1994
  ident: ref_145
  article-title: Enhancement of cytokine production by macrophages stimulated with (l→3)-β-D-glucan, grifolan (GRN), isolated from Grifola frondosa
  publication-title: Biologic. Pharma. Bul.
  doi: 10.1248/bpb.17.1554
– volume: 24
  start-page: 307
  year: 2019
  ident: ref_128
  article-title: Fungal immunomodulatory proteins: characteristic, potential antitumor activities and their molecular mechanisms
  publication-title: Drug Discov. Today
  doi: 10.1016/j.drudis.2018.09.014
– volume: 71
  start-page: 1022
  year: 2008
  ident: ref_81
  article-title: Anti-HIV1- protease activity of lanostane triterpenes from the Vienamese mushroom Ganoderma colossum
  publication-title: J. Nat. Prod.
  doi: 10.1021/np8001139
– volume: 9
  start-page: 1
  year: 2018
  ident: ref_152
  article-title: Immunomodulators in autoimmunity and viral infections
  publication-title: J. Clin. Cell. Immunol.
  doi: 10.4172/2155-9899.1000537
– volume: 10
  start-page: 1615
  year: 2009
  ident: ref_7
  article-title: HIV Protease inhibitors: recent clinical trials and recommendations on use
  publication-title: Expert Opin. Pharmacother.
  doi: 10.1517/14656560902980202
– volume: 72
  start-page: 451
  year: 2000
  ident: ref_28
  article-title: Antiherpetic activities of acidic protein bound polysacchride isolated from Ganoderma lucidum alone and in combinations with interferons
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/S0378-8741(00)00263-4
– volume: 59
  start-page: 252
  year: 2004
  ident: ref_58
  article-title: Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings
  publication-title: Thorax
  doi: 10.1136/thorax.2003.012658
– volume: 9
  start-page: 2325
  year: 2018
  ident: ref_27
  article-title: Antiviral agents from fungi: diversity, mechanisms and potential applications
  publication-title: Front. Microbiol.
  doi: 10.3389/fmicb.2018.02325
– volume: 52
  start-page: 9
  year: 2013
  ident: ref_42
  article-title: Antiherpetic activity of an Agaricus brasiliensis polysaccharide, its sulfated derivative and fractions
  publication-title: Int. J. Boil. Macromol.
  doi: 10.1016/j.ijbiomac.2012.09.029
– volume: 45
  start-page: 165
  year: 2012
  ident: ref_110
  article-title: A review of immunomodulators in the Indian traditional health care system
  publication-title: J. Microbiol. Immunol. Infect.
  doi: 10.1016/j.jmii.2011.09.030
– volume: 5
  start-page: 785
  year: 2006
  ident: ref_45
  article-title: Targeting proteases: Successes, failures and future prospects
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd2092
– ident: ref_91
  doi: 10.3390/ijms18071577
– volume: 112
  start-page: 85
  year: 2016
  ident: ref_38
  article-title: Antiviral anthraquinones and azaphilones produced by an endophytic fungus Nigrospora sp. from Aconitum carmichaeli
  publication-title: Fitoterapia
  doi: 10.1016/j.fitote.2016.05.013
– volume: 22
  start-page: 2587
  year: 2002
  ident: ref_102
  article-title: Antitumer activity of palmitic acid found as a selective cytotoxic substance in a marine red alga
  publication-title: Anticancer Res.
– volume: 31
  start-page: 365
  year: 2011
  ident: ref_116
  article-title: Recent status and prospects of the fungal immunomodulatory protein family
  publication-title: Crit. Rev. Biotechnol.
  doi: 10.3109/07388551.2010.543967
– volume: 60
  start-page: 258
  year: 2002
  ident: ref_123
  article-title: Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides
  publication-title: Appl. Microbiol. Biotechnol.
  doi: 10.1007/s00253-002-1076-7
– volume: 58
  start-page: 8535
  year: 2010
  ident: ref_143
  article-title: Polysaccharides PS-G and protein LZ-8 from Reishi (Ganoderma lucidum) exhibit diverse functions in regulating murine aacrophages and T lymphocytes
  publication-title: Agric. Food Chem.
  doi: 10.1021/jf100914m
– volume: 276
  start-page: 587
  year: 2000
  ident: ref_29
  article-title: Isolation of a novel ubiquitin-like protein from Pleurotus ostreatus mushroom with anti-human immunodeficiency virus, translation-inhibitory, and ribonuclease activities
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.2000.3540
– volume: 11
  start-page: 124
  year: 2012
  ident: ref_98
  article-title: In-vitro bioassays on the metabolites of the fungus Emericella nidulans isolated from the Egyptian red sea algae
  publication-title: Egypt. Pharmaceut. J.
– volume: 129
  start-page: 1667
  year: 2011
  ident: ref_144
  article-title: Antioxidative and immunomodulating activities of polysaccharide extracts of the medicinal mushrooms Agaricus bisporus, Agaricus brasiliensis, Ganoderma lucidum and Phellinus linteus
  publication-title: Food Chem.
  doi: 10.1016/j.foodchem.2011.06.029
– ident: ref_4
  doi: 10.3390/v12020244
– volume: 8
  start-page: 17956
  year: 2018
  ident: ref_101
  article-title: Ergosterol peroxide from marine fungus Phoma sp. induces ROS-dependent apoptosis and autophagy in human lung adenocarcinoma cells
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-36411-2
– volume: 150
  start-page: 101
  year: 1993
  ident: ref_141
  article-title: Ling Zhi-8: A novel T cell mitogen induces cytokine production and upregulation of ICAM-1 expression
  publication-title: Cell. Immunol.
  doi: 10.1006/cimm.1993.1182
– volume: 30
  start-page: 269
  year: 2020
  ident: ref_18
  article-title: Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro
  publication-title: Cell Res.
  doi: 10.1038/s41422-020-0282-0
– volume: 70
  start-page: 9695
  year: 2014
  ident: ref_34
  article-title: Eight new polyketide metabolites from the fungus Pestalotiopsis vaccinii endogenous with the mangrove plant Kandelia candel (L.) Druce
  publication-title: Tetrahedron
  doi: 10.1016/j.tet.2014.10.056
– volume: 23
  start-page: 582
  year: 2009
  ident: ref_97
  article-title: Inhibitory effects of antrodins A-E from Antrodia cinnamomea and their metabolites on hepatitis C virus protease
  publication-title: Phytother. Res.
  doi: 10.1002/ptr.2657
– volume: 361
  start-page: 1319
  year: 2003
  ident: ref_107
  article-title: Coronavirus as a possible cause of severe acute respiratory syndrome
  publication-title: Lancet
  doi: 10.1016/S0140-6736(03)13077-2
– volume: 134
  start-page: 409
  year: 2011
  ident: ref_131
  article-title: CNL, a ricin B-like lectin from mushroom Clitocybe nebularis, induces maturation and activation of dendritic cells via the toll-like receptor 4 pathway
  publication-title: Immunol.
  doi: 10.1111/j.1365-2567.2011.03500.x
– volume: 332
  start-page: 461
  year: 2003
  ident: ref_134
  article-title: A 1.7A structure of Fve, a member of the new fungal immunomodulatory protein family
  publication-title: J. Mol. Boil.
  doi: 10.1016/S0022-2836(03)00923-9
– ident: ref_19
  doi: 10.20944/preprints202002.0242.v1
– volume: 17
  start-page: 4304
  year: 2015
  ident: ref_32
  article-title: Pericoannosin A, a Polyketide synthase–nonribosomal peptide synthetase hybrid metabolite with new carbon skeleton from the endophytic fungus Periconia sp
  publication-title: Org. Lett.
  doi: 10.1021/acs.orglett.5b02123
– volume: 272
  start-page: 9204
  year: 1997
  ident: ref_49
  article-title: Substrate specificity of the hepatitis C virus serine protease NS3
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.272.14.9204
– volume: 2
  start-page: 7
  year: 2012
  ident: ref_72
  article-title: Paclitaxel Against Cancer: A Short Review
  publication-title: Med. Chem.
– ident: ref_64
– volume: 382
  start-page: 1199
  year: 2020
  ident: ref_6
  article-title: Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia
  publication-title: New Engl. J. Med.
  doi: 10.1056/NEJMoa2001316
– volume: 7
  start-page: 354
  year: 2016
  ident: ref_73
  article-title: Ovarian cancer in the older woman
  publication-title: J. Geriatr. Oncol.
  doi: 10.1016/j.jgo.2016.07.008
– volume: 13
  start-page: 32
  year: 2014
  ident: ref_115
  article-title: Immune modulation from five major Mushrooms: application to integrative oncology
  publication-title: Integr. Med. (Encinitas, Calif.)
– volume: 381
  start-page: 2293
  year: 2019
  ident: ref_22
  article-title: A randomized, controlled trial of ebola virus disease therapeutics
  publication-title: New Engl. J. Med.
  doi: 10.1056/NEJMoa1910993
– volume: 10
  start-page: 2415
  year: 2019
  ident: ref_100
  article-title: Cordycepin induces apoptosis and G2/M phase arrest through the ERK pathways in esophageal cancer cells
  publication-title: J. Cancer
  doi: 10.7150/jca.32071
– volume: 18
  start-page: 18
  year: 2013
  ident: ref_1
  article-title: Transmission scenarios for middle east respiratory syndrome coronavirus (MERS-CoV) and how to tell them apart
  publication-title: Eurosurveillance
  doi: 10.2807/ese.18.24.20503-en
– volume: 11
  start-page: 615
  year: 2008
  ident: ref_122
  article-title: Immunological effects of yeast- and mushroom-derived β-glucans
  publication-title: J. Med. Food.
  doi: 10.1089/jmf.2007.0588
– volume: 21
  start-page: 11493
  year: 2015
  ident: ref_114
  article-title: Immunomodulating effects of antibiotics used in the prophylaxis of bacterial infections in advanced cirrhosis
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v21.i41.11493
– volume: 46
  start-page: 8744
  year: 2007
  ident: ref_9
  article-title: Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus
  publication-title: Biochemistry
  doi: 10.1021/bi0621415
– volume: 70
  start-page: 699
  year: 1997
  ident: ref_142
  article-title: The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes
  publication-title: Int. J. Cancer.
  doi: 10.1002/(SICI)1097-0215(19970317)70:6<699::AID-IJC12>3.0.CO;2-5
– volume: 10
  start-page: 3758
  year: 2019
  ident: ref_88
  article-title: Water-soluble extracts from edible mushrooms (Agaricus bisporus) as inhibitors of hepatitis C viral replication
  publication-title: Food Funct.
  doi: 10.1039/C9FO00733D
– volume: 99
  start-page: 153
  year: 2014
  ident: ref_92
  article-title: Bioactive metabolites from the endophytic fungus Alternaria alternata
  publication-title: Fitoterapia
  doi: 10.1016/j.fitote.2014.09.015
– ident: ref_124
  doi: 10.5772/intechopen.79683
– ident: ref_5
– ident: ref_23
  doi: 10.1038/s41467-019-13940-6
– volume: 25
  start-page: 20
  year: 2017
  ident: ref_33
  article-title: Potential of small-molecule fungal metabolites in antiviral chemotherapy
  publication-title: Antivir. Chem. Chemother.
  doi: 10.1177/2040206617705500
– volume: 110
  start-page: 124
  year: 2014
  ident: ref_133
  article-title: Alleviation of respiratory syncytial virus replication and inflammation by fungal immunomodulatory protein FIP-fve from Flammulina velutipes
  publication-title: Antivir. Res.
  doi: 10.1016/j.antiviral.2014.08.006
– volume: 64
  start-page: 125
  year: 2001
  ident: ref_96
  article-title: Circumdatin G, a new alkaloid from the fungus Aspergillus ochraceus
  publication-title: J. Nat. Prod.
  doi: 10.1021/np000381u
– volume: 34
  start-page: 2973
  year: 2014
  ident: ref_136
  article-title: FIP-gts potentiate autophagic cell death against cisplatin-resistant urothelial cancer cells
  publication-title: Anticancer. Res.
– volume: 7
  start-page: 127
  year: 2005
  ident: ref_150
  article-title: The chemistry, nutritional value, immunopharmacology, and safety of the traditional food of medicinal split-gill fungus Schizophyllum commune Fr.:Fr. (Schizophyllaceae). A Literature Review. Int
  publication-title: J. Med. Mushrooms
  doi: 10.1615/IntJMedMushr.v7.i12.130
– volume: 382
  start-page: 727
  year: 2020
  ident: ref_3
  article-title: A novel coronavirus from patients with pneumonia in China, 2019
  publication-title: New Engl. J. Med.
  doi: 10.1056/NEJMoa2001017
– volume: 96
  start-page: 370
  year: 2013
  ident: ref_76
  article-title: Antimicrobial and cytotoxic secondary metabolites from tropical leaf endophytes: Isolation of antibacterial agent pyrrocidine C from Lewia infectoria SNB-GTC2402
  publication-title: Phytochemisty
  doi: 10.1016/j.phytochem.2013.10.004
– volume: 21
  start-page: 5
  year: 2013
  ident: ref_148
  article-title: Isolation and characterization of exopolysaccharide with immunomodulatory activity from fermentation broth of Morchella conica
  publication-title: Daru J. Pharm. Sci.
  doi: 10.1186/2008-2231-21-5
– volume: 12
  start-page: 13823
  year: 2017
  ident: ref_15
  article-title: Lopinavir; A potent drug against coronavirus infection: insight from molecular docking study
  publication-title: Arch. Clin. Infect. Dis.
  doi: 10.5812/archcid.13823
– volume: 51
  start-page: 923
  year: 2011
  ident: ref_68
  article-title: Screening of high taxol producing fungi by mutagenesis and construction of subtracted cDNA library by Suppression substracted hybridization for differentially expressed genes
  publication-title: Acta. Microbiol. Sin.
– volume: 318
  start-page: 719
  year: 2004
  ident: ref_55
  article-title: HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2004.04.083
– volume: 7
  start-page: 701
  year: 2007
  ident: ref_120
  article-title: Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi)
  publication-title: Int. Immunopharmacol.
  doi: 10.1016/j.intimp.2007.01.008
– volume: 300
  start-page: 1763
  year: 2003
  ident: ref_51
  article-title: Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs
  publication-title: Science
  doi: 10.1126/science.1085658
– volume: 2019
  start-page: 1
  year: 2019
  ident: ref_137
  article-title: Protective function of novel fungal immunomodulatory proteins Fip-lti1 and Fip-lti2 from Lentinus tigrinus in concanavalin A induced liver oxidative injury
  publication-title: Oxidative Med. Cell. Longev.
– ident: ref_20
  doi: 10.26434/chemrxiv.11847381
– volume: 68
  start-page: 355
  year: 2013
  ident: ref_104
  article-title: Hepatitis C Virus NS3-NS4A protease inhibitors from the endophytic Penicillium chrysogenum isolated from the red alga Liagora viscida
  publication-title: Z. Für Nat. C
  doi: 10.1515/znc-2013-9-1003
– volume: 4
  start-page: 544
  year: 2003
  ident: ref_43
  article-title: Human and mouse proteases: A comparative genomic approach
  publication-title: Nat. Rev.
  doi: 10.1038/nrg1111
– volume: 1
  start-page: 1209
  year: 2009
  ident: ref_8
  article-title: Current and novel inhibitors of HIV protease
  publication-title: Viruses
  doi: 10.3390/v1031209
– ident: ref_117
  doi: 10.1371/journal.pone.0224740
– volume: 81
  start-page: 853
  year: 2000
  ident: ref_12
  article-title: Virus-encoded proteinases and proteolytic processing in the Nidovirales
  publication-title: J. Gen. Virol.
  doi: 10.1099/0022-1317-81-4-853
– volume: 12
  start-page: 125
  year: 2012
  ident: ref_111
  article-title: Immunomodulatory functions of type I interferons
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri3133
– volume: 55
  start-page: 14
  year: 2010
  ident: ref_41
  article-title: Antiviral activity of aqueous extracts and polysaccharide fractions from mycelium and fruit bodies of higher fungi
  publication-title: Antibiot. chemoterapy
– volume: 46
  start-page: 1607
  year: 1998
  ident: ref_79
  article-title: Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease
  publication-title: Chem. Pharm. Bull.
  doi: 10.1248/cpb.46.1607
– volume: 78
  start-page: 64
  year: 2015
  ident: ref_138
  article-title: Identification and functional characterization of a novel fungal immunomodulatory protein from Postia placenta
  publication-title: Food Chem. Toxicol.
  doi: 10.1016/j.fct.2015.01.013
– volume: 49
  start-page: 1651
  year: 1998
  ident: ref_78
  article-title: Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum
  publication-title: Phytochemistry
  doi: 10.1016/S0031-9422(98)00254-4
– volume: 11
  start-page: 1445
  year: 2004
  ident: ref_54
  article-title: High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase
  publication-title: Chem. Boil.
  doi: 10.1016/j.chembiol.2004.08.011
– volume: 442
  start-page: 156
  year: 2013
  ident: ref_105
  article-title: Porcine reproductive and respiratory syndrome virus activates inflammasomes of porcine alveolar macrophages via its small envelope protein E
  publication-title: Virology
  doi: 10.1016/j.virol.2013.04.007
– volume: 289
  start-page: 2801
  year: 2003
  ident: ref_56
  article-title: Clinical features and short-term outcomes of 144 patients with SARS in the greater toronto area
  publication-title: JAMA
  doi: 10.1001/jama.289.21.JOC30885
– volume: 9
  start-page: 1
  year: 2019
  ident: ref_74
  article-title: Anti-HIV, antitumor and immunomodulatory activities of paclitaxel from fermentation broth using molecular imprinting technique
  publication-title: Amb Express
  doi: 10.1186/s13568-019-0915-1
– volume: 20
  start-page: 293
  year: 1993
  ident: ref_40
  article-title: Antiviral effect of the extract of culture medium of Lentinus edodes mycelia on the replication of herpex simplex virus type I
  publication-title: Antiviral Res.
  doi: 10.1016/0166-3542(93)90073-R
– volume: 10
  start-page: 115
  year: 2019
  ident: ref_80
  article-title: Identification of biologically Active Ganoderma lucidum compounds and synthesis of improved derivatives That confer anti-cancer activities in vitro
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2019.00115
– volume: 10
  start-page: 319
  year: 2012
  ident: ref_113
  article-title: Immunomodulatory effects of antimicrobial agents. Part I: antibacterial and antiviral agents
  publication-title: Expert Rev. Anti-Infect. Ther.
  doi: 10.1586/eri.12.11
– volume: 295
  start-page: 210
  year: 2020
  ident: ref_24
  article-title: Emerging 2019 novel coronavirus (2019-nCoV) pneumonia
  publication-title: Radiology
  doi: 10.1148/radiol.2020200274
– volume: 21
  start-page: 227
  year: 2015
  ident: ref_36
  article-title: Pestalotiolide A, a new antiviral phthalide derivative from a soft coral-derived fungus Pestalotiopsis sp
  publication-title: Nat. Prod. Sci.
  doi: 10.20307/nps.2015.21.4.227
– volume: 19
  start-page: 1
  year: 2019
  ident: ref_85
  article-title: Anti-HIV-1 protease activity of the crude extracts and isolated compounds from Auricularia polytricha
  publication-title: Bmc Complement. Altern. Med.
  doi: 10.1186/s12906-019-2766-3
– volume: 22
  start-page: 614
  year: 2008
  ident: ref_125
  article-title: Ganoderma applanatum: a promising mushroom for antitumor and immunomodulating activity
  publication-title: Phytother. Res.
  doi: 10.1002/ptr.2294
– volume: 19
  start-page: 1
  year: 2018
  ident: ref_71
  article-title: Developments in taxol production through endophytic fungal biotechnology: a review
  publication-title: Orient. Pharm. Exp. Med.
  doi: 10.1007/s13596-018-0352-8
– volume: 14
  start-page: 299
  year: 2016
  ident: ref_94
  article-title: H1-A, a compound isolated from Fusarium oxysporum inhibits hepatitis C virus (HCV) NS3 serine protease
  publication-title: Chin. J. Nat. Med.
– volume: 2
  start-page: 673
  year: 2002
  ident: ref_149
  article-title: The skewing to Th1 induced by lentinan is directed through the distinctive cytokine production by macrophages with elevated intracellular glutathione content
  publication-title: Int. Immunopharmacol.
  doi: 10.1016/S1567-5769(01)00212-0
– volume: 76
  start-page: 845
  year: 2013
  ident: ref_151
  article-title: Lanostane triterpenoids from the mushroom Naematoloma fasciculare
  publication-title: J. Nat. Prod.
  doi: 10.1021/np300801x
– volume: 29
  start-page: 695
  year: 2016
  ident: ref_53
  article-title: Approved antiviral drugs over the past 50 years
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.00102-15
– volume: 51
  start-page: 579
  year: 2015
  ident: ref_89
  article-title: Alternariol derivatives from Alternaria alternata, an endophytic fungi residing in red sea soft coral, inhibit HCV NS3/4A protease
  publication-title: Appl. Biochem. Microbiol.
  doi: 10.1134/S0003683815050099
– volume: 63
  start-page: 1900341
  year: 2019
  ident: ref_90
  article-title: The Alternaria mycotoxin alternariol triggers the immune response of IL-1β-stimulated, differentiated Caco-2 cells
  publication-title: Mol. Nutr. Food Res.
  doi: 10.1002/mnfr.201900341
– volume: 45
  start-page: 24
  year: 2007
  ident: ref_31
  article-title: Antiviral activity of aqueous and ethanol extracts and of an isolated polysaccharide from Agaricus brasiliensis against poliovirus type 1
  publication-title: Lett. Appl. Microbiol.
  doi: 10.1111/j.1472-765X.2007.02153.x
– volume: 64
  start-page: 2690
  year: 2016
  ident: ref_135
  article-title: Recombinant FIP-gat, a fungal immunomodulatory protein from Ganoderma atrum, induces growth inhibition and cell death in breast cancer cells
  publication-title: J. Agric. Food Chem.
  doi: 10.1021/acs.jafc.6b00539
– volume: 2019
  start-page: 1
  year: 2019
  ident: ref_146
  article-title: Structural elucidation and immune-enhancing effects of novel polysaccharide from Grifola frondosa
  publication-title: Biomed. Res. Int.
– volume: 96
  start-page: 455
  year: 2012
  ident: ref_112
  article-title: Immunotherapies in infectious diseases
  publication-title: Med. Clin. North. Am.
  doi: 10.1016/j.mcna.2012.04.002
– ident: ref_16
  doi: 10.1101/2020.01.29.924100
– volume: 30
  start-page: 9
  year: 2019
  ident: ref_60
  article-title: A systemtic review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronaavirus (MERS-CoV)
  publication-title: Travel. Med. Infect. Dis.
  doi: 10.1016/j.tmaid.2019.06.012
– volume: 47
  start-page: 40
  year: 2009
  ident: ref_66
  article-title: Isolation and identification of an anticancer drug, taxol from Phyllosticta tabernaemontanae, a leaf spot fungus of an angiosperm, Wrightia tinctoria
  publication-title: J. Microbiol.
  doi: 10.1007/s12275-008-0127-x
– volume: 17
  start-page: 181
  year: 2018
  ident: ref_2
  article-title: Origin and evolution of pathogenic coronaviruses
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/s41579-018-0118-9
– volume: 35
  start-page: 79
  year: 2020
  ident: ref_17
  article-title: Case of the index patient who caused tertiary transmission of coronavirus disease 2019 in Korea: the application of lopinavir/ritonavir for the treatment of COVID-19 pneumonia monitored by quantitative RT-PCR
  publication-title: J. Korean Med. Sci.
  doi: 10.3346/jkms.2020.35.e79
– ident: ref_93
  doi: 10.3390/md14100190
– volume: 395
  start-page: 497
  year: 2020
  ident: ref_106
  article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30183-5
– volume: 323
  start-page: 557
  year: 1997
  ident: ref_139
  article-title: Fip-vvo, a new fungal immunomodulatory protein isolated from Volvariella volvacea
  publication-title: Biochem. J.
  doi: 10.1042/bj3230557
– volume: Vol. 189
  start-page: 85
  year: 2009
  ident: ref_10
  article-title: Viral Protease Inhibitors
  publication-title: Pharmacology and Therapeutics of Cough
– ident: ref_84
  doi: 10.1016/j.jtcme.2019.08.002
– volume: 30
  start-page: 1253
  year: 2019
  ident: ref_118
  article-title: Characterization of a novel fungal immunomodulatory protein, FIP-SJ75 shuffled from Ganoderma lucidum, Flammulina velutipes and Volvariella volvacea
  publication-title: Food Agric. Immunol.
  doi: 10.1080/09540105.2019.1686467
– ident: ref_69
  doi: 10.1186/1471-2180-13-71
– ident: ref_99
  doi: 10.3390/biom9090414
– volume: 91
  start-page: 2180
  year: 2011
  ident: ref_147
  article-title: Isolation, partial characterisation and immunomodulatory activities of polysaccharide from Morchella esculenta
  publication-title: J. Sci. Food Agric.
  doi: 10.1002/jsfa.4436
– volume: 290
  start-page: 3222
  year: 2003
  ident: ref_57
  article-title: Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome
  publication-title: JAMA
  doi: 10.1001/jama.290.24.3222
– volume: 17
  start-page: 419
  year: 1997
  ident: ref_132
  article-title: Action of lectin from the mushroom Trichoderma mongolicum on macrophages, splenocytes and life-span in sarcoma-bearing mice
  publication-title: Anticancer Res.
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Snippet The inhibition of viral protease is an important target in antiviral drug discovery and development. To date, protease inhibitor drugs, especially HIV-1...
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SubjectTerms antiviral agents
Antiviral Agents - chemistry
Antiviral Agents - pharmacology
Antiviral drugs
Biological Products - chemistry
Biological Products - isolation & purification
Biological Products - pharmacology
Coronavirus - drug effects
Coronavirus - enzymology
Coronavirus Infections - drug therapy
Coronavirus Infections - virology
Coronaviruses
COVID-19
Disease transmission
drug discovery
Drugs
Epidemics
FDA approval
fungal metabolites
Fungi
Fungi - chemistry
HIV
Human immunodeficiency virus
Humans
Immunologic Factors - chemistry
Immunologic Factors - isolation & purification
Immunologic Factors - pharmacology
immunomodulatory agents
Infections
Middle East respiratory syndrome
Molecular Structure
Molecular weight
Mortality
natural products
Peptides
Pneumonia
Prevention
Protease Inhibitors - chemistry
Protease Inhibitors - isolation & purification
Protease Inhibitors - pharmacology
Proteins
Respiratory diseases
Review
RNA polymerase
Severe acute respiratory syndrome coronavirus 2
Structure-Activity Relationship
Viral infections
Viruses
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  priority: 102
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Title Natural Bioactive Compounds from Fungi as Potential Candidates for Protease Inhibitors and Immunomodulators to Apply for Coronaviruses
URI https://www.ncbi.nlm.nih.gov/pubmed/32295300
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Volume 25
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