The Influence of Heart Rate Variability Biofeedback on Cardiac Regulation and Functional Brain Connectivity

• Published in: Frontiers in neuroscience Vol. 15; p. 691988
• Main Authors: Schumann, Andy, de la Cruz, Feliberto, Köhler, Stefanie, Brotte, Lisa, Bär, Karl-Jürgen
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 29.06.2021; Frontiers Media S.A
• Subjects: Amygdala; autonomic nervous system; Biofeedback; Brain mapping; cingulate cortex; Cortex (cingulate); Emotions; Feedback; Functional magnetic resonance imaging; Heart rate; Hypothalamus; insula; Magnetic resonance imaging; Mental disorders; Nervous system; Neural networks; Neuroimaging; Neuroscience; Pacemakers; Physiology; Prefrontal cortex; resting state functional connectivity; Sensors; Smartphones; Supplementary motor area; Temporal cortex; cingulate cortex; resting state functional connectivity; autonomic nervous system; insula; prefrontal cortex
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2021.691988

Heart rate variability (HRV) biofeedback has a beneficial impact on perceived stress and emotion regulation. However, its impact on brain function is still unclear. In this study, we aimed to investigate the effect of an 8-week HRV-biofeedback intervention on functional brain connectivity in healthy subjects. HRV biofeedback was carried out in five sessions per week, including four at home and one in our lab. A control group played instead of the training. Functional magnetic resonance imaging was conducted before and after the intervention in both groups. To compute resting state functional connectivity (RSFC), we defined regions of interest in the ventral medial prefrontal cortex (VMPFC) and a total of 260 independent anatomical regions for network-based analysis. Changes of RSFC of the VMPFC to other brain regions were compared between groups. Temporal changes of HRV during the resting state recording were correlated to dynamic functional connectivity of the VMPFC. First, we corroborated the role of the VMPFC in cardiac autonomic regulation. We found that temporal changes of HRV were correlated to dynamic changes of prefrontal connectivity, especially to the middle cingulate cortex, the left insula, supplementary motor area, dorsal and ventral lateral prefrontal regions. The biofeedback group showed a drop in heart rate by 5.2 beats/min and an increased SDNN as a measure of HRV by 8.6 ms (18%) after the intervention. Functional connectivity of the VMPFC increased mainly to the insula, the amygdala, the middle cingulate cortex, and lateral prefrontal regions after biofeedback intervention when compared to changes in the control group. Network-based statistic showed that biofeedback had an influence on a broad functional network of brain regions. Our results show that increased heart rate variability induced by HRV-biofeedback is accompanied by changes in functional brain connectivity during resting state.