Concurrent Training Increases Serum Brain-Derived Neurotrophic Factor in Older Adults Regardless of the Exercise Frequency
Human brain function declines with aging. In this sense, exercise-based interventions has a promising effect on brain plasticity for older adults. Serum brain-derived neurotrophic factor (BDNF) is a positive biomarker for brain neuroplasticity in healthy older adults also modified by exercise traini...
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Published in | Frontiers in aging neuroscience Vol. 14; p. 791698 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Abstract | Human brain function declines with aging. In this sense, exercise-based interventions has a promising effect on brain plasticity for older adults. Serum brain-derived neurotrophic factor (BDNF) is a positive biomarker for brain neuroplasticity in healthy older adults also modified by exercise training. Selected features of the exercise prescription for improving brain health are missing; therefore, the aim of this study was to determine the effects of concurrent exercise training frequency on serum BDNF levels in healthy older adults.
Nineteen volunteers (age: 65 ± 4 year; body mass index: 28.0 ± 4.5 kg/m
) completed either a three times/week (3-t/w) (
= 8) or five times/week (5-t/w) (
= 11) concurrent exercise program. The exercise program lasted 11 weeks and all exercise sessions were performed for 50 min at moderate intensity. Serum BDNF, body composition, cardiovascular, and physical fitness variables were assessed before and after the exercise training program.
Regardless of the group, the serum BDNF increased following the intervention (
< 0.001), and there were no significant group (
= 0.827) or interaction (
= 0.063) effects. The maximal oxygen consumption (VO2max) increased regardless of the group (
= 0.007), with a non-significant group (
= 0.722) or interaction (
= 0.223) effects. Upper- and lower-body strength increased in both groups (
= 0.003); however, there was no effect of the training frequency (
= 0.53). For the skeletal muscle mass, there was a trend in the interaction effect (
= 0.053). Finally, the body fat percentage was unchanged.
Eleven weeks of combined exercise training increased serum BDNF levels in healthy older adults, a response independent of the training frequency. The overall fitness level improved similarly in both exercise groups. These data reveal that a minimal dosage of concurrent exercise enhance functional capacity and a brain health biomarker in older adults. |
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AbstractList | Human brain function declines with aging. In this sense, exercise-based interventions has a promising effect on brain plasticity for older adults. Serum brain-derived neurotrophic factor (BDNF) is a positive biomarker for brain neuroplasticity in healthy older adults also modified by exercise training. Selected features of the exercise prescription for improving brain health are missing; therefore, the aim of this study was to determine the effects of concurrent exercise training frequency on serum BDNF levels in healthy older adults.
Nineteen volunteers (age: 65 ± 4 year; body mass index: 28.0 ± 4.5 kg/m
) completed either a three times/week (3-t/w) (
= 8) or five times/week (5-t/w) (
= 11) concurrent exercise program. The exercise program lasted 11 weeks and all exercise sessions were performed for 50 min at moderate intensity. Serum BDNF, body composition, cardiovascular, and physical fitness variables were assessed before and after the exercise training program.
Regardless of the group, the serum BDNF increased following the intervention (
< 0.001), and there were no significant group (
= 0.827) or interaction (
= 0.063) effects. The maximal oxygen consumption (VO2max) increased regardless of the group (
= 0.007), with a non-significant group (
= 0.722) or interaction (
= 0.223) effects. Upper- and lower-body strength increased in both groups (
= 0.003); however, there was no effect of the training frequency (
= 0.53). For the skeletal muscle mass, there was a trend in the interaction effect (
= 0.053). Finally, the body fat percentage was unchanged.
Eleven weeks of combined exercise training increased serum BDNF levels in healthy older adults, a response independent of the training frequency. The overall fitness level improved similarly in both exercise groups. These data reveal that a minimal dosage of concurrent exercise enhance functional capacity and a brain health biomarker in older adults. BackgroundHuman brain function declines with aging. In this sense, exercise-based interventions has a promising effect on brain plasticity for older adults. Serum brain-derived neurotrophic factor (BDNF) is a positive biomarker for brain neuroplasticity in healthy older adults also modified by exercise training. Selected features of the exercise prescription for improving brain health are missing; therefore, the aim of this study was to determine the effects of concurrent exercise training frequency on serum BDNF levels in healthy older adults.MethodsNineteen volunteers (age: 65 ± 4 year; body mass index: 28.0 ± 4.5 kg/m2) completed either a three times/week (3-t/w) (n = 8) or five times/week (5-t/w) (n = 11) concurrent exercise program. The exercise program lasted 11 weeks and all exercise sessions were performed for 50 min at moderate intensity. Serum BDNF, body composition, cardiovascular, and physical fitness variables were assessed before and after the exercise training program.ResultsRegardless of the group, the serum BDNF increased following the intervention (p < 0.001), and there were no significant group (p = 0.827) or interaction (p = 0.063) effects. The maximal oxygen consumption (VO2max) increased regardless of the group (p = 0.007), with a non-significant group (p = 0.722) or interaction (p = 0.223) effects. Upper- and lower-body strength increased in both groups (p = 0.003); however, there was no effect of the training frequency (p = 0.53). For the skeletal muscle mass, there was a trend in the interaction effect (p = 0.053). Finally, the body fat percentage was unchanged.ConclusionEleven weeks of combined exercise training increased serum BDNF levels in healthy older adults, a response independent of the training frequency. The overall fitness level improved similarly in both exercise groups. These data reveal that a minimal dosage of concurrent exercise enhance functional capacity and a brain health biomarker in older adults. Background: Human brain function declines with aging and exercise is considered a non-pharmacological intervention with demonstrated efficacy to delay brain impairment. The serum brain-derived neurotrophic factor (BDNF) is a positive biomarker for brain neuroplasticity in healthy older adults also modified by exercise training. Selected features of the exercise prescription for improving brain health are missing; therefore, the aim of this study was to determine the effects of concurrent exercise training frequency on serum BDNF levels in healthy older adults. Methods: Nineteen volunteers (age: 65 ± 4 yr.; body mass index: 28.0±4.5 kg/m²) completed either a 3 times/week (3-t/w) (n=8) or 5 times/week (5-t/w) (n=11) concurrent exercise program. The exercise program lasted 11 weeks and all exercise sessions were performed for 50 min at moderate intensity. Serum BDNF, body composition, cardiovascular, and physical fitness variables were assessed before and after the exercise training program. Results: Regardless of the group, the serum BDNF increased following the intervention (p<0.001), and there were no significant group (p=0.827) or interaction (p=0.063) effects. The maximal oxygen consumption (VO2max) increased regardless of the group (p=0.007), with a non-significant group (p=0.722) or interaction (p=0.223) effects. Upper- and lower-body strength increased in both groups (p=0.003); however, there was no effect of the training frequency (p=0.53). For the skeletal muscle mass, there was a trend in the interaction effect (p=0.053). Finally, the body fat percentage was unchanged. Conclusions: Eleven weeks of combined exercise training increased serum BDNF levels in healthy older adults, a response independent of the training frequency. The overall fitness level improved similarly in both exercise groups. These data reveal that a minimal dosage of concurrent exercise enhance the functional capacity and brain health in older adults. Background Human brain function declines with aging. In this sense, exercise-based interventions has a promising effect on brain plasticity for older adults. Serum brain-derived neurotrophic factor (BDNF) is a positive biomarker for brain neuroplasticity in healthy older adults also modified by exercise training. Selected features of the exercise prescription for improving brain health are missing; therefore, the aim of this study was to determine the effects of concurrent exercise training frequency on serum BDNF levels in healthy older adults. Methods Nineteen volunteers (age: 65 ± 4 year; body mass index: 28.0 ± 4.5 kg/m 2 ) completed either a three times/week (3-t/w) ( n = 8) or five times/week (5-t/w) ( n = 11) concurrent exercise program. The exercise program lasted 11 weeks and all exercise sessions were performed for 50 min at moderate intensity. Serum BDNF, body composition, cardiovascular, and physical fitness variables were assessed before and after the exercise training program. Results Regardless of the group, the serum BDNF increased following the intervention ( p < 0.001), and there were no significant group ( p = 0.827) or interaction ( p = 0.063) effects. The maximal oxygen consumption (VO2max) increased regardless of the group ( p = 0.007), with a non-significant group ( p = 0.722) or interaction ( p = 0.223) effects. Upper- and lower-body strength increased in both groups ( p = 0.003); however, there was no effect of the training frequency ( p = 0.53). For the skeletal muscle mass, there was a trend in the interaction effect ( p = 0.053). Finally, the body fat percentage was unchanged. Conclusion Eleven weeks of combined exercise training increased serum BDNF levels in healthy older adults, a response independent of the training frequency. The overall fitness level improved similarly in both exercise groups. These data reveal that a minimal dosage of concurrent exercise enhance functional capacity and a brain health biomarker in older adults. |
Author | Lira, Fabio Santos García-Suárez, Patricia C Rentería, Iván Johnson, David K Machado-Parra, Juan Pablo Canton-Martínez, Ermilo Moncada-Jiménez, José Jiménez-Maldonado, Alberto |
AuthorAffiliation | 2 Department of Health, Sports and Exercise Sciences, University of Kansas , Lawrence, KS , United States 4 Exercise and Immunometabolism Research Group, Department of Physical Education, Paulista State University, UNESP , Presidente Prudente , Brazil 3 Human Movement Sciences Research Center (CIMOHU), University of Costa Rica , San Jose , Costa Rica 1 Facultad de Deportes, Universidad Autónoma de Baja California , Ensenada , Mexico 5 Department of Neurology, University of California, Davis , Davis, CA , United States |
AuthorAffiliation_xml | – name: 3 Human Movement Sciences Research Center (CIMOHU), University of Costa Rica , San Jose , Costa Rica – name: 4 Exercise and Immunometabolism Research Group, Department of Physical Education, Paulista State University, UNESP , Presidente Prudente , Brazil – name: 1 Facultad de Deportes, Universidad Autónoma de Baja California , Ensenada , Mexico – name: 2 Department of Health, Sports and Exercise Sciences, University of Kansas , Lawrence, KS , United States – name: 5 Department of Neurology, University of California, Davis , Davis, CA , United States |
Author_xml | – sequence: 1 givenname: Ermilo surname: Canton-Martínez fullname: Canton-Martínez, Ermilo organization: Facultad de Deportes, Universidad Autónoma de Baja California, Ensenada, Mexico – sequence: 2 givenname: Iván surname: Rentería fullname: Rentería, Iván organization: Facultad de Deportes, Universidad Autónoma de Baja California, Ensenada, Mexico – sequence: 3 givenname: Patricia C surname: García-Suárez fullname: García-Suárez, Patricia C organization: Department of Health, Sports and Exercise Sciences, University of Kansas, Lawrence, KS, United States – sequence: 4 givenname: José surname: Moncada-Jiménez fullname: Moncada-Jiménez, José organization: Human Movement Sciences Research Center (CIMOHU), University of Costa Rica, San Jose, Costa Rica – sequence: 5 givenname: Juan Pablo surname: Machado-Parra fullname: Machado-Parra, Juan Pablo organization: Facultad de Deportes, Universidad Autónoma de Baja California, Ensenada, Mexico – sequence: 6 givenname: Fabio Santos surname: Lira fullname: Lira, Fabio Santos organization: Exercise and Immunometabolism Research Group, Department of Physical Education, Paulista State University, UNESP, Presidente Prudente, Brazil – sequence: 7 givenname: David K surname: Johnson fullname: Johnson, David K organization: Department of Neurology, University of California, Davis, Davis, CA, United States – sequence: 8 givenname: Alberto surname: Jiménez-Maldonado fullname: Jiménez-Maldonado, Alberto organization: Facultad de Deportes, Universidad Autónoma de Baja California, Ensenada, Mexico |
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CitedBy_id | crossref_primary_10_3389_fendo_2023_1151184 crossref_primary_10_3390_ijerph191912573 crossref_primary_10_3390_brainsci13060844 crossref_primary_10_3390_brainsci12091142 |
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Copyright | Copyright © 2022 Canton-Martínez, Rentería, García-Suárez, Moncada-Jiménez, Machado-Parra, Lira, Johnson and Jiménez-Maldonado. 2022. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Copyright © 2022 Canton-Martínez, Rentería, García-Suárez, Moncada-Jiménez, Machado-Parra, Lira, Johnson and Jiménez-Maldonado. 2022 Canton-Martínez, Rentería, García-Suárez, Moncada-Jiménez, Machado-Parra, Lira, Johnson and Jiménez-Maldonado |
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Keywords | brain derived neurotrophic factor heart rate concurrent training elderly body fat |
Language | English |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Christina Maria Pabelick, Mayo Clinic, United States Reviewed by: Matea Nikolac Perković, Rudjer Boskovic Institute, Croatia; Tomoyasu Kadoguchi, The University of Tokyo, Japan These authors share first authorship This article was submitted to Neurocognitive Aging and Behavior, a section of the journal Frontiers in Aging Neuroscience |
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Snippet | Human brain function declines with aging. In this sense, exercise-based interventions has a promising effect on brain plasticity for older adults. Serum... Background Human brain function declines with aging. In this sense, exercise-based interventions has a promising effect on brain plasticity for older adults.... Background: Human brain function declines with aging and exercise is considered a non-pharmacological intervention with demonstrated efficacy to delay brain... BackgroundHuman brain function declines with aging. In this sense, exercise-based interventions has a promising effect on brain plasticity for older adults.... |
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SubjectTerms | Aging Aging Neuroscience Blood pressure Body composition Body fat Body mass index Brain-derived neurotrophic factor concurrent training elderly Exercise Fitness training programs Heart rate Manufacturers Musculoskeletal system Neural plasticity Older people Oxygen consumption Physical fitness Physical training Physiology Skeletal muscle Sports training Strength training Walking |
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Title | Concurrent Training Increases Serum Brain-Derived Neurotrophic Factor in Older Adults Regardless of the Exercise Frequency |
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