Rational Design of Artificial Metalloproteins and Metalloenzymes with Metal Clusters

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 15; p. 2743
• Main Author: Lin, Ying-Wu
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.07.2019; MDPI
• Subjects: Aqueous solutions; Binding sites; Cadmium; Carrier Proteins; Catalysis; Catalytic Domain; Chloride; Design; Enzymes; Enzymes - chemistry; Ligands; metalclusters; metalloenzymes; metalloproteins; Metalloproteins - chemistry; Metals - chemistry; Models, Molecular; Molecular Conformation; Molecular Structure; Nanoparticles; Protein Binding; protein design; Protein Engineering; Proteins; Review; Sulfur; Symmetry; synthetic models; Zinc; synthetic models; metalclusters; protein design; metalloproteins; metalloenzymes

Metalloproteins and metalloenzymes play important roles in biological systems by using the limited metal ions, complexes, and clusters that are associated with the protein matrix. The design of artificial metalloproteins and metalloenzymes not only reveals the structure and function relationship of...