Microencapsulation by a Spray Drying Approach to Produce Innovative Probiotics-Based Products Extending the Shelf-Life in Non-Refrigerated Conditions
Recently, there has been a growing interest in producing functional foods containing encapsulated probiotic bacteria due to their positive effects on human health. According to their perceived health benefits, probiotics have been incorporated into a range of dairy products, but the current major ch...
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Published in | Molecules (Basel, Switzerland) Vol. 28; no. 2; p. 860 |
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Abstract | Recently, there has been a growing interest in producing functional foods containing encapsulated probiotic bacteria due to their positive effects on human health. According to their perceived health benefits, probiotics have been incorporated into a range of dairy products, but the current major challenge is to market new, multicomponent probiotic foods and supplements. Nevertheless, only a few products containing encapsulated probiotic cells can be found as non-refrigerated products. In this work, spray drying technology was investigated in order to produce an innovative nutraceutical formulation based on lactic acid bacteria (LAB), and was able to ensure a good storage stability of probiotics (no less than 109 CFU/cps) in non-refrigerated conditions. Probiotic-loaded microparticles from spray drying experiments were produced under different conditions and compared by thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and the enumeration of the number of viable cells in order to identify the formulation exhibiting the most promising characteristics. Results from the dissolution test revealed that the optimized formulation provides a suitable amount of living cells after digestion of microparticles stored for 12 months at room temperature and confirmed that the microencapsulation process by spray drying ensures a good protection of probiotics for nutraceutical purposes. |
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AbstractList | Recently, there has been a growing interest in producing functional foods containing encapsulated probiotic bacteria due to their positive effects on human health. According to their perceived health benefits, probiotics have been incorporated into a range of dairy products, but the current major challenge is to market new, multicomponent probiotic foods and supplements. Nevertheless, only a few products containing encapsulated probiotic cells can be found as non-refrigerated products. In this work, spray drying technology was investigated in order to produce an innovative nutraceutical formulation based on lactic acid bacteria (LAB), and was able to ensure a good storage stability of probiotics (no less than 109 CFU/cps) in non-refrigerated conditions. Probiotic-loaded microparticles from spray drying experiments were produced under different conditions and compared by thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and the enumeration of the number of viable cells in order to identify the formulation exhibiting the most promising characteristics. Results from the dissolution test revealed that the optimized formulation provides a suitable amount of living cells after digestion of microparticles stored for 12 months at room temperature and confirmed that the microencapsulation process by spray drying ensures a good protection of probiotics for nutraceutical purposes. |
Author | Mazzoni, Cristina Gullifa, Giuseppina Papa, Elena Materazzi, Stefano Barone, Laura Risoluti, Roberta Battistini, Alfredo Martin Fraguas, Rodrigo |
AuthorAffiliation | 4 Department of Chemistry, Campus Varginha, University of José do Rosário Vellano—UNIFENAS, Alfenas 37130-000, Brazil 1 Department of Chemistry, “Sapienza” University of Rome, p.le A.Moro 5, 00185 Rome, Italy 3 Consiglio per la Ricerca in Agricoltura e l’Analisi dell’economia Agraria—Centro di Politiche e Bioeconomia, Via Pò 14, 00198 Rome, Italy 2 Department of Biology and Biotechnologies “C. Darwin”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Roma, Italy |
AuthorAffiliation_xml | – name: 2 Department of Biology and Biotechnologies “C. Darwin”, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Roma, Italy – name: 4 Department of Chemistry, Campus Varginha, University of José do Rosário Vellano—UNIFENAS, Alfenas 37130-000, Brazil – name: 3 Consiglio per la Ricerca in Agricoltura e l’Analisi dell’economia Agraria—Centro di Politiche e Bioeconomia, Via Pò 14, 00198 Rome, Italy – name: 1 Department of Chemistry, “Sapienza” University of Rome, p.le A.Moro 5, 00185 Rome, Italy |
Author_xml | – sequence: 1 givenname: Giuseppina orcidid: 0000-0001-9252-8205 surname: Gullifa fullname: Gullifa, Giuseppina organization: Department of Chemistry, "Sapienza" University of Rome, p.le A.Moro 5, 00185 Rome, Italy – sequence: 2 givenname: Roberta orcidid: 0000-0002-6213-5387 surname: Risoluti fullname: Risoluti, Roberta organization: Department of Chemistry, "Sapienza" University of Rome, p.le A.Moro 5, 00185 Rome, Italy – sequence: 3 givenname: Cristina orcidid: 0000-0002-1504-6189 surname: Mazzoni fullname: Mazzoni, Cristina organization: Department of Biology and Biotechnologies "C. Darwin", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Roma, Italy – sequence: 4 givenname: Laura orcidid: 0000-0002-2279-0272 surname: Barone fullname: Barone, Laura organization: Department of Chemistry, "Sapienza" University of Rome, p.le A.Moro 5, 00185 Rome, Italy – sequence: 5 givenname: Elena surname: Papa fullname: Papa, Elena organization: Department of Chemistry, "Sapienza" University of Rome, p.le A.Moro 5, 00185 Rome, Italy – sequence: 6 givenname: Alfredo surname: Battistini fullname: Battistini, Alfredo organization: Consiglio per la Ricerca in Agricoltura e l'Analisi dell'economia Agraria-Centro di Politiche e Bioeconomia, Via Pò 14, 00198 Rome, Italy – sequence: 7 givenname: Rodrigo surname: Martin Fraguas fullname: Martin Fraguas, Rodrigo organization: Department of Chemistry, Campus Varginha, University of José do Rosário Vellano-UNIFENAS, Alfenas 37130-000, Brazil – sequence: 8 givenname: Stefano orcidid: 0000-0002-8468-5291 surname: Materazzi fullname: Materazzi, Stefano organization: Department of Chemistry, "Sapienza" University of Rome, p.le A.Moro 5, 00185 Rome, Italy |
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SubjectTerms | Acids Bacteria Dairy products Dairy Products - microbiology Drying Encapsulation Enumeration Experiments Feeds Food Functional foods & nutraceuticals Humans Lactic acid Lactic acid bacteria Microbial Viability microencapsulation nutraceutics Phase transitions Polymers Probiotics Protective coatings Room temperature Scanning electron microscopy Shelf life Spray Drying Storage stability Thermogravimetric analysis |
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Title | Microencapsulation by a Spray Drying Approach to Produce Innovative Probiotics-Based Products Extending the Shelf-Life in Non-Refrigerated Conditions |
URI | https://www.ncbi.nlm.nih.gov/pubmed/36677918 https://www.proquest.com/docview/2767285234/abstract/ https://search.proquest.com/docview/2768245420 https://pubmed.ncbi.nlm.nih.gov/PMC9862012 https://doaj.org/article/9d1d230d4ec44d98a73e76d86d957b67 |
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