Mesenchymal stem cell-derived exosomal microRNA-133b suppresses glioma progression via Wnt/β-catenin signaling pathway by targeting EZH2

• Published in: Stem cell research & therapy Vol. 10; no. 1; pp. 381 - 14
• Main Authors: Xu, Haiyang, Zhao, Guifang, Zhang, Yu, Jiang, Hong, Wang, Weiyao, Zhao, Donghai, Hong, Jin, Yu, Hongquan, Qi, Ling
• Format: Journal Article
• Language: English
• Published: England BioMed Central 16.12.2019; BMC
• Subjects: Bone marrow; Cell interactions; Cell migration; Cell proliferation; Exosomes; EZH2; Fluorides; Glioma; Glioma cells; Immunoglobulins; Laboratory animals; Medical prognosis; Mesenchymal stem cells; Mesenchyme; Metastases; MicroRNA-133b; MicroRNAs; miRNA; Nervous system; Penicillin; Plasmids; Proteins; Radiation therapy; Signal transduction; Stem cells; Therapeutic applications; Tumors; Wnt protein; Wnt/β-catenin signaling pathway; β-Catenin; United States > US; China; Japan; Glioma; Wnt/β-catenin signaling pathway; Exosomes; MicroRNA-133b; EZH2; Mesenchymal stem cells

Mesenchymal stem cells (MSCs) play a significant role in cancer initiation and metastasis, sometimes by releasing exosomes that mediate cell communication by delivering microRNAs (miRNAs). This study aimed to investigate the effects of exosomal miR-133b derived from MSCs on glioma cell behaviors. Mi...