Evaluation of the Anti-Trypanosomal Activity of Vietnamese Essential Oils, with Emphasis on Curcuma longa L. and Its Components

Human African trypanosomiasis (HAT), known as sleeping sickness and caused by , is threatening low-income populations in sub-Saharan African countries with 61 million people at risk of infection. In order to discover new natural products against HAT, thirty-seven Vietnamese essential oils (EOs) were...

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Published inMolecules (Basel, Switzerland) Vol. 24; no. 6; p. 1158
Main Authors Le, Thanh Binh, Beaufay, Claire, Nghiem, Duc Trong, Pham, Tuan Anh, Mingeot-Leclercq, Marie-Paule, Quetin-Leclercq, Joëlle
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 23.03.2019
MDPI
Subjects
African trypanosomiasis
ar-curcumene
ar-turmerone, curlone
Chromatography
Curcuma longa
Curcuma zedoaria
Cytotoxicity
Essential oils
Gas chromatography
Ginger
Health risks
Litsea cubeba
Mammalian cells
Natural products
Oils & fats
Parasites
Selectivity
Trypanosoma
Trypanosoma brucei
Vector-borne diseases
Zingiber officinale
α-zingiberene, β-sesquiphellandrene
China
Curcuma zedoaria
Trypanosoma
Curcuma longa
Litsea cubeba
α-zingiberene, β-sesquiphellandrene
ar-turmerone, curlone
Zingiber officinale
ar-curcumene
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Abstract Human African trypanosomiasis (HAT), known as sleeping sickness and caused by , is threatening low-income populations in sub-Saharan African countries with 61 million people at risk of infection. In order to discover new natural products against HAT, thirty-seven Vietnamese essential oils (EOs) were screened for their activity in vitro on ( ) and cytotoxicity on mammalian cells (WI38, J774). Based on the selectivity indices (SIs), the more active and selective EOs were analyzed by gas chromatography. The anti-trypanosomal activity and cytotoxicity of some major compounds (isolated or commercial) were also determined. Our results showed for the first time the selective anti-trypanosomal effect of four EOs, extracted from three Zingiberaceae species ( , , and ) and one Lauraceae species ( ) with IC values of 3.17 ± 0.72, 2.51 ± 1.08, 3.10 ± 0.08, and 2.67 ± 1.12 nL/mL respectively and SI > 10. Identified compounds accounted for more than 85% for each of them. Among the five major components of EO, curlone is the most promising anti-trypanosomal candidate with an IC of 1.38 ± 0.45 µg/mL and SIs of 31.7 and 18.2 compared to WI38 and J774 respectively.
AbstractList Human African trypanosomiasis (HAT), known as sleeping sickness and caused by , is threatening low-income populations in sub-Saharan African countries with 61 million people at risk of infection. In order to discover new natural products against HAT, thirty-seven Vietnamese essential oils (EOs) were screened for their activity in vitro on ( ) and cytotoxicity on mammalian cells (WI38, J774). Based on the selectivity indices (SIs), the more active and selective EOs were analyzed by gas chromatography. The anti-trypanosomal activity and cytotoxicity of some major compounds (isolated or commercial) were also determined. Our results showed for the first time the selective anti-trypanosomal effect of four EOs, extracted from three Zingiberaceae species ( , , and ) and one Lauraceae species ( ) with IC values of 3.17 ± 0.72, 2.51 ± 1.08, 3.10 ± 0.08, and 2.67 ± 1.12 nL/mL respectively and SI > 10. Identified compounds accounted for more than 85% for each of them. Among the five major components of EO, curlone is the most promising anti-trypanosomal candidate with an IC of 1.38 ± 0.45 µg/mL and SIs of 31.7 and 18.2 compared to WI38 and J774 respectively.
Human African trypanosomiasis (HAT), known as sleeping sickness and caused by Trypanosoma brucei , is threatening low-income populations in sub-Saharan African countries with 61 million people at risk of infection. In order to discover new natural products against HAT, thirty-seven Vietnamese essential oils (EOs) were screened for their activity in vitro on Trypanosoma brucei brucei ( Tbb ) and cytotoxicity on mammalian cells (WI38, J774). Based on the selectivity indices (SIs), the more active and selective EOs were analyzed by gas chromatography. The anti-trypanosomal activity and cytotoxicity of some major compounds (isolated or commercial) were also determined. Our results showed for the first time the selective anti-trypanosomal effect of four EOs, extracted from three Zingiberaceae species ( Curcuma longa , Curcuma zedoaria , and Zingiber officinale ) and one Lauraceae species ( Litsea cubeba ) with IC 50 values of 3.17 ± 0.72, 2.51 ± 1.08, 3.10 ± 0.08, and 2.67 ± 1.12 nL/mL respectively and SI > 10. Identified compounds accounted for more than 85% for each of them. Among the five major components of Curcuma longa EO, curlone is the most promising anti-trypanosomal candidate with an IC 50 of 1.38 ± 0.45 µg/mL and SIs of 31.7 and 18.2 compared to WI38 and J774 respectively.
Human African trypanosomiasis (HAT), known as sleeping sickness and caused by Trypanosoma brucei, is threatening low-income populations in sub-Saharan African countries with 61 million people at risk of infection. In order to discover new natural products against HAT, thirty-seven Vietnamese essential oils (EOs) were screened for their activity in vitro on Trypanosoma brucei brucei (Tbb) and cytotoxicity on mammalian cells (WI38, J774). Based on the selectivity indices (SIs), the more active and selective EOs were analyzed by gas chromatography. The anti-trypanosomal activity and cytotoxicity of some major compounds (isolated or commercial) were also determined. Our results showed for the first time the selective anti-trypanosomal effect of four EOs, extracted from three Zingiberaceae species (Curcuma longa, Curcuma zedoaria, and Zingiber officinale) and one Lauraceae species (Litsea cubeba) with IC50 values of 3.17 ± 0.72, 2.51 ± 1.08, 3.10 ± 0.08, and 2.67 ± 1.12 nL/mL respectively and SI > 10. Identified compounds accounted for more than 85% for each of them. Among the five major components of Curcuma longa EO, curlone is the most promising anti-trypanosomal candidate with an IC50 of 1.38 ± 0.45 µg/mL and SIs of 31.7 and 18.2 compared to WI38 and J774 respectively.
Human African trypanosomiasis (HAT), known as sleeping sickness and caused by Trypanosoma brucei, is threatening low-income populations in sub-Saharan African countries with 61 million people at risk of infection. In order to discover new natural products against HAT, thirty-seven Vietnamese essential oils (EOs) were screened for their activity in vitro on Trypanosoma brucei brucei (Tbb) and cytotoxicity on mammalian cells (WI38, J774). Based on the selectivity indices (SIs), the more active and selective EOs were analyzed by gas chromatography. The anti-trypanosomal activity and cytotoxicity of some major compounds (isolated or commercial) were also determined. Our results showed for the first time the selective anti-trypanosomal effect of four EOs, extracted from three Zingiberaceae species (Curcuma longa, Curcuma zedoaria, and Zingiber officinale) and one Lauraceae species (Litsea cubeba) with IC50 values of 3.17 ± 0.72, 2.51 ± 1.08, 3.10 ± 0.08, and 2.67 ± 1.12 nL/mL respectively and SI > 10. Identified compounds accounted for more than 85% for each of them. Among the five major components of Curcuma longa EO, curlone is the most promising anti-trypanosomal candidate with an IC50 of 1.38 ± 0.45 µg/mL and SIs of 31.7 and 18.2 compared to WI38 and J774 respectively.
Author Nghiem, Duc Trong
Quetin-Leclercq, Joëlle
Beaufay, Claire
Mingeot-Leclercq, Marie-Paule
Pham, Tuan Anh
Le, Thanh Binh
AuthorAffiliation 2 Department of Pharmacognosy, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoan Kiem, Hanoi 100000, Vietnam; tuananhpharm@hup.edu.vn
4 TFAR Research Group, Louvain Drug Research Institute, Université catholique de Louvain, UCLouvain, 1200 Bruxelles, Belgium; marie-paule.mingeot@uclouvain.be
3 Department of Botany, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoan Kiem, Hanoi 100000, Vietnam; ductrongeb@hup.edu.vn
1 GNOS Research Group, Louvain Drug Research Institute, Université catholique de Louvain, UCLouvain, 1200 Bruxelles, Belgium; claire.beaufay@uclouvain.be
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/30909559$$D View this record in MEDLINE/PubMed
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Issue 6
Keywords Curcuma zedoaria
Trypanosoma
Curcuma longa
Litsea cubeba
α-zingiberene, β-sesquiphellandrene
ar-turmerone, curlone
Zingiber officinale
ar-curcumene
Language English
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Snippet Human African trypanosomiasis (HAT), known as sleeping sickness and caused by , is threatening low-income populations in sub-Saharan African countries with 61...
Human African trypanosomiasis (HAT), known as sleeping sickness and caused by Trypanosoma brucei, is threatening low-income populations in sub-Saharan African...
Human African trypanosomiasis (HAT), known as sleeping sickness and caused by Trypanosoma brucei , is threatening low-income populations in sub-Saharan African...
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StartPage 1158
SubjectTerms African trypanosomiasis
ar-curcumene
ar-turmerone, curlone
Chromatography
Curcuma longa
Curcuma zedoaria
Cytotoxicity
Essential oils
Gas chromatography
Ginger
Health risks
Litsea cubeba
Mammalian cells
Natural products
Oils & fats
Parasites
Selectivity
Trypanosoma
Trypanosoma brucei
Vector-borne diseases
Zingiber officinale
α-zingiberene, β-sesquiphellandrene
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Title Evaluation of the Anti-Trypanosomal Activity of Vietnamese Essential Oils, with Emphasis on Curcuma longa L. and Its Components
URI https://www.ncbi.nlm.nih.gov/pubmed/30909559
https://www.proquest.com/docview/2548931569
https://search.proquest.com/docview/2197886796
https://pubmed.ncbi.nlm.nih.gov/PMC6471621
https://doaj.org/article/ef25ba067c7b48f5ae63f1f014765791
Volume 24
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