Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1 - Il’ina, Irina V.; Dyrkheeva, Nadezhda S.; Zakharenko, Alexandra L.; Sidorenko, Alexander Yu; Li-Zhulanov, Nikolay S.; Korchagina, Dina V.; Chand, Raina; Ayine-Tora, Daniel M.; Chepanova, Arina A.; Zakharova, Olga D.; Ilina, Ekaterina S.; Reynisson, Jóhannes; et al. (Molecules (Basel, Switzerland), 2020)
Keywords: Apoptosis; Bicyclic Monoterpenes - chemistry; Cancer; carene; Cell Proliferation - drug effects; Cell Survival - drug effects; Clay; CRISPR-Cas Systems; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA damage; DNA repair; Drug Design; Drug Synergism; Enzymes; Gene Knockout Techniques; HCT116 Cells; HEK293 Cells; HeLa Cells; Humans; Inhibitory Concentration 50; monoterpene; Phosphodiesterase Inhibitors - chemical synthesis; Phosphodiesterase Inhibitors - chemistry; Phosphodiesterase Inhibitors - pharmacology; Phosphoric Diester Hydrolases - genetics; Phosphoric Diester Hydrolases - metabolism; Signal Transduction - drug effects; synergy; TDP1 gene knockout cells; topotecan; Topotecan - pharmacology; tyrosyl-DNA phosphodiesterase 1; monoterpene; synergy; carene; inhibitor; TDP1 gene knockout cells; tyrosyl-DNA phosphodiesterase 1; topotecan