Repetitive transcranial magnetic stimulation targeting the insular cortex for reduction of heavy drinking in treatment-seeking alcohol-dependent subjects: a randomized controlled trial

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 45; no. 5; pp. 842 - 850
• Main Authors: Perini, Irene, Kämpe, Robin, Arlestig, Theodor, Karlsson, Hanna, Löfberg, Andreas, Pietrzak, Michal, Zangen, Abraham, Heilig, Markus
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.04.2020; Springer International Publishing
• Subjects: Addictions; Alcohol Drinking - physiopathology; Alcohol use; Alcoholism; Alcoholism - physiopathology; Alcoholism - prevention & control; Alcoholism - psychology; Cerebral Cortex - physiopathology; Cortex (insular); Craving - physiology; Double-Blind Method; Drinking behavior; Drug addiction; Female; Humans; Magnetic fields; Magnetic resonance imaging; Male; Middle Aged; Neural networks; Neuroimaging; Nicotine; Prefrontal cortex; Reinforcement; Seeds; Transcranial Magnetic Stimulation

Insula responses to drug cues are correlated with cravings, and lesions in this area reduce nicotine seeking. Here, we investigated the potential efficacy of repetitive transcranial magnetic stimulation (rTMS) targeting the insula in alcohol addiction. Treatment-seeking alcohol-dependent patients (D...