Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 7; p. 1945
• Main Authors: Gladkova, Elizaveta D., Chepanova, Arina A., Ilina, Ekaterina S., Zakharenko, Alexandra L., Reynisson, Jóhannes, Luzina, Olga A., Volcho, Konstantin P., Lavrik, Olga I., Salakhutdinov, Nariman F.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.03.2021; MDPI
• Subjects: berberine; berberrubine; Cancer; Chloride; Crystal structure; DNA repair enzyme; Enzymes; Investigations; Ligands; Liquor; SAR; Tdp1 inhibitor; sulfonate; Tdp1 inhibitor; SAR; molecular modeling; berberrubine; sultone; DNA repair enzyme; cancer; berberine

A new type of berberine derivatives was obtained by the reaction of berberrubine with aliphatic sulfonyl chlorides. The new polycyclic compounds have a sultone ring condensed to C and D rings of a protoberberine core. The reaction conditions were developed to facilitate the formation of sultones wit...