Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 1; p. 99
• Main Authors: Yang, Jing-Hua, Wang, Xin-Yi, Zhou, Yi-Ping, Lu, Rong, Chen, Chin-Ho, Zhang, Meng-Han, Cheng, Yung-Yi, Morris-Natschke, Susan L., Lee, Kuo-Hsiung, Wang, Yun-Song
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.12.2019; MDPI
• Subjects: Acquired immune deficiency syndrome; AIDS; Alkaloids - chemistry; Alkaloids - isolation & purification; Alkaloids - pharmacology; anti-hiv; carbazole alkaloids; Carbazoles - chemistry; Carbazoles - isolation & purification; Carbazoles - pharmacology; Carbon; Cell Line; Clausena - chemistry; clausena anisum-olens; HIV; HIV-1 - drug effects; HIV-1 - physiology; Human immunodeficiency virus; Humans; Hydrocarbons; Magnetic Resonance Spectroscopy; Molecular Structure; Natural products; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; rutaceae; Traditional medicine; Virus Replication - drug effects; China; anti-HIV; carbazole alkaloids; Rutaceae; Clausena anisum-olens
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules25010099

Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3–8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1–8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.