Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation

Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3–8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1–8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocy...

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Published inMolecules (Basel, Switzerland) Vol. 25; no. 1; p. 99
Main Authors Yang, Jing-Hua, Wang, Xin-Yi, Zhou, Yi-Ping, Lu, Rong, Chen, Chin-Ho, Zhang, Meng-Han, Cheng, Yung-Yi, Morris-Natschke, Susan L., Lee, Kuo-Hsiung, Wang, Yun-Song
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 26.12.2019
MDPI
Subjects
Acquired immune deficiency syndrome
AIDS
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
anti-hiv
carbazole alkaloids
Carbazoles - chemistry
Carbazoles - isolation & purification
Carbazoles - pharmacology
Carbon
Cell Line
Clausena - chemistry
clausena anisum-olens
HIV
HIV-1 - drug effects
HIV-1 - physiology
Human immunodeficiency virus
Humans
Hydrocarbons
Magnetic Resonance Spectroscopy
Molecular Structure
Natural products
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
rutaceae
Traditional medicine
Virus Replication - drug effects
China
anti-HIV
carbazole alkaloids
Rutaceae
Clausena anisum-olens
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Abstract Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3–8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1–8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.
AbstractList Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3–8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1–8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.
Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3−8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1−8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.
Two new carbazole alkaloids ( , ) and six known carbazole alkaloids ( - ) were isolated from . Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds ( - ) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1 Nanoluc-sec virus, and new carbazole alkaloid exhibited anti-HIV activity with an EC value of 2.4 μg/mL and SI of 7.1.
Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3-8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1-8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3-8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1-8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.
Two new carbazole alkaloids ( 1 , 2 ) and six known carbazole alkaloids ( 3 – 8 ) were isolated from Clausena anisum-olens . Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds ( 1 – 8 ) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1 NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC 50 value of 2.4 μg/mL and SI of 7.1.
Author Zhou, Yi-Ping
Lu, Rong
Chen, Chin-Ho
Wang, Yun-Song
Lee, Kuo-Hsiung
Yang, Jing-Hua
Morris-Natschke, Susan L.
Zhang, Meng-Han
Wang, Xin-Yi
Cheng, Yung-Yi
AuthorAffiliation 2 The High School Affiliated to Yunnan Normal University, Kunming 650106, China; wxyyn2019@163.com
5 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA yungyi@email.unc.edu (Y.-Y.C.); susan_natschke@unc.edu (S.L.M.-N.)
6 Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan
4 Surgical Science, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA; chc@duke.edu
1 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China; yangjh@ynu.edu.cn (J.-H.Y.); yangynu@126.com (R.L.)
3 School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China; zhouypym@foxmail.com
AuthorAffiliation_xml – name: 4 Surgical Science, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA; chc@duke.edu
– name: 1 Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China; yangjh@ynu.edu.cn (J.-H.Y.); yangynu@126.com (R.L.)
– name: 6 Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan
– name: 2 The High School Affiliated to Yunnan Normal University, Kunming 650106, China; wxyyn2019@163.com
– name: 5 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA yungyi@email.unc.edu (Y.-Y.C.); susan_natschke@unc.edu (S.L.M.-N.)
– name: 3 School of Pharmaceutical Sciences & Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, China; zhouypym@foxmail.com
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Keywords anti-HIV
carbazole alkaloids
Rutaceae
Clausena anisum-olens
Language English
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Snippet Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3–8) were isolated from Clausena anisum-olens. Their structures were elucidated based on...
Two new carbazole alkaloids ( , ) and six known carbazole alkaloids ( - ) were isolated from . Their structures were elucidated based on extensive...
Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3-8) were isolated from Clausena anisum-olens. Their structures were elucidated based on...
Two new carbazole alkaloids ( 1 , 2 ) and six known carbazole alkaloids ( 3 – 8 ) were isolated from Clausena anisum-olens . Their structures were elucidated...
Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3−8) were isolated from Clausena anisum-olens. Their structures were elucidated based on...
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SubjectTerms Acquired immune deficiency syndrome
AIDS
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
anti-hiv
carbazole alkaloids
Carbazoles - chemistry
Carbazoles - isolation & purification
Carbazoles - pharmacology
Carbon
Cell Line
Clausena - chemistry
clausena anisum-olens
HIV
HIV-1 - drug effects
HIV-1 - physiology
Human immunodeficiency virus
Humans
Hydrocarbons
Magnetic Resonance Spectroscopy
Molecular Structure
Natural products
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
rutaceae
Traditional medicine
Virus Replication - drug effects
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Title Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation
URI https://www.ncbi.nlm.nih.gov/pubmed/31888067
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