The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 43; no. 10; pp. 2154 - 2160
• Main Authors: Abdallah, Chadi G., De Feyter, Henk M., Averill, Lynnette A., Jiang, Lihong, Averill, Christopher L., Chowdhury, Golam M. I., Purohit, Prerana, de Graaf, Robin A., Esterlis, Irina, Juchem, Christoph, Pittman, Brian P., Krystal, John H., Rothman, Douglas L., Sanacora, Gerard, Mason, Graeme F.
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.09.2018; Springer International Publishing
• Subjects: Adult; Aged; Antidepressive Agents - pharmacology; Carbon 13; Cortex (frontal); Depressive Disorder - physiopathology; Energy Metabolism - drug effects; Excitatory Amino Acid Antagonists - pharmacology; Female; Glutamate receptors; Glutamates - physiology; Glutamic acid receptors (ionotropic); Glutamine; Hallucinogens - pharmacology; Healthy Volunteers; Humans; Ketamine; Ketamine - pharmacology; Magnetic Resonance Spectroscopy; Male; Mental disorders; Middle Aged; N-Methyl-D-aspartic acid receptors; Neurotransmission; Pilot Projects; Prefrontal cortex; Prefrontal Cortex - drug effects; Prefrontal Cortex - metabolism; Rodents; Schizophrenia; Synaptic Transmission - drug effects; Young Adult

The ability of ketamine administration to activate prefrontal glutamate neurotransmission is thought to be a key mechanism contributing to its transient psychotomimetic effects and its delayed and sustained antidepressant effects. Rodent studies employing carbon-13 magnetic resonance spectroscopy (...