Bispidine Platform as a Tool for Studying Amide Configuration Stability

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 2; p. 430
• Main Authors: Krut’ko, Dmitry P., Medved’ko, Alexey V., Lyssenko, Konstantin A., Churakov, Andrei V., Dalinger, Alexander I., Kalinin, Mikhail A., Gudovannyy, Alexey O., Ponomarev, Konstantin Y., Suslov, Eugeny V., Vatsadze, Sergey Z.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 10.01.2022; MDPI
• Subjects: 3,7-diazabicyclo[3.3.1]nonanes; Acids; barriers of amide rotation; Dopamine; dynamic stereochemistry; Hydrocarbons; NMR spectroscopy; quantum chemical calculations; Severe acute respiratory syndrome coronavirus 2; Solvents; Symmetry; X-ray diffraction study; 3,7-diazabicyclo[3.3.1]nonanes; dynamic stereochemistry; quantum chemical calculations; NMR spectroscopy; X-ray diffraction study; barriers of amide rotation

In this work, the solution conformations of seventeen 3,7-diacyl bispidines were studied by means of NMR spectroscopy including VT NMR experiments. The acyl groups included alkyl, alkenyl, aryl, hetaryl, and ferrocene moieties. The presence of syn/anti-isomers and their ratios were estimated, and so...