A Proteomic Investigation to Discover Candidate Proteins Involved in Novel Mechanisms of 5-Fluorouracil Resistance in Colorectal Cancer

• Published in: Cells (Basel, Switzerland) Vol. 13; no. 4; p. 342
• Main Authors: Ortega Duran, Mario, Shaheed, Sadr ul, Sutton, Christopher W., Shnyder, Steven D.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2024
• Subjects: 5-Fluorouracil; Amino acids; Cancer therapies; Causes of; CD44 antigen; CD63 antigen; Cell culture; Cell cycle; Cell Line, Tumor; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - metabolism; Dosage and administration; Drug development; Drug resistance; drug resistance mechanisms; Drug Resistance, Neoplasm; Drug therapy; Fluorouracil; Fluorouracil - pharmacology; Fluorouracil - therapeutic use; Genomics; Health aspects; Humans; in vitro models; Labeling; Liquid chromatography; Mass spectroscopy; Metabolism; Metabolites; Mucoproteins; Oncogene Proteins; Peptides; Proteins; Proteomics; stable isotope labelling with amino acids in cell culture (SILAC); Tumorigenesis; United Kingdom; United Kingdom > UK; 5-fluorouracil; colorectal cancer; drug resistance mechanisms; proteomics; in vitro models; stable isotope labelling with amino acids in cell culture (SILAC)

One of the main obstacles to therapeutic success in colorectal cancer (CRC) is the development of acquired resistance to treatment with drugs such as 5-fluorouracil (5-FU). Whilst some resistance mechanisms are well known, it is clear from the stasis in therapy success rate that much is still unknow...