Multistability in the epithelial-mesenchymal transition network

• Published in: BMC bioinformatics Vol. 21; no. 1; pp. 71 - 17
• Main Authors: Xin, Ying, Cummins, Bree, Gedeon, Tomáš
• Format: Journal Article
• Language: English
• Published: England BioMed Central 24.02.2020; BMC
• Subjects: Biomarkers; Boolean; Cancer; Cell adhesion & migration; Complex systems; Epithelial-Mesenchymal Transition; Genotype & phenotype; Medical prognosis; Mesenchyme; Metastasis; Models, Biological; Motility; Multistability; Network models; Phenotype; Software; Epithelial-mesenchymal transition; Multistability; Network models

The transitions between epithelial (E) and mesenchymal (M) cell phenotypes are essential in many biological processes like tissue development and cancer metastasis. Previous studies, both modeling and experimental, suggested that in addition to E and M states, the network responsible for these pheno...