Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review

Green tea is one of the most popular beverages in the world, especially in Asian countries. Consumption of green tea has been demonstrated to possess many health benefits, which mainly attributed to the main bioactive compound epigallocatechin gallate (EGCG), a flavone-3-ol polyphenol, in green tea....

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Published inCritical reviews in food science and nutrition Vol. 58; no. 6; pp. 924 - 941
Main Authors Gan, Ren-You, Li, Hua-Bin, Sui, Zhong-Quan, Corke, Harold
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 13.04.2018
Taylor & Francis Ltd
Subjects
Absorption
Animals
anti-cancer effect
Anticancer properties
antineoplastic activity
Antineoplastic Agents - pharmacokinetics
Asia
Beverages
Bioactive compounds
Biological activity
Cancer
cancer stem cells
Catechin - analogs & derivatives
Catechin - pharmacokinetics
Cell Line, Tumor
chemoprevention
Drug Synergism
drug therapy
Epigallocatechin gallate
Green tea
gut microbiota
Humans
Intestinal microflora
intestinal microorganisms
Intestine
intestines
Metabolism
Microbiota
molecular targets
Nanoparticles
neoplasms
Neoplasms - prevention & control
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - metabolism
polyphenols
Polyphenols - pharmacokinetics
Stem cells
Tea
Tea - chemistry
Asia
nanoparticles
cancer stem cells
anti-cancer effect
Metabolism
molecular targets
gut microbiota
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Abstract Green tea is one of the most popular beverages in the world, especially in Asian countries. Consumption of green tea has been demonstrated to possess many health benefits, which mainly attributed to the main bioactive compound epigallocatechin gallate (EGCG), a flavone-3-ol polyphenol, in green tea. EGCG is mainly absorbed in the intestine, and gut microbiota play a critical role in its metabolism prior to absorption. EGCG exhibits versatile bioactivities, with its anti-cancer effect most attracting due to the cancer preventive effect of green tea consumption, and a great number of studies intensively investigated its anti-cancer effect. In this review, we therefore, first stated the absorption and metabolism process of EGCG, and then summarized its anti-cancer effect in vitro and in vivo, including its manifold anti-cancer actions and mechanisms, especially its anti-cancer stem cell effect, and next highlighted its various molecular targets involved in cancer inhibition. Finally, the anti-cancer effect of EGCG analogs and nanoparticles, as well as the potential cancer promoting effect of EGCG were also discussed. Understanding of the absorption, metabolism, anti-cancer effect and molecular targets of EGCG can be of importance to better utilize it as a chemopreventive and chemotherapeutic agent.
AbstractList Green tea is one of the most popular beverages in the world, especially in Asian countries. Consumption of green tea has been demonstrated to possess many health benefits, which mainly attributed to the main bioactive compound epigallocatechin gallate (EGCG), a flavone-3-ol polyphenol, in green tea. EGCG is mainly absorbed in the intestine, and gut microbiota play a critical role in its metabolism prior to absorption. EGCG exhibits versatile bioactivities, with its anti-cancer effect most attracting due to the cancer preventive effect of green tea consumption, and a great number of studies intensively investigated its anti-cancer effect. In this review, we therefore, first stated the absorption and metabolism process of EGCG, and then summarized its anti-cancer effect in vitro and in vivo, including its manifold anti-cancer actions and mechanisms, especially its anti-cancer stem cell effect, and next highlighted its various molecular targets involved in cancer inhibition. Finally, the anti-cancer effect of EGCG analogs and nanoparticles, as well as the potential cancer promoting effect of EGCG were also discussed. Understanding of the absorption, metabolism, anti-cancer effect and molecular targets of EGCG can be of importance to better utilize it as a chemopreventive and chemotherapeutic agent.Green tea is one of the most popular beverages in the world, especially in Asian countries. Consumption of green tea has been demonstrated to possess many health benefits, which mainly attributed to the main bioactive compound epigallocatechin gallate (EGCG), a flavone-3-ol polyphenol, in green tea. EGCG is mainly absorbed in the intestine, and gut microbiota play a critical role in its metabolism prior to absorption. EGCG exhibits versatile bioactivities, with its anti-cancer effect most attracting due to the cancer preventive effect of green tea consumption, and a great number of studies intensively investigated its anti-cancer effect. In this review, we therefore, first stated the absorption and metabolism process of EGCG, and then summarized its anti-cancer effect in vitro and in vivo, including its manifold anti-cancer actions and mechanisms, especially its anti-cancer stem cell effect, and next highlighted its various molecular targets involved in cancer inhibition. Finally, the anti-cancer effect of EGCG analogs and nanoparticles, as well as the potential cancer promoting effect of EGCG were also discussed. Understanding of the absorption, metabolism, anti-cancer effect and molecular targets of EGCG can be of importance to better utilize it as a chemopreventive and chemotherapeutic agent.
Green tea is one of the most popular beverages in the world, especially in Asian countries. Consumption of green tea has been demonstrated to possess many health benefits, which mainly attributed to the main bioactive compound epigallocatechin gallate (EGCG), a flavone-3-ol polyphenol, in green tea. EGCG is mainly absorbed in the intestine, and gut microbiota play a critical role in its metabolism prior to absorption. EGCG exhibits versatile bioactivities, with its anti-cancer effect most attracting due to the cancer preventive effect of green tea consumption, and a great number of studies intensively investigated its anti-cancer effect. In this review, we therefore, first stated the absorption and metabolism process of EGCG, and then summarized its anti-cancer effect in vitro and in vivo, including its manifold anti-cancer actions and mechanisms, especially its anti-cancer stem cell effect, and next highlighted its various molecular targets involved in cancer inhibition. Finally, the anti-cancer effect of EGCG analogs and nanoparticles, as well as the potential cancer promoting effect of EGCG were also discussed. Understanding of the absorption, metabolism, anti-cancer effect and molecular targets of EGCG can be of importance to better utilize it as a chemopreventive and chemotherapeutic agent.
Author Sui, Zhong-Quan
Li, Hua-Bin
Gan, Ren-You
Corke, Harold
Author_xml – sequence: 1
  givenname: Ren-You
  orcidid: 0000-0002-4162-1511
  surname: Gan
  fullname: Gan, Ren-You
  organization: School of Biological Sciences, The University of Hong Kong
– sequence: 2
  givenname: Hua-Bin
  surname: Li
  fullname: Li, Hua-Bin
  organization: Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-Sen University
– sequence: 3
  givenname: Zhong-Quan
  surname: Sui
  fullname: Sui, Zhong-Quan
  email: springsui@gmail.com
  organization: Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiao Tong University
– sequence: 4
  givenname: Harold
  surname: Corke
  fullname: Corke, Harold
  email: hcorke@yahoo.com
  organization: School of Biological Sciences, The University of Hong Kong
BackLink https://www.ncbi.nlm.nih.gov/pubmed/27645804$$D View this record in MEDLINE/PubMed
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Snippet Green tea is one of the most popular beverages in the world, especially in Asian countries. Consumption of green tea has been demonstrated to possess many...
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SubjectTerms Absorption
Animals
anti-cancer effect
Anticancer properties
antineoplastic activity
Antineoplastic Agents - pharmacokinetics
Asia
Beverages
Bioactive compounds
Biological activity
Cancer
cancer stem cells
Catechin - analogs & derivatives
Catechin - pharmacokinetics
Cell Line, Tumor
chemoprevention
Drug Synergism
drug therapy
Epigallocatechin gallate
Green tea
gut microbiota
Humans
Intestinal microflora
intestinal microorganisms
Intestine
intestines
Metabolism
Microbiota
molecular targets
Nanoparticles
neoplasms
Neoplasms - prevention & control
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - metabolism
polyphenols
Polyphenols - pharmacokinetics
Stem cells
Tea
Tea - chemistry
Title Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review
URI https://www.tandfonline.com/doi/abs/10.1080/10408398.2016.1231168
https://www.ncbi.nlm.nih.gov/pubmed/27645804
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https://www.proquest.com/docview/2067287673
Volume 58
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