Enhanced Anti-Inflammatory Effect of the Combination of Lactiplantibacillus plantarum LS/07 with Methotrexate Compared to Their Monotherapies Studied in Experimental Arthritis

The gut microbiome (GM) of rheumatic arthritis (RA) patients is often altered in composition and function. Moreover, methotrexate (MTX), one of the most frequently used disease-modifying antirheumatic drugs, is known to negatively affect GM composition. The modulation of immune system activity is on...

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Published inMolecules (Basel, Switzerland) Vol. 28; no. 1; p. 297
Main Authors Pružinská, Katarína, Slovák, Lukáš, Dráfi, František, Poništ, Silvester, Juránek, Ivo, Chrastina, Martin, Švík, Karol, Strojný, Ladislav, Ambro, Ľuboš, Bauerová, Katarína
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 30.12.2022
MDPI
Subjects
adjuvant arthritis
Animals
Arthritis
Bacteria
Biometrics
Chemical compounds
Composition
Cytokines
Disease
Etiology
Experiments
Gelatinase B
Immune system
Immunosuppressive agents
Inflammation
Inflammatory bowel disease
Intestinal microflora
Joint diseases
Lactiplantibacillus plantarum LS/07
Lactobacilli
Methotrexate
Microbiomes
Microbiota
Monocyte chemoattractant protein 1
Pharmaceuticals
Probiotics
γ-Glutamyltransferase
inflammation
Lactobacilli
methotrexate
adjuvant arthritis
immune modulation
Lactiplantibacillus plantarum LS/07
probiotics
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Abstract The gut microbiome (GM) of rheumatic arthritis (RA) patients is often altered in composition and function. Moreover, methotrexate (MTX), one of the most frequently used disease-modifying antirheumatic drugs, is known to negatively affect GM composition. The modulation of immune system activity is one of the therapeutic benefits of probiotics. The aim of the current investigation was to determine the impact of MTX therapy combined with one of the Lactobacillus strains, LS/07 (LB), on adjuvant arthritis (AA) in rats. Methods focused on biometric and inflammatory parameters in AA, particularly on plasmatic levels of IL-17A, MMP-9, and MCP-1, and the activities of gamma-glutamyl transferase in the spleen and joints were applied. Enhancing the effect of MTX, LB positively influenced all biometric and inflammatory parameters. The findings of the present study may be of help in proposing novel therapeutic strategies for RA patients.
AbstractList The gut microbiome (GM) of rheumatic arthritis (RA) patients is often altered in composition and function. Moreover, methotrexate (MTX), one of the most frequently used disease-modifying antirheumatic drugs, is known to negatively affect GM composition. The modulation of immune system activity is one of the therapeutic benefits of probiotics. The aim of the current investigation was to determine the impact of MTX therapy combined with one of the Lactobacillus strains, Lactoplantibacillus plantarum LS/07 (LB), on adjuvant arthritis (AA) in rats. Methods focused on biometric and inflammatory parameters in AA, particularly on plasmatic levels of IL-17A, MMP-9, and MCP-1, and the activities of gamma-glutamyl transferase in the spleen and joints were applied. Enhancing the effect of MTX, LB positively influenced all biometric and inflammatory parameters. The findings of the present study may be of help in proposing novel therapeutic strategies for RA patients.
The gut microbiome (GM) of rheumatic arthritis (RA) patients is often altered in composition and function. Moreover, methotrexate (MTX), one of the most frequently used disease-modifying antirheumatic drugs, is known to negatively affect GM composition. The modulation of immune system activity is one of the therapeutic benefits of probiotics. The aim of the current investigation was to determine the impact of MTX therapy combined with one of the Lactobacillus strains, Lactoplantibacillus plantarum LS/07 (LB), on adjuvant arthritis (AA) in rats. Methods focused on biometric and inflammatory parameters in AA, particularly on plasmatic levels of IL-17A, MMP-9, and MCP-1, and the activities of gamma-glutamyl transferase in the spleen and joints were applied. Enhancing the effect of MTX, LB positively influenced all biometric and inflammatory parameters. The findings of the present study may be of help in proposing novel therapeutic strategies for RA patients.
The gut microbiome (GM) of rheumatic arthritis (RA) patients is often altered in composition and function. Moreover, methotrexate (MTX), one of the most frequently used disease-modifying antirheumatic drugs, is known to negatively affect GM composition. The modulation of immune system activity is one of the therapeutic benefits of probiotics. The aim of the current investigation was to determine the impact of MTX therapy combined with one of the Lactobacillus strains, LS/07 (LB), on adjuvant arthritis (AA) in rats. Methods focused on biometric and inflammatory parameters in AA, particularly on plasmatic levels of IL-17A, MMP-9, and MCP-1, and the activities of gamma-glutamyl transferase in the spleen and joints were applied. Enhancing the effect of MTX, LB positively influenced all biometric and inflammatory parameters. The findings of the present study may be of help in proposing novel therapeutic strategies for RA patients.
Author Chrastina, Martin
Slovák, Lukáš
Bauerová, Katarína
Pružinská, Katarína
Švík, Karol
Juránek, Ivo
Dráfi, František
Poništ, Silvester
Strojný, Ladislav
Ambro, Ľuboš
AuthorAffiliation 4 Center for Interdisciplinary Biosciences, Technology and Innovation Park, Pavol Jozef Šafárik University, Jesenná 5, 04001 Košice, Slovakia
1 Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dúbravská cesta 9, 84104 Bratislava, Slovakia
3 Center of Clinical and Preclinical Research, Faculty of Medicine, Pavol Jozef Šafárik University, Trieda SNP 1, 04011 Košice, Slovakia
2 Jessenius Faculty of Medicine in Martin, Comenius University, Malá Hora 4A, 03601 Martin, Slovakia
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Cites_doi 10.1038/nrgastro.2010.117
10.3390/ijms19102938
10.1038/s41591-019-0439-x
10.1038/s41575-019-0173-3
10.1016/j.biopha.2017.07.138
10.1016/j.ctcp.2020.101207
10.1111/fcp.12085
10.1007/s10875-010-9457-7
10.3390/nu12051456
10.1016/j.coi.2011.07.006
10.1002/art.1780370802
10.1001/jama.2012.3507
10.3390/molecules22111911
10.1016/j.phanu.2020.100228
10.1007/s12223-009-0045-2
10.1159/000342079
10.1111/imm.12765
10.1093/rheumatology/33.11.1030
10.3390/nu9091021
10.1039/C9FO02556A
10.3390/ph15101293
10.3390/ijms18102185
10.20944/preprints201809.0397.v1
10.1073/pnas.67.3.1248
10.1093/advances/nmy063
10.2478/acve-2018-0005
10.1007/s11756-022-01111-w
10.18388/abp.2015_1008
10.1038/srep30594
10.17221/7497-CJAS
10.1016/j.molimm.2007.12.010
10.1038/nm.3914
10.1007/s10067-017-3814-3
10.1007/s00383-019-04547-5
10.3858/emm.2008.40.2.237
10.33549/physiolres.934328
10.1017/S0029665110001527
10.2754/avb201281020189
10.1016/j.tim.2015.03.002
10.1093/rheumatology/kew374
10.1016/j.cytogfr.2009.11.006
10.1038/s41598-017-10471-2
10.1002/1529-0131(200110)44:10<2263::AID-ART389>3.0.CO;2-1
10.1359/jbmr.070726
10.1016/j.nut.2013.09.007
10.1007/s12602-017-9322-6
10.1111/1756-185X.12888
10.1002/1529-0131(200109)44:9<2176::AID-ART371>3.0.CO;2-4
10.1007/s00296-011-2177-3
10.1111/j.1365-2249.1993.tb05938.x
10.1007/s10787-017-0436-y
10.1186/s13073-016-0299-7
10.1186/s40168-019-0719-1
10.1038/nrgastro.2014.66
10.1186/ar149
10.1089/jir.2012.0034
10.1038/ismej.2016.13
10.1038/nrrheum.2016.85
10.1111/1756-185X.12333
10.3389/fimmu.2014.00461
10.1038/nrrheum.2016.166
10.1080/08923973.2018.1434793
10.17221/56/2010-CJAS
10.1155/2013/135142
10.1097/BOR.0000000000000008
10.1007/s10787-016-0277-0
10.1146/annurev.immunol.021908.132612
10.1172/JCI115950
10.1016/j.pharep.2013.09.007
10.1016/j.medmal.2013.10.002
10.1007/s00284-013-0338-1
10.1038/nrd1109
10.3389/fimmu.2021.578386
10.4149/gpb_2017014
10.4149/neo_2010_05_422
10.1080/03009740310003695
10.3390/nu13041268
10.3389/fphar.2021.711788
10.1155/2015/206731
10.3390/ijms22062805
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Issue 1
Keywords inflammation
Lactobacilli
methotrexate
adjuvant arthritis
immune modulation
Lactiplantibacillus plantarum LS/07
probiotics
Language English
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References Marzorati (ref_42) 2016; 12
Wang (ref_43) 2016; 24
Cristofori (ref_48) 2021; 12
Matha (ref_65) 2004; 11
Langerholc (ref_39) 2017; 94
Zamani (ref_27) 2016; 19
Liu (ref_29) 2016; 6
Hill (ref_5) 2014; 11
Gil (ref_49) 2019; 10
Tsiklauri (ref_75) 2019; 68
ref_11
ref_55
ref_53
Rudbane (ref_61) 2018; 26
(ref_64) 2009; 54
Gareau (ref_8) 2010; 7
Mohammed (ref_12) 2017; 36
Salaj (ref_40) 2015; 62
Weber (ref_47) 2018; 10
Chen (ref_21) 2016; 8
Hatakka (ref_26) 2003; 32
Ferro (ref_10) 2021; 12
Alipour (ref_24) 2014; 17
Cho (ref_74) 2008; 40
Chmelarova (ref_31) 2010; 57
Zhang (ref_7) 2016; 10
Derrien (ref_14) 2015; 23
ref_60
Leite (ref_1) 2017; 152
Pan (ref_45) 2019; 7
Salaj (ref_38) 2015; 2
Bi (ref_13) 2019; 35
Bomba (ref_32) 2011; 56
So (ref_57) 2008; 45
ref_68
Butel (ref_9) 2014; 44
Gil (ref_46) 2012; 61
ref_22
Fan (ref_63) 2020; 11
Ponist (ref_86) 2020; 14
Bhat (ref_17) 2017; 7
Brusca (ref_4) 2014; 26
Bomba (ref_33) 2012; 81
Smolen (ref_56) 2003; 2
Zhang (ref_20) 2015; 21
Wang (ref_84) 2022; 77
Amdekar (ref_58) 2011; 31
Azad (ref_52) 2018; 2018
Janega (ref_67) 2012; 32
Szabados (ref_34) 2014; 59
Alipour (ref_25) 2014; 30
Katz (ref_73) 2001; 44
Salaj (ref_37) 2013; 2013
Gil (ref_19) 2015; 2015
Hayashida (ref_79) 2001; 3
Kuncirova (ref_76) 2014; 28
Fedorova (ref_82) 2017; 36
Lawrence (ref_69) 2010; 21
Vincenti (ref_80) 1994; 37
Dinarello (ref_70) 2009; 27
Bobrov (ref_35) 2014; 9
Bobrov (ref_36) 2016; 6
ref_77
Gaffen (ref_71) 2011; 23
Chmelarova (ref_41) 2018; 68
Ishizuka (ref_66) 2007; 22
Liu (ref_23) 2013; 67
Ondrejickova (ref_88) 1993; 4
McCulloch (ref_2) 1993; 92
ref_83
Hempel (ref_18) 2012; 307
Jethwa (ref_59) 2016; 56
Eerola (ref_3) 1994; 33
Koch (ref_78) 1992; 90
Orlowski (ref_87) 1970; 67
Amdekar (ref_62) 2013; 33
Choudhary (ref_85) 2018; 40
Gil (ref_51) 2010; 69
Lowe (ref_44) 2020; 40
Chen (ref_30) 2015; 2015
Schett (ref_72) 2016; 12
Kawasaki (ref_50) 2014; 5
Sanders (ref_15) 2019; 16
Szczepanik (ref_28) 2014; 66
Cavalcanti (ref_54) 2015; 6
Cunnane (ref_81) 2001; 44
Suez (ref_16) 2019; 25
ref_6
References_xml – volume: 7
  start-page: 503
  year: 2010
  ident: ref_8
  article-title: Probiotics and the gut microbiota in intestinal health and disease
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/nrgastro.2010.117
  contributor:
    fullname: Gareau
– ident: ref_22
  doi: 10.3390/ijms19102938
– volume: 25
  start-page: 716
  year: 2019
  ident: ref_16
  article-title: The pros, cons, and many unknowns of probiotics
  publication-title: Nat. Med.
  doi: 10.1038/s41591-019-0439-x
  contributor:
    fullname: Suez
– volume: 16
  start-page: 605
  year: 2019
  ident: ref_15
  article-title: Probiotics and prebiotics in intestinal health and disease: From biology to the clinic
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/s41575-019-0173-3
  contributor:
    fullname: Sanders
– volume: 94
  start-page: 1176
  year: 2017
  ident: ref_39
  article-title: Cytokine production in vitro and in rat model of colitis in response to Lactobacillus plantarum LS/07
  publication-title: Biomed. Pharmacother.
  doi: 10.1016/j.biopha.2017.07.138
  contributor:
    fullname: Langerholc
– volume: 40
  start-page: 101207
  year: 2020
  ident: ref_44
  article-title: A Systematic Review of the Effects of Probiotic Administration in Inflammatory Arthritis
  publication-title: Complement Ther. Clin. Pract.
  doi: 10.1016/j.ctcp.2020.101207
  contributor:
    fullname: Lowe
– volume: 28
  start-page: 616
  year: 2014
  ident: ref_76
  article-title: N-feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis
  publication-title: Fundam. Clin. Pharmacol.
  doi: 10.1111/fcp.12085
  contributor:
    fullname: Kuncirova
– volume: 31
  start-page: 147
  year: 2011
  ident: ref_58
  article-title: Lactobacillus casei reduces the Inflammatory Joint Damage Associated with Collagen-Induced Arthritis (CIA) by Reducing the Pro-Inflammatory Cytokines: Lactobacillus casei: COX-2 inhibitor
  publication-title: J. Clin. Immunol.
  doi: 10.1007/s10875-010-9457-7
  contributor:
    fullname: Amdekar
– ident: ref_6
  doi: 10.3390/nu12051456
– volume: 23
  start-page: 613
  year: 2011
  ident: ref_71
  article-title: Recent advances in the IL-17 cytokine family
  publication-title: Curr. Opin. Immunol.
  doi: 10.1016/j.coi.2011.07.006
  contributor:
    fullname: Gaffen
– volume: 37
  start-page: 1115
  year: 1994
  ident: ref_80
  article-title: Using inhibitors of metalloproteinases to treat arthritis. Easier said than done?
  publication-title: Arthritis Rheumatol.
  doi: 10.1002/art.1780370802
  contributor:
    fullname: Vincenti
– volume: 307
  start-page: 1959
  year: 2012
  ident: ref_18
  article-title: Probiotics for the prevention and treatment of antibiotic-associated diarrhea: A systematic review and meta-analysis
  publication-title: JAMA
  doi: 10.1001/jama.2012.3507
  contributor:
    fullname: Hempel
– ident: ref_77
  doi: 10.3390/molecules22111911
– volume: 14
  start-page: 100228
  year: 2020
  ident: ref_86
  article-title: Modulation of Methotrexate Efficacy by Green Tea Polyphenols in Rat Adjuvant Arthritis
  publication-title: PharmaNutrition
  doi: 10.1016/j.phanu.2020.100228
  contributor:
    fullname: Ponist
– volume: 54
  start-page: 359
  year: 2009
  ident: ref_64
  article-title: Treatment of adjuvant-induced arthritis with the combination of methotrexate and probiotic bacteria Escherichia coli O83 (Colinfant)
  publication-title: Folia Microbiol.
  doi: 10.1007/s12223-009-0045-2
– volume: 61
  start-page: 160
  year: 2012
  ident: ref_46
  article-title: Probiotic Mechanisms of Action
  publication-title: Ann. Nutr. Metab.
  doi: 10.1159/000342079
  contributor:
    fullname: Gil
– volume: 152
  start-page: 1
  year: 2017
  ident: ref_1
  article-title: Intestinal dysbiosis and probiotic applications in autoimmune diseases
  publication-title: Immunology
  doi: 10.1111/imm.12765
  contributor:
    fullname: Leite
– volume: 33
  start-page: 1030
  year: 1994
  ident: ref_3
  article-title: Intestinal flora in early rheumatoid arthritis
  publication-title: Br. J. Rheumatol.
  doi: 10.1093/rheumatology/33.11.1030
  contributor:
    fullname: Eerola
– ident: ref_55
  doi: 10.3390/nu9091021
– volume: 11
  start-page: 3681
  year: 2020
  ident: ref_63
  article-title: The prophylactic effects of different Lactobacilli on collagen-induced arthritis in rats
  publication-title: Food Funct.
  doi: 10.1039/C9FO02556A
  contributor:
    fullname: Fan
– ident: ref_83
  doi: 10.3390/ph15101293
– ident: ref_11
  doi: 10.3390/ijms18102185
– ident: ref_53
  doi: 10.20944/preprints201809.0397.v1
– volume: 67
  start-page: 1248
  year: 1970
  ident: ref_87
  article-title: The γ-Glutamyl Cycle: A Possible Transport System for Amino Acids*
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.67.3.1248
  contributor:
    fullname: Orlowski
– volume: 10
  start-page: S49
  year: 2019
  ident: ref_49
  article-title: Mechanisms of Action of Probiotics
  publication-title: Adv. Nutr.
  doi: 10.1093/advances/nmy063
  contributor:
    fullname: Gil
– volume: 4
  start-page: 225
  year: 1993
  ident: ref_88
  article-title: Evaluation of ischemia-reperfusion injury by malondialdehyde, glutathione and gamma-glutamyl transpeptidase: Lack of specific local effects in diverse parts of the dog heart following acute coronary occlusion
  publication-title: Cardioscience
  contributor:
    fullname: Ondrejickova
– volume: 68
  start-page: 55
  year: 2018
  ident: ref_41
  article-title: Anti-inflammatory potential of Lactobacillus plantarum LS/07 in acute colitis in rats
  publication-title: Acta Veterinaria
  doi: 10.2478/acve-2018-0005
  contributor:
    fullname: Chmelarova
– volume: 77
  start-page: 2667
  year: 2022
  ident: ref_84
  article-title: Lactiplantibacillus plantarum attenuates 2,4,6-trinitrobenzenesulfonic acid-induced ulcerative colitis in rats by regulating the inflammatory response, T helper 17 immune response, and intestinal permeability
  publication-title: Biologia
  doi: 10.1007/s11756-022-01111-w
  contributor:
    fullname: Wang
– volume: 62
  start-page: 553
  year: 2015
  ident: ref_40
  article-title: Preventive use of Lactobacillus plantarum LS/07 and inulin to relieve symptoms of acute colitis
  publication-title: Acta Biochim. Pol.
  doi: 10.18388/abp.2015_1008
  contributor:
    fullname: Salaj
– volume: 6
  start-page: 30594
  year: 2016
  ident: ref_29
  article-title: Role of the Gut Microbiome in Modulating Arthritis Progression in Mice
  publication-title: Sci. Rep.
  doi: 10.1038/srep30594
  contributor:
    fullname: Liu
– volume: 2
  start-page: 361
  year: 2015
  ident: ref_38
  article-title: Co-administration of a probiotic strain Lactobacillus plantarum LS/07 CCM7766 with prebiotic inulin alleviates the intestinal inflammation in rats exposed to N,N-dimethylhydrazine
  publication-title: Int. Immunopharmacol.
  contributor:
    fullname: Salaj
– volume: 59
  start-page: 268
  year: 2014
  ident: ref_34
  article-title: Effect of Lactobacillus plantarum LS/07 in combination with flaxseed oil on the microflora, enzymatic activity, and histological changes in the development of chemically induced precancerous growth in the rat colon
  publication-title: Czech J. Anim. Sci.
  doi: 10.17221/7497-CJAS
  contributor:
    fullname: Szabados
– volume: 45
  start-page: 2690
  year: 2008
  ident: ref_57
  article-title: Lactobacillus casei suppresses experimental arthritis by down-regulating T helper 1 effector functions
  publication-title: Mol. Immunol.
  doi: 10.1016/j.molimm.2007.12.010
  contributor:
    fullname: So
– volume: 21
  start-page: 895
  year: 2015
  ident: ref_20
  article-title: The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment
  publication-title: Nat. Med.
  doi: 10.1038/nm.3914
  contributor:
    fullname: Zhang
– volume: 36
  start-page: 2697
  year: 2017
  ident: ref_12
  article-title: The therapeutic effect of probiotics on rheumatoid arthritis: A systematic review and meta-analysis of randomized control trials
  publication-title: Clin. Rheumatol.
  doi: 10.1007/s10067-017-3814-3
  contributor:
    fullname: Mohammed
– volume: 35
  start-page: 1143
  year: 2019
  ident: ref_13
  article-title: Probiotic strategies to prevent necrotizing enterocolitis in preterm infants: A meta-analysis
  publication-title: Pediatr. Surg. Int.
  doi: 10.1007/s00383-019-04547-5
  contributor:
    fullname: Bi
– volume: 40
  start-page: 237
  year: 2008
  ident: ref_74
  article-title: IL-17 induces the production of IL-16 in rheumatoid arthritis
  publication-title: Exp. Mol. Med.
  doi: 10.3858/emm.2008.40.2.237
  contributor:
    fullname: Cho
– volume: 68
  start-page: S75
  year: 2019
  ident: ref_75
  article-title: Study of anti-inflammatory activity of Fatsiphloginum™ (Fatsia japonica) and a new purified triterpene-rich extract of saponins (PS-551) in experimental model of arthritis
  publication-title: Physiol. Res.
  doi: 10.33549/physiolres.934328
  contributor:
    fullname: Tsiklauri
– volume: 69
  start-page: 381
  year: 2010
  ident: ref_51
  article-title: Role of Toll-like receptors in the development of immunotolerance mediated by probiotics
  publication-title: Proc. Nutr. Soc.
  doi: 10.1017/S0029665110001527
  contributor:
    fullname: Gil
– volume: 81
  start-page: 189
  year: 2012
  ident: ref_33
  article-title: The effect of new probiotic strain Lactobacillus plantarum on counts of coliforms, lactobacilli and bacterial enzyme activities in rats exposed to N,N-dimethylhydrazine (chemical carcinogen)
  publication-title: Acta Vet. Brno
  doi: 10.2754/avb201281020189
  contributor:
    fullname: Bomba
– volume: 23
  start-page: 354
  year: 2015
  ident: ref_14
  article-title: Fate, activity, and impact of ingested bacteria within the human gut microbiota
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2015.03.002
  contributor:
    fullname: Derrien
– volume: 11
  start-page: 267
  year: 2004
  ident: ref_65
  article-title: The effects of Enterococcus faecium and selenium on methotrexate treatment in rat adjuvant-induced arthritis
  publication-title: Clin. Dev. Immunol.
  contributor:
    fullname: Matha
– volume: 56
  start-page: kew374
  year: 2016
  ident: ref_59
  article-title: The evidence for microbiome manipulation in inflammatory arthritis
  publication-title: Rheumatology
  doi: 10.1093/rheumatology/kew374
  contributor:
    fullname: Jethwa
– volume: 21
  start-page: 61
  year: 2010
  ident: ref_69
  article-title: The resolution of inflammation and cancer
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2009.11.006
  contributor:
    fullname: Lawrence
– volume: 7
  start-page: 10277
  year: 2017
  ident: ref_17
  article-title: Impact of Immunosuppression on the Metagenomic Composition of the Intestinal Microbiome: A Systems Biology Approach to Post-Transplant Diabetes
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-10471-2
  contributor:
    fullname: Bhat
– volume: 44
  start-page: 2263
  year: 2001
  ident: ref_81
  article-title: Early joint erosions and serum levels of matrix metalloproteinase 1, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 in rheumatoid arthritis
  publication-title: Arthritis Rheumatol.
  doi: 10.1002/1529-0131(200110)44:10<2263::AID-ART389>3.0.CO;2-1
  contributor:
    fullname: Cunnane
– volume: 22
  start-page: 1933
  year: 2007
  ident: ref_66
  article-title: Treatment with Anti-γ-Glutamyl Transpeptidase Antibody Attenuates Osteolysis in Collagen-Induced Arthritis Mice
  publication-title: J. Bone. Miner. Res.
  doi: 10.1359/jbmr.070726
  contributor:
    fullname: Ishizuka
– volume: 9
  start-page: 4969
  year: 2014
  ident: ref_35
  article-title: Preventive effects of probiotic bacteria Lactobacillus plantarum and dietary fiber in chemically-induced mammary carcinogenesis
  publication-title: Anticancer Res.
  contributor:
    fullname: Bobrov
– volume: 30
  start-page: 430
  year: 2014
  ident: ref_25
  article-title: Probiotic supplementation improves inflammatory status in patients with rheumatoid arthritis
  publication-title: Nutrition
  doi: 10.1016/j.nut.2013.09.007
  contributor:
    fullname: Alipour
– volume: 6
  start-page: 2719
  year: 2016
  ident: ref_36
  article-title: Anticancer and Immunomodulatory Effects of Lactobacillus plantarum LS/07, Inulin and Melatonin in NMU-induced Rat Model of Breast Cancer
  publication-title: Anticancer Res.
  contributor:
    fullname: Bobrov
– volume: 10
  start-page: 11
  year: 2018
  ident: ref_47
  article-title: Probiotics and the Gut Immune System: Indirect Regulation
  publication-title: Probiotics Antimicrob. Proteins
  doi: 10.1007/s12602-017-9322-6
  contributor:
    fullname: Weber
– volume: 19
  start-page: 869
  year: 2016
  ident: ref_27
  article-title: Clinical and metabolic response to probiotic supplementation in patients with rheumatoid arthritis: A randomized, double-blind, placebo-controlled trial
  publication-title: Int. J. Rheum. Dis.
  doi: 10.1111/1756-185X.12888
  contributor:
    fullname: Zamani
– volume: 44
  start-page: 2176
  year: 2001
  ident: ref_73
  article-title: Interleukin-17 enhances tumor necrosis factor alpha-induced synthesis of interleukins 1,6, and 8 in skin and synovial fibroblasts: A possible role as a “fine-tuning cytokine” in inflammation processes
  publication-title: Arthritis Rheumatol.
  doi: 10.1002/1529-0131(200109)44:9<2176::AID-ART371>3.0.CO;2-4
  contributor:
    fullname: Katz
– volume: 2018
  start-page: 1
  year: 2018
  ident: ref_52
  article-title: Immunomodulatory Effects of Probiotics on Cytokine Profiles
  publication-title: Biomed. Res. Int.
  contributor:
    fullname: Azad
– volume: 32
  start-page: 3517
  year: 2012
  ident: ref_67
  article-title: Effect of methotrexate on inflammatory cells redistribution in experimental adjuvant arthritis
  publication-title: Rheumatol. Int.
  doi: 10.1007/s00296-011-2177-3
  contributor:
    fullname: Janega
– volume: 92
  start-page: 1
  year: 1993
  ident: ref_2
  article-title: Rheumatoid arthritis: How well do the theories fit the evidence?
  publication-title: Clin. Exp. Immunol.
  doi: 10.1111/j.1365-2249.1993.tb05938.x
  contributor:
    fullname: McCulloch
– volume: 26
  start-page: 67
  year: 2018
  ident: ref_61
  article-title: The efficacy of probiotic supplementation in rheumatoid arthritis: A meta-analysis of randomized, controlled trials
  publication-title: Inflammopharmacology
  doi: 10.1007/s10787-017-0436-y
  contributor:
    fullname: Rudbane
– volume: 8
  start-page: 43
  year: 2016
  ident: ref_21
  article-title: An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis
  publication-title: Genome Med.
  doi: 10.1186/s13073-016-0299-7
  contributor:
    fullname: Chen
– volume: 7
  start-page: 107
  year: 2019
  ident: ref_45
  article-title: A single bacterium restores the microbiome dysbiosis to protect bones from destruction in a rat model of rheumatoid arthritis
  publication-title: Microbiome
  doi: 10.1186/s40168-019-0719-1
  contributor:
    fullname: Pan
– volume: 11
  start-page: 506
  year: 2014
  ident: ref_5
  article-title: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/nrgastro.2014.66
  contributor:
    fullname: Hill
– volume: 6
  start-page: 612
  year: 2015
  ident: ref_54
  article-title: Nutritional Keys for Intestinal Barrier Modulation
  publication-title: Front. Immunol.
  contributor:
    fullname: Cavalcanti
– volume: 3
  start-page: 118
  year: 2001
  ident: ref_79
  article-title: Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8
  publication-title: Arthritis Res.
  doi: 10.1186/ar149
  contributor:
    fullname: Hayashida
– volume: 33
  start-page: 1
  year: 2013
  ident: ref_62
  article-title: Lactobacillus casei and Lactobacillus acidophilus Regulate Inflammatory Pathway and Improve Antioxidant Status in Collagen-Induced Arthritic Rats
  publication-title: J. Interferon. Cytokine. Res.
  doi: 10.1089/jir.2012.0034
  contributor:
    fullname: Amdekar
– volume: 10
  start-page: 2235
  year: 2016
  ident: ref_7
  article-title: Ecological robustness of the gut microbiota in response to ingestion of transient food-borne microbes
  publication-title: ISME J.
  doi: 10.1038/ismej.2016.13
  contributor:
    fullname: Zhang
– volume: 12
  start-page: 398
  year: 2016
  ident: ref_42
  article-title: How the microbiota shapes rheumatic diseases
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2016.85
  contributor:
    fullname: Marzorati
– volume: 17
  start-page: 519
  year: 2014
  ident: ref_24
  article-title: Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid arthritis patients: A randomized double-blind clinical trial
  publication-title: Int. J. Rheum. Dis.
  doi: 10.1111/1756-185X.12333
  contributor:
    fullname: Alipour
– volume: 5
  start-page: 461
  year: 2014
  ident: ref_50
  article-title: Toll-Like Receptor Signaling Pathways
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2014.00461
  contributor:
    fullname: Kawasaki
– volume: 12
  start-page: 14
  year: 2016
  ident: ref_72
  article-title: Interleukin-1 function and role in rheumatic disease
  publication-title: Nat. Rev. Rheumatol.
  doi: 10.1038/nrrheum.2016.166
  contributor:
    fullname: Schett
– volume: 2015
  start-page: 505878
  year: 2015
  ident: ref_19
  article-title: The role of probiotic lactic acid bacteria and bifidobacteria in the prevention and treatment of inflammatory bowel disease and other related diseases: A systematic review of randomized human clinical trials
  publication-title: Biomed. Res. Int.
  contributor:
    fullname: Gil
– volume: 40
  start-page: 193
  year: 2018
  ident: ref_85
  article-title: Experimental Animal Models for Rheumatoid Arthritis
  publication-title: Immunopharmacol. Immunotoxicol.
  doi: 10.1080/08923973.2018.1434793
  contributor:
    fullname: Choudhary
– volume: 56
  start-page: 99
  year: 2011
  ident: ref_32
  article-title: Effects of a probiotic in combination with prebiotics on intestinal lactobacilli and coliforms and activities of bacterial enzymes in 1,2-dimethylhydrazine exposed rats
  publication-title: Czech J. Anim. Sci.
  doi: 10.17221/56/2010-CJAS
  contributor:
    fullname: Bomba
– volume: 2013
  start-page: 135142
  year: 2013
  ident: ref_37
  article-title: The effects of two Lactobacillus plantarum strains on rat lipid metabolism receiving a high fat diet
  publication-title: Sci. World J.
  doi: 10.1155/2013/135142
  contributor:
    fullname: Salaj
– volume: 26
  start-page: 101
  year: 2014
  ident: ref_4
  article-title: Microbiome and mucosal inflammation as extra-articular triggers for rheumatoid arthritis and autoimmunity
  publication-title: Curr. Opin. Rheumatol.
  doi: 10.1097/BOR.0000000000000008
  contributor:
    fullname: Brusca
– volume: 24
  start-page: 189
  year: 2016
  ident: ref_43
  article-title: Probiotic bacteria: A viable adjuvant therapy for relieving symptoms of rheumatoid arthritis
  publication-title: Inflammopharmacology
  doi: 10.1007/s10787-016-0277-0
  contributor:
    fullname: Wang
– volume: 27
  start-page: 519
  year: 2009
  ident: ref_70
  article-title: Immunological and Inflammatory Functions of the Interleukin-1 Family
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev.immunol.021908.132612
  contributor:
    fullname: Dinarello
– volume: 90
  start-page: 772
  year: 1992
  ident: ref_78
  article-title: Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritis
  publication-title: J. Clin. Investig.
  doi: 10.1172/JCI115950
  contributor:
    fullname: Koch
– volume: 66
  start-page: 250
  year: 2014
  ident: ref_28
  article-title: Partial depletion of natural gut flora by antibiotic aggravates collagen induced arthritis (CIA) in mice
  publication-title: Pharmacol. Rep.
  doi: 10.1016/j.pharep.2013.09.007
  contributor:
    fullname: Szczepanik
– volume: 44
  start-page: 1
  year: 2014
  ident: ref_9
  article-title: Probiotics, gut microbiota and health
  publication-title: Med. Mal. Infect.
  doi: 10.1016/j.medmal.2013.10.002
  contributor:
    fullname: Butel
– volume: 67
  start-page: 170
  year: 2013
  ident: ref_23
  article-title: Analysis of Fecal Lactobacillus Community Structure in Patients with Early Rheumatoid Arthritis
  publication-title: Curr. Microbiol.
  doi: 10.1007/s00284-013-0338-1
  contributor:
    fullname: Liu
– volume: 2
  start-page: 473
  year: 2003
  ident: ref_56
  article-title: Therapeutic strategies for rheumatoid arthritis
  publication-title: Nat. Rev. Drug. Discov.
  doi: 10.1038/nrd1109
  contributor:
    fullname: Smolen
– volume: 12
  start-page: 578386
  year: 2021
  ident: ref_48
  article-title: Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2021.578386
  contributor:
    fullname: Cristofori
– volume: 36
  start-page: 471
  year: 2017
  ident: ref_82
  article-title: Evaluation of liposomal carnosine in adjuvant arthritis
  publication-title: Gen. Physiol. Biophys.
  doi: 10.4149/gpb_2017014
  contributor:
    fullname: Fedorova
– volume: 57
  start-page: 422
  year: 2010
  ident: ref_31
  article-title: The effect of probiotic microorganisms and bioactive compounds on chemically induced carcinogenesis in rats
  publication-title: Neoplasma
  doi: 10.4149/neo_2010_05_422
  contributor:
    fullname: Chmelarova
– volume: 32
  start-page: 211
  year: 2003
  ident: ref_26
  article-title: Effects of probiotic therapy on the activity and activation of mild rheumatoid arthritis—A pilot study
  publication-title: Scand J. Rheumatol.
  doi: 10.1080/03009740310003695
  contributor:
    fullname: Hatakka
– ident: ref_68
  doi: 10.3390/nu13041268
– volume: 12
  start-page: 711788
  year: 2021
  ident: ref_10
  article-title: Probiotic Supplementation for Rheumatoid Arthritis: A Promising Adjuvant Therapy in the Gut Microbiome Era
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2021.711788
  contributor:
    fullname: Ferro
– volume: 2015
  start-page: 1
  year: 2015
  ident: ref_30
  article-title: Lactobacillus acidophilus Suppresses Colitis-Associated Activation of the IL-23/Th17 Axis
  publication-title: J. Immunol. Res.
  doi: 10.1155/2015/206731
  contributor:
    fullname: Chen
– ident: ref_60
  doi: 10.3390/ijms22062805
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Snippet The gut microbiome (GM) of rheumatic arthritis (RA) patients is often altered in composition and function. Moreover, methotrexate (MTX), one of the most...
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StartPage 297
SubjectTerms adjuvant arthritis
Animals
Arthritis
Bacteria
Biometrics
Chemical compounds
Composition
Cytokines
Disease
Etiology
Experiments
Gelatinase B
Immune system
Immunosuppressive agents
Inflammation
Inflammatory bowel disease
Intestinal microflora
Joint diseases
Lactiplantibacillus plantarum LS/07
Lactobacilli
Methotrexate
Microbiomes
Microbiota
Monocyte chemoattractant protein 1
Pharmaceuticals
Probiotics
γ-Glutamyltransferase
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Title Enhanced Anti-Inflammatory Effect of the Combination of Lactiplantibacillus plantarum LS/07 with Methotrexate Compared to Their Monotherapies Studied in Experimental Arthritis
URI https://www.ncbi.nlm.nih.gov/pubmed/36615489
https://www.proquest.com/docview/2761196990
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https://pubmed.ncbi.nlm.nih.gov/PMC9822002
https://doaj.org/article/7e61c86a08e2463688b67ee9b6c2e3a1
Volume 28
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