Investigation of the Anti-Leishmania (Leishmania) infantum Activity of Some Natural Sesquiterpene Lactones

• Published in: Molecules (Basel, Switzerland) Vol. 22; no. 5; p. 685
• Main Authors: Wulsten, Imke, Costa-Silva, Thais, Mesquita, Juliana, Lima, Marta, Galuppo, Mariana, Taniwaki, Noemi, Borborema, Samanta, Da Costa, Fernando, Schmidt, Thomas, Tempone, Andre
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.04.2017; MDPI
• Subjects: Animals; Antiprotozoal Agents - pharmacology; Bridged-Ring Compounds - pharmacology; Cells, Cultured; Drug Evaluation, Preclinical; drugs; Furans - pharmacology; helenalin acetate; Inhibitory Concentration 50; Lactones - pharmacology; Leishmania (L.) infantum; Leishmania infantum - drug effects; Leishmania infantum - ultrastructure; Leishmaniasis, Visceral - drug therapy; Macrophages, Peritoneal - drug effects; mexicanin I; Mice, Inbred BALB C; nitric oxide; Nitric Oxide - metabolism; Permeability; pseudoguaianolides; Reactive oxygen species; sesquiterpene lactones; Sesquiterpenes - pharmacology; Sesquiterpenes, Germacrane - pharmacology; mexicanin I; nitric oxide; Leishmania (L.) infantum; drugs; sesquiterpene lactones; pseudoguaianolides; helenalin acetate

Leishmaniases are neglected infectious diseases caused by parasites of the ‘protozoan’ genus Leishmania. Depending on the parasite species, different clinical forms are known as cutaneous, muco-cutaneous, and the visceral leishmaniasis (VL). VL is particularly fatal and the therapy presents limitati...