A dose-ranging study of the physiological and self-reported effects of repeated, rapid infusion of remifentanil in people with opioid use disorder and physical dependence on fentanyl

• Published in: Psychopharmacology Vol. 241; no. 6; pp. 1227 - 1236
• Main Authors: Lile, Joshua A., Shellenberg, Thomas P., Babalonis, Shanna, Hatton, Kevin W., Hays, Lon R., Rayapati, Abner O., Stoops, William W., Wesley, Michael J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2024; Springer; Springer Nature B.V
• Subjects: Adult; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - pharmacokinetics; Biomedical and Life Sciences; Biomedicine; Blindness; Blood pressure; Blood Pressure - drug effects; Carbon dioxide; Decision making; Dosage; Dosage and administration; Dose-Response Relationship, Drug; Drug abuse; Drug addiction; Drug dependence; Drug dosages; Female; Fentanyl; Fentanyl - administration & dosage; Fentanyl - pharmacokinetics; Heart rate; Heart Rate - drug effects; Humans; Infusions, Intravenous; Male; Middle Aged; Narcotics; Neurosciences; Opioid-Related Disorders - drug therapy; Opioids; Original Investigation; Oxycodone; Oxycodone - administration & dosage; Oxycodone - pharmacokinetics; Pharmacokinetics; Pharmacology/Toxicology; Physiological aspects; Physiology; Piperidines - administration & dosage; Piperidines - pharmacokinetics; Piperidines - pharmacology; Psychiatry; Remifentanil; Remifentanil - administration & dosage; Remifentanil - pharmacology; Self Report; Single-Blind Method; Statistical analysis; Substance use disorder; Young Adult; United States; Street value questionnaire; Addiction; Capnography; Intravenous; Subjective effects; Pupillometry; Individualized dosing; Fentanyl; Tolerance

Rationale Understanding mechanisms of drug use decisions will inform the development of treatments for opioid use disorder (OUD). Decision-making experiments using neurobehavioral approaches require many trials or events of interest for statistical analysis, but the pharmacokinetics of most opioids...