Inhibition of Glutamate Release from Rat Cortical Nerve Terminals by Dehydrocorydaline, an Alkaloid from Corydalis yanhusuo

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 3; p. 960
• Main Authors: Lin, Tzu-Yu, Chen, I-Yen, Lee, Ming-Yi, Lu, Cheng-Wei, Chiu, Kuan-Ming, Wang, Su-Jane
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.01.2022; MDPI
• Subjects: Alkaloids - pharmacology; Alzheimer's disease; Animals; Ca2+ influx; Calcium - metabolism; Calcium Channel Blockers - pharmacology; Calcium Channels - chemistry; Cardiovascular disease; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Corydalis - chemistry; dehydrocorydaline; glutamate release; Glutamic Acid - metabolism; Kinases; Male; MAPK/ERK/synapsin I; Nerve Tissue - drug effects; Nerve Tissue - metabolism; neuroprotection; Neuroprotective Agents - pharmacology; Proteins; Rats; Rats, Sprague-Dawley; synaptosomes; dehydrocorydaline; Ca2+ influx; neuroprotection; synaptosomes; glutamate release; MAPK/ERK/synapsin I

Excessive release of glutamate induces excitotoxicity and causes neuronal damage in several neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for preventing and treating neurological disorders. Dehydrocorydaline (DHC), an active alkaloid compound isolated...