Cell type-specific histone acetylation profiling of Alzheimer’s disease subjects and integration with genetics

• Published in: Frontiers in molecular neuroscience Vol. 15; p. 948456
• Main Authors: Ramamurthy, Easwaran, Welch, Gwyneth, Cheng, Jemmie, Yuan, Yixin, Gunsalus, Laura, Bennett, David A., Tsai, Li-Huei, Pfenning, Andreas R.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 06.01.2023; Frontiers Media S.A
• Subjects: Acetylation; Age; Alzheimer's disease; Biomarkers; Brain; brain cell types; Consortia; Epigenomics; Gene regulation; Genes; Genetic diversity; genetics; Genomes; genomics; Health risk assessment; Histones; Microglia; Mutation; Neurodegenerative diseases; Neuroscience; Prefrontal cortex; Proteins; Regulatory sequences; Secretase; Single-nucleotide polymorphism; β-Amyloid; β-Site APP-cleaving enzyme 1; genomics; Epigenomics; genetics; Alzheimer’s disease; brain cell types

We profile genome-wide histone 3 lysine 27 acetylation (H3K27ac) of 3 major brain cell types from hippocampus and dorsolateral prefrontal cortex (dlPFC) of subjects with and without Alzheimer’s Disease (AD). We confirm that single nucleotide polymorphisms (SNPs) associated with late onset AD (LOAD)...