Chronic Sensing of Subthalamic Local Field Potentials: Comparison of First and Second Generation Implantable Bidirectional Systems Within a Single Subject

• Published in: Frontiers in neuroscience Vol. 15; p. 725797
• Main Authors: Cummins, Daniel D., Kochanski, Ryan B., Gilron, Roee, Swann, Nicole C., Little, Simon, Hammer, Lauren H., Starr, Philip A.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 10.08.2021; Frontiers Media S.A
• Subjects: beta oscillations; bidirectional neural interface; Deep brain stimulation; Design specifications; Electrophysiological recording; local field potential; Magnetic resonance imaging; Movement disorders; Neurodegenerative diseases; Neuroscience; Parkinson's disease; Software; Solitary tract nucleus; subthalamic nucleus; Time series; bidirectional neural interface; local field potential; subthalamic nucleus; deep brain stimulation; beta oscillations
• DOI: 10.3389/fnins.2021.725797
• ISSN: 1662-453X; 1662-4548

Many adaptative deep brain stimulation (DBS) paradigms rely upon the ability to sense neural signatures of specific clinical signs or symptoms in order to modulate therapeutic stimulation. In first-generation bidirectional neurostimulators, the ability to sense neural signals during active stimulation was often limited by artifact. Newer devices, with improved design specifications for sensing, have recently been developed and are now clinically available. To compare the sensing capabilities of the first-generation Medtronic PC + S and second-generation Percept PC neurostimulators within a single patient. A 42-year-old man with Parkinson's disease was initially implanted with left STN DBS leads connected to a PC + S implantable pulse generator. Four years later, the PC + S was replaced with the Percept PC. Local field potential (LFP) signals were recorded, both with stimulation OFF and ON, at multiple timepoints with each device and compared. Offline processing of time series data included artifact removal using digital filtering and template subtraction, before subsequent spectral analysis. With Percept PC, embedded processing of spectral power within a narrow frequency band was also utilized. In the absence of stimulation, both devices demonstrated a peak in the beta range (approximately 20 Hz), which was stable throughout the 4-year period. Similar to previous reports, recordings with the PC + S during active stimulation demonstrated significant stimulation artifact, limiting the ability to recover meaningful LFP signal. In contrast, the Percept PC, using the same electrodes and stimulation settings, produced time series data during stimulation with spectral analysis revealing a peak in the beta-band. Online analysis by the Percept demonstrated a reduction in beta-band activity with increasing stimulation amplitude. This report highlights recent advances in implantable neurostimulator technology for DBS, demonstrating improvements in sensing capabilities during active stimulation between first- and second-generation devices. The ability to reliably sense during stimulation is an important step toward both the clinical implementation of adaptive algorithms and the further investigation into the neurophysiology underlying movement disorders.