A New Oleanane Type Saponin from the Aerial Parts of Nigella sativa with Anti-Oxidant and Anti-Diabetic Potential

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 9; p. 2171
• Main Authors: Parveen, Amna, Farooq, Muhammad Asim, Kyunn, Whang Wan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.05.2020; MDPI
• Subjects: Antidiabetics; Antifungal agents; antioxidant; Antioxidants - analysis; Antioxidants - chemistry; Antioxidants - isolation & purification; Antioxidants - pharmacology; Benzothiazoles - chemistry; Biphenyl Compounds - chemistry; characterization; Chromatography; Chromatography, High Pressure Liquid; column chromatography; Diabetes; Diabetes Mellitus - drug therapy; Flavonoids - analysis; Flavonoids - isolation & purification; Flavonoids - pharmacology; Glycoside Hydrolase Inhibitors - pharmacology; Hypertension; Inhibitory Concentration 50; isolation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Nigella sativa; Nigella sativa - chemistry; Nigella sativa - enzymology; Oleanolic Acid - analogs & derivatives; Oleanolic Acid - analysis; Oleanolic Acid - chemistry; Oleanolic Acid - isolation & purification; Oleanolic Acid - pharmacology; Phytochemicals; Picrates - chemistry; Plant Components, Aerial - chemistry; Plant Components, Aerial - enzymology; Plant Extracts - analysis; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Protein Tyrosine Phosphatases - antagonists & inhibitors; Saponins - analysis; Saponins - chemistry; Saponins - isolation & purification; Saponins - pharmacology; Seeds; Spectrum analysis; Sulfonic Acids - chemistry; Triterpenes - analysis; Triterpenes - isolation & purification; Triterpenes - pharmacology; triterpenoid saponin derivatives; antioxidant; Nigella sativa; triterpenoid saponin derivatives; isolation; column chromatography; flavonoids; characterization

Natural product studies explore potential and interesting new compounds to discover innovative drugs. Nigella sativa (N. sativa) (Ranunculaceae) is traditionally used to treat diabetes. Flavonoids and triterpenoid mostly show anti-diabetic activity. The current study aim to identify new compounds by...