Improving Pediatric Protein Binding Estimates: An Evaluation of α1-Acid Glycoprotein Maturation in Healthy and Infected Subjects

• Published in: Clinical pharmacokinetics Vol. 57; no. 5; pp. 577 - 589
• Main Authors: Maharaj, Anil R., Gonzalez, Daniel, Cohen-Wolkowiez, Michael, Hornik, Christoph P., Edginton, Andrea N.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.05.2018; Springer Nature B.V
• Subjects: Acids; Adolescent; Adults; Age; Bacterial infections; Bacterial Infections - metabolism; Binding sites; Child; Child, Preschool; Crohn's disease; Health care; Heart attacks; Humans; Infant; Infant, Newborn; Infections; Internal Medicine; Ligands; Medicine; Medicine & Public Health; Models, Biological; Original Research Article; Orosomucoid - metabolism; Pediatrics; Pharmacology/Toxicology; Pharmacotherapy; Plasma; Protein Binding; Proteins

Background Differences in plasma protein levels observed between children and adults can alter the extent of xenobiotic binding in plasma, resulting in divergent patterns of exposure. Objective This study aims to quantify the ontogeny of α1-acid glycoprotein in both healthy and infected subjects. Me...