Knockdown of ribonuclease inhibitor expression with siRNA in non-invasive bladder cancer cell line BIU-87 promotes growth and metastasis potentials

• Published in: Molecular and cellular biochemistry Vol. 349; no. 1-2; pp. 83 - 95
• Main Authors: Chen, Junxia, Ou-Yang, Xi, Gao, Juan, Zhu, Jun, He, Xiaoyan, Rong, Jiang
• Format: Journal Article
• Language: English
• Published: Boston Boston : Springer US 01.03.2011; Springer US; Springer; Springer Nature B.V
• Subjects: Animals; Biochemistry; Biomedical and Life Sciences; Bladder; Bladder cancer; Bladder cancer cells; Cadherins - metabolism; Cardiology; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Movement - genetics; Cell Proliferation; Cell Shape; Cellular biology; Collagenases - metabolism; Gene Knockdown Techniques; Genetic vectors; Growth; Health aspects; Humans; Life Sciences; Medical Biochemistry; Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness - genetics; Neoplasm Metastasis; Neoplasm Transplantation; Neovascularization, Pathologic - genetics; NM23 Nucleoside Diphosphate Kinases - metabolism; Oncology; Ribonuclease; Ribonuclease inhibitor; Ribonucleases; RNA; RNA Interference; RNA, Small Interfering - genetics; Rodents; small interfering RNA; Transplantation, Heterologous; Tumor Burden; Tumor growth; Tumors; Urinary Bladder Neoplasms - blood supply; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - pathology; Ribonuclease inhibitor; Small interfering RNA; Bladder cancer cells; Metastasis; Tumor growth

Human ribonuclease inhibitor (RI) is a cytoplasmic acidic protein. RI is constructed almost entirely of leucine-rich repeats, which might be involved in some unknown biological functions like other structurally similar proteins besides inhibiting RNase A and angiogenin activities. Our previous exper...