Aberrant Functional Connectivity of Sensorimotor Network and Its Relationship With Executive Dysfunction in Bipolar Disorder Type I

• Published in: Frontiers in neuroscience Vol. 15; p. 823550
• Main Authors: Zhu, Wenjing, Tang, Wenxin, Liang, Yan, Jiang, Xiaoying, Li, Yi, Chen, Zhiyu, Zhu, Cheng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 21.02.2022; Frontiers Media S.A
• Subjects: Affective disorders; Bipolar disorder; Brain research; Data processing; Executive function; functional connectivity; Functional magnetic resonance imaging; Hospitals; Illnesses; Mental depression; Neuroscience; Patients; Postcentral gyrus; resting-state fMRI; sensorimotor network; Sensorimotor system; bipolar disorder; functional connectivity; sensorimotor network; resting-state fMRI; executive function
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2021.823550

The key pathophysiological mechanism of executive dysfunction in patients with bipolar disorder type I (BD-I) is still unclear. Previous studies have demonstrated that it may be related to the disbalance of the sensory motor network (SMN). This study was designed to explore the aberrant functional connectivity (FC) of SMN in BD-I patients and its potential associations with executive dysfunction. Eighteen BD-I patients and 20 healthy controls (HCs) underwent resting-state fMRI scans. The intranetwork and internetwork functional connectivities of SMN were extracted by independent component analysis (ICA). Clinical symptoms were assessed by the Bech-Rafaelsen Mania Rating Scale (BRMS) and Positive and Negative Syndrome Scale (PANSS). Executive function was measured by digit span tasks and a verbal fluency test. Finally, linear regression and correlation analyses were applied to measure the potential associations between clinical symptoms, intranetwork and internetwork functional connectivities, and executive function performance. (1) Patients with BD-I showed increased connectivity in the right paracentral lobule and the right postcentral gyrus within the SMN, and the increased connectivity value was positively correlated with the BRMS score ( < 0.05) but negatively correlated with digit span forward scores ( < 0.05). (2) Compared with HC, the connectivity value increased between the SMN and dorsal attention network (DAN) ( < 0.01) and between the default mode network (DMN) and DAN ( < 0.05) but decreased between the DAN and auditory network (AN) ( < 0.05) and between the SMN and DMN ( < 0.01) in patients with BD-I. (3) Digit span forward scores and education of all participants were negatively correlated with FC between SMN and DAN. Age of all subjects was positively correlated with FC between SMN and DMN. Our findings suggest that the sensorimotor network of BD-I has abnormal functional connections within and between networks, and the abnormal FC value correlated with clinical symptoms and executive function, which provide new information for exploring the neural physiopathology of executive dysfunction in BD-I patients.