NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface

A trans-agency workshop on the blood-brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the Combat Casualty Care Research Program at the Department of Defense, was conducted in Bethesda MD on June 7-8, 2016. The workshop was structured...

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Published inFluids and barriers of the CNS Vol. 14; no. 1; p. 12
Main Authors Ochocinska, Margaret J, Zlokovic, Berislav V, Searson, Peter C, Crowder, A Tamara, Kraig, Richard P, Ljubimova, Julia Y, Mainprize, Todd G, Banks, William A, Warren, Ronald Q, Kindzelski, Andrei, Timmer, William, Liu, Christina H
Format Journal Article
LanguageEnglish
Published England BioMed Central 01.05.2017
BMC
Subjects
Animals
Biological Transport
Biomarkers
Blood-brain barrier
Blood-Brain Barrier - diagnostic imaging
Blood-Brain Barrier - pathology
Blood-Brain Barrier - physiopathology
Brain cancer
Brain Diseases - diagnostic imaging
Brain Diseases - pathology
Brain Diseases - physiopathology
Brain injury
Brain research
Cancer
Central nervous system
Deoxyribonucleic acid
DNA
Drug delivery
Exosomes
Extracellular vesicles
Humans
Immune system
Lymphoma
Magnetic Resonance Imaging
Medical prognosis
Nanoparticles
National Institutes of Health (U.S.)
Neurodegeneration
Patients
Review
Thrombosis
Translation
Translational Medical Research
Traumatic brain injury
Tumors
Ultrasonic imaging
United States
Traumatic brain injury
Neurodegeneration
Therapeutics
Extracellular vesicles
Delivery
Exosomes
Blood–brain barrier
Cancer
Online AccessGet full text

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Abstract A trans-agency workshop on the blood-brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the Combat Casualty Care Research Program at the Department of Defense, was conducted in Bethesda MD on June 7-8, 2016. The workshop was structured into four sessions: (1) blood sciences; (2) exosome therapeutics; (3) next generation in vitro blood-brain barrier (BBB) models; and (4) BBB delivery and targeting. The first day of the workshop focused on the physiology of the blood and neuro-vascular unit, blood or biofluid-based molecular markers, extracellular vesicles associated with brain injury, and how these entities can be employed to better evaluate injury states and/or deliver therapeutics. The second day of the workshop focused on technical advances in in vitro models, BBB manipulations and nanoparticle-based drug carrier designs, with the goal of improving drug delivery to the central nervous system. The presentations and discussions underscored the role of the BBI in brain injury, as well as the role of the BBB as both a limiting factor and a potential conduit for drug delivery to the brain. At the conclusion of the meeting, the participants discussed challenges and opportunities confronting BBI translational researchers. In particular, the participants recommended using BBI translational research to stimulate advances in diagnostics, as well as targeted delivery approaches for detection and therapy of both brain injury and disease.
AbstractList A trans-agency workshop on the blood-brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the Combat Casualty Care Research Program at the Department of Defense, was conducted in Bethesda MD on June 7-8, 2016. The workshop was structured into four sessions: (1) blood sciences; (2) exosome therapeutics; (3) next generation in vitro blood-brain barrier (BBB) models; and (4) BBB delivery and targeting. The first day of the workshop focused on the physiology of the blood and neuro-vascular unit, blood or biofluid-based molecular markers, extracellular vesicles associated with brain injury, and how these entities can be employed to better evaluate injury states and/or deliver therapeutics. The second day of the workshop focused on technical advances in in vitro models, BBB manipulations and nanoparticle-based drug carrier designs, with the goal of improving drug delivery to the central nervous system. The presentations and discussions underscored the role of the BBI in brain injury, as well as the role of the BBB as both a limiting factor and a potential conduit for drug delivery to the brain. At the conclusion of the meeting, the participants discussed challenges and opportunities confronting BBI translational researchers. In particular, the participants recommended using BBI translational research to stimulate advances in diagnostics, as well as targeted delivery approaches for detection and therapy of both brain injury and disease.
Abstract A trans-agency workshop on the blood–brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the Combat Casualty Care Research Program at the Department of Defense, was conducted in Bethesda MD on June 7–8, 2016. The workshop was structured into four sessions: (1) blood sciences; (2) exosome therapeutics; (3) next generation in vitro blood–brain barrier (BBB) models; and (4) BBB delivery and targeting. The first day of the workshop focused on the physiology of the blood and neuro-vascular unit, blood or biofluid-based molecular markers, extracellular vesicles associated with brain injury, and how these entities can be employed to better evaluate injury states and/or deliver therapeutics. The second day of the workshop focused on technical advances in in vitro models, BBB manipulations and nanoparticle-based drug carrier designs, with the goal of improving drug delivery to the central nervous system. The presentations and discussions underscored the role of the BBI in brain injury, as well as the role of the BBB as both a limiting factor and a potential conduit for drug delivery to the brain. At the conclusion of the meeting, the participants discussed challenges and opportunities confronting BBI translational researchers. In particular, the participants recommended using BBI translational research to stimulate advances in diagnostics, as well as targeted delivery approaches for detection and therapy of both brain injury and disease.
ArticleNumber 12
Author Kindzelski, Andrei
Ochocinska, Margaret J
Searson, Peter C
Ljubimova, Julia Y
Timmer, William
Crowder, A Tamara
Kraig, Richard P
Liu, Christina H
Zlokovic, Berislav V
Warren, Ronald Q
Banks, William A
Mainprize, Todd G
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– sequence: 2
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  surname: Crowder
  fullname: Crowder, A Tamara
  organization: Combat Casualty Care Research Program, Fort Detrick, MD, USA
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  organization: University of Washington, Seattle, WA, USA
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  organization: National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
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  organization: National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
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  givenname: Christina H
  surname: Liu
  fullname: Liu, Christina H
  organization: National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28457227$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords Traumatic brain injury
Neurodegeneration
Therapeutics
Extracellular vesicles
Delivery
Exosomes
Blood–brain barrier
Cancer
Language English
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Snippet A trans-agency workshop on the blood-brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the...
A trans-agency workshop on the blood–brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute and the...
Abstract A trans-agency workshop on the blood–brain interface (BBI), sponsored by the National Heart, Lung and Blood Institute, the National Cancer Institute...
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SubjectTerms Animals
Biological Transport
Biomarkers
Blood-brain barrier
Blood-Brain Barrier - diagnostic imaging
Blood-Brain Barrier - pathology
Blood-Brain Barrier - physiopathology
Brain cancer
Brain Diseases - diagnostic imaging
Brain Diseases - pathology
Brain Diseases - physiopathology
Brain injury
Brain research
Cancer
Central nervous system
Deoxyribonucleic acid
DNA
Drug delivery
Exosomes
Extracellular vesicles
Humans
Immune system
Lymphoma
Magnetic Resonance Imaging
Medical prognosis
Nanoparticles
National Institutes of Health (U.S.)
Neurodegeneration
Patients
Review
Thrombosis
Translation
Translational Medical Research
Traumatic brain injury
Tumors
Ultrasonic imaging
United States
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Title NIH workshop report on the trans-agency blood-brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface
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