Raman Multi-Omic Snapshot and Statistical Validation of Structural Differences between Herpes Simplex Type I and Epstein–Barr Viruses

• Published in: International journal of molecular sciences Vol. 24; no. 21; p. 15567
• Main Authors: Pezzotti, Giuseppe, Ohgitani, Eriko, Imamura, Hayata, Ikegami, Saki, Shin-Ya, Masaharu, Adachi, Tetsuya, Adachi, Keiji, Yamamoto, Toshiro, Kanamura, Narisato, Marin, Elia, Zhu, Wenliang, Higasa, Koichiro, Yasukochi, Yoshiki, Okuma, Kazu, Mazda, Osam
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.10.2023
• Subjects: Amino acids; Carbohydrates; Comparative analysis; Correspondence; Epstein-Barr virus; Epstein-Barr Virus Infections; Genomes; Glycoproteins; Herpes Simplex; Herpes viruses; Herpesvirus 1, Human; Herpesvirus 4, Human; Humans; Lymphoma; Machine learning; Multiomics; Proteins; Raman spectroscopy; Spectrum analysis; Tryptophan; Virology; Japan; herpes simplex virus type I; glycoproteins; secondary protein structure; Raman spectroscopy; surface pH; Epstein–Barr virus

Raman spectroscopy was applied to study the structural differences between herpes simplex virus Type I (HSV-1) and Epstein–Barr virus (EBV). Raman spectra were first collected with statistical validity on clusters of the respective virions and analyzed according to principal component analysis (PCA)...