Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors - Salomatina, Oksana; Popadyuk, Irina; Zakharenko, Alexandra; Zakharova, Olga; Fadeev, Dmitriy; Komarova, Nina; Reynisson, Jóhannes; Arabshahi, H.; Chand, Raina; Volcho, Konstantin; Salakhutdinov, Nariman; Lavrik, Olga (Molecules (Basel, Switzerland), 2018)
Keywords: amide; Bile; Bile Acids and Salts - chemical synthesis; Bile Acids and Salts - chemistry; Bile Acids and Salts - pharmacology; Binding Sites; cancer; chenodeoxycholic acid; deoxycholic acid; Deoxyribonucleic acid; DNA; DNA repair; Drug Evaluation, Preclinical; Enzymes; HCT116 Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; molecular modelling; Niacinamide - analogs & derivatives; Niacinamide - chemical synthesis; Niacinamide - chemistry; Niacinamide - pharmacology; Phosphodiesterase Inhibitors - chemical synthesis; Phosphodiesterase Inhibitors - chemistry; Phosphodiesterase Inhibitors - pharmacology; Phosphoric Diester Hydrolases - metabolism; Tdp1 inhibitor; Tryptamines - chemical synthesis; Tryptamines - chemistry; Tryptamines - pharmacology; tumor; ursodeoxycholic acid; virtual screening; Tdp1 inhibitor; amide; ursodeoxycholic acid; virtual screening; molecular modelling; tumor; cancer; deoxycholic acid; chenodeoxycholic acid